The invention discloses a MXene(Ti3C2)-loaded palladium catalyst and a preparation method and application thereof. The MXene(Ti3C2)-loaded palladium catalyst is prepared from a MXene(Ti3C2) carrier and palladium which is carried on the MXene(Ti3C2) carrier, the carried quantity of palladium accounts for 2-6 wt.% of the mass of the carrier, and the prepared MXene(Ti3C2)-loaded palladium catalyst isused for vanillic aldehyde catalytic hydrogenation to prepare 2-methoxy-4-methylphenol. According to the MXene(Ti3C2)-loaded palladium catalyst, after the palladium catalyst is carried, precious metal particles are small, the dispersity degree of the metal particles is high, the cost is low, the mechanical strength of the MXene(Ti3C2)-loaded palladium catalyst is good, and the stability of a catalytic cycle is good; the MXene(Ti3C2)-loaded palladium catalyst is used for the vanillic aldehyde catalytic hydrogenation to prepare 2-methoxy-4-methylphenol simply by using water as solvent of reaction, the cost is low, the preparation method is environmentally friendly, the toxicity is low, the yield of high, the technological processes are simple, and the operation is easy, which is conducive to industrial production; by using a gas chromatography mass spectrometer for qualitative and quantitive analysis, it is indicated that the conversion rate of vanillic aldehyde is 98%-100%, and the selectivity of 2-methoxy-4-methylphenol is 98%-100%.