32 results about "Benzylamine hydrochloride" patented technology

The invention belongs to the field of artificial synthesis of natural products and relates to an artificial synthesis method of a capsaicin homologue. The artificial synthesis method of the capsaicin homologue is to lead 4-hydroxy-3-methoxy-benzylamine hydrochloride to be reacted with the corresponding long-chain acid (E)-8-methyl-6-nonenoic acid and 8-methyl nonanoic acid or 7-methyl octanoic acid for preparing the capsaicin homologue. The long-chain acid synthesis method is characterized in that the method can avoid the use of triphenyl phosphine and other toxic substances which are commonly used in the existing patents and toxic substance-triphenyl phosphineoxide in byproducts, thereby being relatively environment-friendly. For different capsaicin homologues, the required starting raw materials are different. In particular, dihydrocapsaicin is applicable to large-scale industrial production.

This invention discloses a method for reducing the nitrabenzylamine compound to be nitrabenzylamine hydrochlorate whichreduces the nitrabenzylamine compound under hydrogen gas atmosphere by catalytic hydrogenation, using Pd-C / HCl catalytic system. This invention reduces the reaction activity of Pd-C catalyst by adding HCl or hydrochloric acid or CHCl3 which can produce HCl during the reaction to the reaction system, to entitle the Pd-C catalyst with the activity of catalyzing the nitro group of hydrogenated nitrobenzylamine compound to be amidol, without benzyl hydrogenolysis. This invention is characterized of simple operation, mild reaction condition, convenient treatment of post-production material, and broad application future.

The invention relates to a gastroendoscope cleaning product and in particular relates to a rectoscope washing agent. The rectoscope washing agent comprises the following raw materials: water, 2-hydracrylic acid, methacrolein, (2-hydroxyethyl)diisopropyl methylammonium bromide xanthene-9-carboxylic ester, 2,3,4,5,6-pentahydroxy-2-hexenoic acid-4-lactone, cetyl trimethyl ammonium bromide, bicyclo[2.2.1]heptyl-5-allyl-2-carbonitrile, N-(1-methyl-2-phenoxyethyl)-N-(2-chloroethyl)benzylamine hydrochloride, 3-[4,5-dihydro-1H-imidazole-2-ylmethyl-(4-methylphenyl)amino]phenol. The washing agent has a good and remarkable dirt removal effect, especially has a relatively good sterilizing effect while removing dirt generated in a rectal examination process and especially has a remarkable removal effect on three types of bacteria existent in rectums, so that the cleanness and the safety of a rectoscope are ensured on aspects of dirt removal and sterilization.

The invention discloses a B,N-codoped porous carbon nanosheet and a preparation method. The preparation method comprises the following steps: using bi-(2-chloroethyl)benzylamine hydrochloride as a rawmaterial, mixing with alkali liquor to prepare bi-(2-chloroethyl)amine; then, enabling the bi-(2-chloroethyl)amine to react with boric acid to obtain bi-(2-chloroethyl)amido boric acid; and under theprotection of nitrogen, pyrolyzing the bi-(2-chloroethyl)amido boric acid, successfully preparing the B,N-codoped porous carbon nanosheet. The prepared porous carbon nanosheet is high in B,N content,and large in specific surface area. While the porous carbon nanosheet is used as a super capacitor electrode material, the capacitive performance is high, the rate capability is good, and the cycle life is long. The preparation method is simple in operation, and efficient in economy, and capable of realizing the industrial production of the B,N-codoped porous carbon nanosheet.

The invention provides a preparation method of azelnidipine starting material ethylamine benzhydrylamine. The method comprises the step of using benzophenone and formamide as raw materials to carry out aLeuckart reaction. The catalyst of silicon dioxide is added into a reaction system, and thus the reaction time is drastically reduced, wherein the time is decreased to 3-4 h from 8 h, and therefore energy consumption is significantly reduced; the rough product yield of a compound II is dramatically increased and is up to 96-98%. The purity of HPLC is not lower than 96.5%, so that it is ensured that after the ethylamine benzhydrylamine obtained by hydrochloric acid hydrolysis is purified once, the yield can reach 80%, the purity is not lower than 99.9%, and the ethylamine benzhydrylamine is quite suitable for industrial production.

