945 results about "Infectious illness" patented technology

The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and / or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes a synthetic glycolipid compound of Formula I, as described herein. According to the present invention, the use of a compound of Formula I as an adjuvant is attributed at least in part to the enhancement and / or extension of antigen-specific Th1-type responses, in particular, CD8+ T cell responses. The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.

The invention discloses micro ribonucleic acids (microRNA, miRNA) carried by cell microparticles (Microparticle, MP), a method for preparing the same, and application thereof in the technical field of biotechnological pharmacy. The invention provides a combination of the micro ribonucleic acids for evaluating the physiological and / or pathological states of a participant, and the combination contains all the micro ribonucleic acids which exist stably in serum / plasma particles of the participant and are detectable. At the same time, the invention provides an experimental method for preparing the cell microparticles containing specific micro ribonucleic acids and using the cell microparticles to perform gene-level regulation and control as well as modification on other cells and tissues. The combination and the method can be used for detecting and treating various diseases, including the aspects of the diagnosis and the differential diagnosis of various tumors, various acute and chronic infectious diseases and other acute and chronic diseases, the prediction and the curative effect evaluation of the occurrences of disease complications and the recurrences of malignant diseases, as well as the active ingredient screening, the efficacy evaluation and the judicial authentication of drugs, the detection of prohibited drugs and the like; besides, the combination and the method have the advantages of wide detection pedigree, high sensitivity, low detection cost, convenient available material, easy storage of samples and the like.

Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the therapeutic agents modulate one or more signal transduction pathways induced by the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. In another aspect, the therapeutic agents modulate the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. The therapeutic agents can be used in the prevention, treatment and / or management of diseases in which it might be useful to modulate one or more immune functions (e.g., cancer, infectious disease, autoimmune disease, and transplantation rejection). In another aspect, presented herein are methods for identifying receptor-ligand interactions.

Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and / or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and / or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and / or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.

The invention discloses an epidemic situation predicting and early warning method of infectious diseases, particularly a network early warning system of relevant public health events of infectious diseases in countries, provinces, cities (regions) and districts (counties). The method comprises the steps of integrating adverse reaction information data which are collected by the server side, calculating and determining the early warning threshold of public health events according to the quantities of the symptoms of adverse reactions on the basis of the operation of a time sequence analysis statistic model and automatically carrying out early warning in real time at any time. The method comprises the following specific steps of: (1) integrating information from different channels; (2) executing a path I: analyzing tasks; and (3) executing a path II: predicting and early warning. Once the quantity of monitoring data meets the traditional basic requirements of a tome sequence analysis method for considering the periodicity, the seasonal nature, long term tend and the like of diseases, the conclusion having relative-high value can be obtained to play important roles of early finding epidemic situations, taking measures as soon as possible, preventing the spread of the epidemic situations and preliminarily establishing an epidemic situation monitoring and early warning system and a working mechanism of the province.

The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1 beta (IL-B) gene (IL-1B (-3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as periodontal disease and Alzheimer's disease.

Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and / or for the prevention, amelioration and / or treatment of disease, including, but not limited to, cancer and infectious disease.

The invention discloses an immunochromatographic test strip for full quantitative detection of C-reactive protein and a preparation method thereof. The test strip is composed of a sample pad, a mark pad, a coating film and absorbent paper which are successively overlapped and adhered on a baseplate, wherein the mark pad is coated with C-reactive protein (CRP) monoclonal antibody labelled by fluorescent latex particles and rabbit IgG labelled by fluorescent latex particles; and the coating film is composed of a detection region and a quality control region, and the detection region is coated with another CRP monoclonal antibody which is at different epitope with the CRP monoclonal antibody labelled by fluorescent latex particles. The C-reactive protein immunochromatographic test strip can perform sensitive quantitative detection on the full CRP in 10 seconds, can diagnose diseases and identify infection more rapidly and accurately, and can detect infectious illness state and determine the curative effect of antibiotics; and the full CRP has two detection results, namely hs-CRP and conventional CRP, comprehensive linear range and good detection sensitivity and less required sample amount, and is very convenient to operate.

An improved method (process) and medicinal composition is provided to treat herpes, pseudomonas, hepatitis, staph (staphylococci) and other infectious diseases The inexpensive medicinal composition can be self-administered and maintained for a prescribed time. The attractive medicinal composition can comprise a quaternary ammonium salt surfactant, a skin protectant and an alcohol. The quaternary ammonium salt surfactant can comprise benzalkonium halide, preferably benzalkonium chloride. The skin protectant can comprise Allantoin. The alcohol can serve as a pain reliever and can comprise benzyl alcohol. The medicinal composition can also include other compounds, additives, herbal extracts and / or carriers.

The present invention relates to probiotic Propionibacterium strains and their use in the preparation of probiotic supplements and foods. The invention relates to the provision of Vitamin B12, propionic acid, folacin and bacteriocins by probiotic strains, stimulation of bifidobacteria growth, production of favourable effects on the lipid metabolism and on the immune system of hosts through immunostimulation, immunomodulation or use of a probiotic strain as an adjuvant, reduction of homocysteine and β glucuronidase and the prevention, treatment or amelioration of conditions associated with a need for these activities. The probiotic bacteria of the invention can be used in humans or other animals. In at least some applications, the bacteria can be used dead and parts rather than whole cells may be used. The present invention also relates to the preparation of vaccines for use in protecting patients from infectious diseases, in particular tuberculosis.

