The present invention relates to
lipopeptide-based compounds for use in the diagnosis, prevention and / or treatment of a
liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the
cholesterol level or
cholesterol uptake and, thus, diagnosis, prevention and / or treatment of a cardiovascular
disease. The present invention furthermore relates to an
in vitro or
in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and / or treatment of a
liver disease or condition, comprising administering a therapeutically effective amount of a
lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and / or treatment of a cardiovascular
disease.