The invention provides a kind of preparation method of tetramisole hydrochloride, described preparation method, comprises preparation tetramisole; Described preparation tetramisole, 1,2-dibromoethylbenzene and 2-aminothiazoline hydrochloride react to generate tetramisole . The synthetic route of the present invention is shorter, and comprehensive yield is higher than other operational routes, with styrene as starting material, tetramisole free base is final product, and the yield of hydroxyl salt technical route is about 65%, N-(2- Chloroethyl)-α-(chloromethyl)-benzylamine hydrochloride process route has a yield of about 72%, while using this patented route, the yield can reach more than 85%. At the same time, it avoids the problems of multi-step reactions, such as chlorination, hydrolysis, cyclization, etc., resulting in a large amount of waste water and waste salt, and avoids the investment in reaction equipment such as autoclaves. It meets the requirements of green chemical industry, has significant economic benefits, and has a good industrialization prospect.

The present invention relates to a novel polymorphic form of N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride.

The preparation method of the drug detection equipment calibration product provided by the present invention comprises uniformly mixing p-benzylamine hydrochloride, pigment, anhydrous sodium carbonate and liquid paraffin to obtain a mixture, placing the mixture in an ultrasonic environment and heating it in a water bath, and The mixture heated in a water bath is treated at high temperature to exhaust the gas in the mixture, and the liquid part of the mixture is placed in a low-temperature environment for static molding to obtain the verification product of the drug detection equipment, which is provided by the present invention The preparation method of the calibration product of drug detection equipment is to mix the chemical calibration product into solid paraffin after deacidification treatment, and use the paraffin to slowly melt at high temperature to realize the slow volatilization of the calibration product, and then realize the gas phase calibration, which is easy to use and low in cost , easy to store and carry.

The invention discloses a method for preparing microsomal prostaglandin E2 synthase-1 inhibitor. Contains three steps: 1) 5‑iodoisatoic anhydride and 4‑(3‑chlorophenyl) benzylamine hydrochloride to prepare N‑substituted amide; 2) N‑substituted amide and crotyl alcohol to generate 3‑[( 3'-chloro[1,1'-diphenyl]-4-yl)methyl]-2-propyl-6-iodoquinazolone; 3) The product of the previous step reacts Goldberg with o-chlorobenzamide The amination reaction yields the target product. The preparation method has relatively simple steps, avoids the use of alkali and toxic chemical reagents, such as triphenyl phosphite, uses cheap and easy-to-obtain crotyl alcohol as a raw material, automatically transfers hydrogen, does not add alkali in the reaction process, and "one-pot" reaction Complete, the by-product is only water, the reaction atom economy is high, meets the requirements of green chemistry, and has broad development prospects.

The invention provides a preparation method of an Avanafil intermediate. The preparation method comprises the following steps: dissolving 4-hydroxy-2-methylthio-ethyl 5-pyrimidinecarboxylate and potassium carbonate in DMF to obtain a mixed solution, adding methanesulfonyl chloride into the mixed solution under the stirring condition, continuously stirring after addition until a reaction is ended, adding water and ethyl acetate into a reaction solution, carrying out extraction and liquid separation, carrying out vacuum concentration on an organic phase to prepare 4-methanesulfonic sulfonic ester-2-methylthio-ethyl 5-pyrimidinecarboxylate; dissolving the obtained 4-methanesulfonic sulfonic ester-2-methylthio-ethyl 5-pyrimidinecarboxylate into DMF, adding a (3-chloro-4-methoxy)Benzylamine hydrochloride to obtain mixed liquor, adding triethylamine into the mixed liquor under the stirring condition, continuously stirring after addition until a reaction is ended, adding water and ethyl acetate, carrying out extraction and liquid separation, carrying out vacuum concentration on an organic phase, and recrystallizing to prepare 4-(3-chloro-4-methoxybenzylamino)-5- ethyloxycarbonyl-2-methylthiopyrimidine. The invention has advantages of less environmental pollution, high product yield, safe post-processing and simple operation.

The invention discloses a novel method for preparing N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]methylsulfonyl benzylamine hydrochloride (I), which comprises: reaction of phenylamine and methanesulfonyl chloride to produce N-phenyl methanesulfonamide (II), reaction of the obtained compound (II) and chloroacetyl chloride to produce N-[4-[2-chloroacetyl phenyl]methanesulfonamide (III), reaction of the obtained compound (III) and isopropamide to produce N-[4-[2-(1-methylethyl)amino]acetyl]methylsulfonyl benzylamine hydrochloride (VI), and reduction of the obtained compound (VI) by sodium borohydride to produce the target product N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]methylsulfonyl benzylamine hydrochloride (I). The method has the advantages of low cost, short reaction procedures, simple operation, high yield, high product purity and the like, and is suitable for industrial production.