The invention discloses a method for tracking close contact persons in an infectious disease epidemic situation. The method is a method for recording intimate contacts and establishing contact historyin a digital mode based on common non-contact equipment such as Bluetooth, a direct and indirect contact history relation graph of a confirmed patient can be drawn in an extremely short time, and coordination of epidemic prevention and control is facilitated. In addition to epidemic prevention and control, the method also has a plurality of other application scenes for assisting criminals in chasing and the like, and is of great social significance.

Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.

The invention relates to a city-wide infectious disease simulation method and a city-wide infectious disease simulation device. The method includes the steps of: 1) partitioning the city and classifying the people; 2) building a 4p ordinary simultaneous differential equation set which describes the dynamic process of the transmission of the disease in p (number) areas; 3) discretizing the equation set to obtain a difference equation set; 4) converting the discretized difference equation set into an open equation set by taking the connections of other cities into consideration; and 5) resolving the parameters of the equation set and visually expressing the infected people in the manner of dot density and piled bar graph. According to the epidemiological characteristics of the infectious disease and based on the data of interregional population flow across the city, the city-wide infectious disease simulation method and the city-wide infectious disease simulation device can predict and simulate the dynamic contagion process of the disease spatially in a period of time in the future, and the spatial propagation process of a typical infectious disease can be analyzed on a map in a visual way. The city-wide infectious disease simulation method and the city-wide infectious disease simulation device provide a decision support to infectious disease propagation prevention and control.

The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and / or treating an infectious disease with such molecules are provided.

An integrated, self-contained hand sanitizer station is provided by this invention. The enclosure of the station may be located in a public venue, and conveniently dispenses wet wipe towelettes for people to clean their hands with a trash receptacle contained within the station for ready disposal of the towelettes by the patrons after their use. By making a good hand hygiene available to customers, a merchant or public authority can help to reduce germs, viruses, and bacteria that can otherwise cause the spread of infectious illnesses.

The invention provides a method for constructing an infectious disease trend prediction model, an epidemic situation trend prediction method and device, electronic equipment and a computer readable storage medium. The method for constructing the infectious disease trend prediction model comprises the following steps: attenuating a basic infection number of an infectious disease according to propagation time to obtain effective infection numbers of a plurality of dates in a propagation period; determining fitting state data of the plurality of dates in one-to-one correspondence with the effective infection numbers of the plurality of dates in a state conversion relationship included in the infectious disease trend prediction model; extracting fitting case data of the plurality of dates fromthe fitting state data of the plurality of dates; and updating parameters of the infectious disease trend prediction model according to differences between the real case data of the plurality of dates and the fitting case data of the plurality of dates, and taking the updated parameters as parameters used for predicting an infectious disease epidemic situation trend based on the infectious disease trend prediction model. According to the invention, accurate modeling can be performed through combination with infectious disease data so as to support epidemic situation trend prediction based onthe infectious disease trend prediction model.

The invention provides a collagen and a collagen polypeptide, wherein, the weight percentage of hydroxylysine is more than 1.3 percent. The invention also provides the preparation technology and the application of the collagen and the collagen polypeptide. The invention can make full use of inexpensive raw materials including the fish skin and fish scale of tilapias to produce products with high added value. The collagen polypeptide is used for treating arthritis with a definite drug effect, and the clinical dose is considerably less than other collagen polypeptides. The collagen polypeptide can solve the pollution problem of fish skin wastes, and at the same time avoid the risk of infectious diseases which can be caused by the collagen of land animals. The collagen and the collagen polypeptide have the advantages of considerable economic benefits, energy conservation and environmental protection, simple process equipment, low cost and easy industrialization.

An exemplary embodiment providing one or more improvements includes feeding animals with probiotic microbes encapsulated in a mixture of xanthan gum and chitosan, or in gelatin, specifically Pediococcus acidilactici and Saccharomyces boulardii. Such encapsulation protects the viability of the probiotic microbes against unfavorable temperatures. An exemplary embodiment providing one or more improvements includes methods of using viable probiotics in therapy of birds and mammals infected with infectious diseases. Probiotics acted as adjuvants in stimulating antibody reaction and stimulated a cellular immunity response. In particular, probiotics were shown to reduce the number of viable oocytes from fecal samples, stimulate antibody production, and stimulate of proliferation of splenocytes in chickens infected with Elimeria. In addition, probiotics were shown to relieve symptoms of parvovirus infection in dogs.

A Chinese veterinary medicine in the form of injectino for treating infections diseases of livestock and fowls is prepared from 8 Chinese-medicinal materials including honeysuckle flower, forstyhia fruit, coptis root, phellodendron bark, etc through decocting in water and refining for removing impurities (tannin, protein, starch, resin, etc). Its advantages are high cure rate (more than 98%), no toxic by-effect, and no recurrence.

The present invention provides a method of improving or prolonging a subject's immune response to a vaccine composition comprising heat shock protein (HSP)-peptide complexes or alpha-2-macroglobulin (alpha2M)-peptide complexes (hereinafter "HSP / alpha2M vaccine composition"). The HSP-peptide complexes or alpha2M-peptide complexes of the vaccine composition comprise HSP(s) or alpha2M complexed to a component against which an immune response is desired to be induced. In particular the invention is directed to methods of improving or prolonging a subject's immune response comprising administering an HSP / alpha2M vaccine composition in conjunction with a preparation comprising HSP or alpha2M, alone or complexed to a peptide that is not the component against which an immune response is desired to be induced (hereinafter "HSP / alpha2M preparation"), i.e., the HSP / alpha2M preparation does not display the immunogenicity of the component. In particular, HSP / alpha2M vaccine compositions are administered in conjunction with HSP / alpha2M preparation to improve or prolong the immune response of a subject against an infectious disease or cancer.

An integrated, self-contained hand sanitizer station is provided by this invention. The enclosure of the station may be located in a public venue, and conveniently dispenses wet wipe towelettes for people to clean their hands without resort to soap and water. A trash receptacle contained within the station enables ready disposal of the towelettes by the patrons after their use. By making a good hand hygiene available to customers, a merchant or public authority can help to reduce germs, viruses, and bacteria that can otherwise cause the spread of infectious illnesses.

The invention discloses an epidemic infectious disease virus field visualization method based on space-time trajectory data. The method comprises the following steps: S1, airspread infectious diseaseurban diffusion modeling; s2, collecting, cleaning and processing space-time trajectory data and infection attack data of virus carrying crowds; s3, obtaining position semantic information of a viruscarrier; s4, calculating the virus distribution density by taking the virus carrier as the position center; s5, mapping the time, space and virus distribution density data of the virus carrying population; and S6, constructing an epidemic infectious disease virus field cloud platform based on temporal GIS. The invention further provides an epidemic infectious disease virus field visualization system based on the space-time trajectory data. According to the method, space-time trajectory data and infection attack data of virus carrying crowds are processed into a virus distribution density map with the virus carrier as the position center, spatial position semantic information is added and mapped to a temporal GIS, and an epidemic infectious disease virus field is visually processed.

The present invention relates to a novel bacteriophage, more precisely a Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious disease in human and animals, a pharmaceutical composition for the prevention and treatment of the disease caused by Staphylococcus aureus, an antibiotic and a disinfectant containing the bacteriophage as an active ingredient.

The invention relates to a mobile throat swab robot system, and specifically relates to a mobile throat swab sampling robot, a supporting system and operation software. The sampling robot is mainly used for the throat swab sampling operation of mobile detection points, so that doctors can achieve process interference and sampling position correction. The whole system can guarantee the separation of doctors and patients during throat swab sampling, can complete operations such as contact judgment, sampling quality judgment, throat swab sampling, throat swab head cutting and transferring and hand disinfection under fully automatic or partial manual intervention and can synchronously record data including but not limited to collection strength and positions, so that the influences of highly infectious diseases represented by the novel coronavirus on medical staff can be greatly reduced, physical and mental burden of the medical staff can be relieved, and medical resources such as protective suits and gloves can be saved; and the sampling robot can be directly connected to a mobile platform, so that the rapid moving of throat swab collection place construction and the collection and sampling of throat swabs can be realized.

Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and / or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and / or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and / or the antigen-presenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.

The invention discloses an early epidemic risk situation analysis method for an infectious disease based on an input-diffusion function, which comprises the steps of 1, identifying the scale of an infectious disease input risk source; 2, simulating a risk source propagation spread function; and 3, conducting short-term forecasting on the epidemic risk situation. According to the invention, population flow big data trend judgment and disease propagation and diffusion rules are fused; firstly, the morbidity differences of different regions are explored in the spatial dimension to describe the disease distribution pattern, and the inter-regional population flow scale and trend are analyzed based on population flow big data; then, the potential input risk case scale is measured and calculatedbased on the population flow; the function relationship between the number of potential input cases and the number of locally accumulatively diagnosed cases is counted; and the epidemic situation development characteristics and internal rules are revealed. The development of the epidemic situation is simply, rapidly and accurately monitored, the epidemic risk development situation in the future ispre-judged, and more accurate, more durable and more effective decision support can be provided for prevention and control of infectious diseases.

The present invention provides compositions and methods of immunotherapy to treat cancer or other antigen-producing diseases or lesions. According to one embodiment of the invention, a composition is provided for eliciting an immune response to at (east one antigen in a patient having an antigen-producing disease or lesion, the composition comprising an effective amount of a cytokine mixture, preferably comprising IL-1, IL-2, IL-6, IL-8, IFN-γ (gamma) and TNF-α (alpha). The cytokine mixture acts as an adjuvant with the antigen associated with the antigen-producing disease or lesion to enhance the immune response of the patient to the antigen. Methods are therefore also provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion utilizing the cytokine mixture of the invention. The compositions and methods are useful in the treatment of antigen-producing diseases such as cancer, infectious diseases or persistent lesions.