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212results about How to "Wide substrate applicability" patented technology

Method for synthesizing carbamate by using olefin, amine, carbon dioxide and Togni reagent

The present invention relates to a method for synthesizing carbamate by using an olefin, an amine, carbon dioxide and a Togni reagent. The method comprises: in a high pressure reaction kettle, sequentially adding an organic solvent, an olefin, an amine and a Togni reagent, adding a copper salt as a catalyst, introducing carbon dioxide, carrying out a stirring reaction for 5-24 h at a temperature of 40-100 DEG C, cooling to a room temperature after completing the reaction, slowly releasing carbon dioxide to achieve an atmospheric pressure, carrying out water washing on the reaction solution, extracting with ethyl acetate, drying with anhydrous magnesium sulfate, carrying out pressure reducing distillation concentration to obtain a crude product, and carrying out column chromatography purification to obtain the carbamate compound. According to the present invention, the synthesis method avoids the use of toxic raw materials such as phosgene or isocyanate, and the like, has characteristics of safe and simple operation, mild reaction condition, good functional group compatibility, wide substrate applicability and high yield, is suitable for industrial production, and has good application prospects in synthesis of pesticides, medicine, and natural products.
Owner:SOUTH CHINA UNIV OF TECH

3-p-*alkene-1-secondary amine type compound and preparing method and weeding application thereof

The invention discloses a 3-p-*alkene-1-secondary amine type compound and a preparing method and weeding application thereof. In the method, a 3-p-alkene-1-Schiff base type compound serves as the rawmaterial, in a polarity organic solvent, a reducing agent is put in batches at the temperature from -10 DEG C to 50 DEG C, reaction is conducted for 1-24 hours, reaction liquid is subjected to distilled water quenching, dichloromethane extracting, anhydrous sodium sulfate drying, filtering and depressurized distilling after reaction ends to obtain a crude 3-p-alkene-1-secondary amine type compoundproduct, and the column chromatography on silica gel is conducted to obtain a pure product. The growth injury symptoms of rice barnyard grass roots and stems are measured through a culture dish seedgermination method under the culture of the 3-p-alkene-1-secondary amine type compound with different concentrations, and the weeding activity of the compound is evaluated. The method is simple in process, mild in condition, high in speed, high in yield and wide in substrate application range, and the product 3-p-alkene-1-secondary amine type compound has a quite good restraining effect on the growth of the rice barnyard grass roots and stems.
Owner:INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY

Synthesis method of [60]fullerene dihydropyrrole derivative

The invention discloses a synthesis method of a [60]fullerene dihydropyrrole derivative, and belongs to the technical field of synthesis of fullerene derivatives. The synthesis method of the [60]fullerene dihydropyrrole derivative, disclosed by the invention, is characterized in that a specific process comprises the following steps: by taking [60]fullerene, a sulfonyl hydrazone compound and a nitrile compound as reaction raw materials, carrying out cyclization reaction at 110 DEG C to 120 DEG C under the acceleration effect of Ag (I) to prepare a target product, i.e., the [60]fullerene dihydropyrrole derivative. The synthesis process disclosed by invention has wide substrate applicability and relatively good functional group compatibility, and can be used for synthesizing fullerene macromolecular compounds; the reaction can be used for synthesizing raw materials, which are simple and easy to obtain, into the fullerene derivative with various substituent groups.
Owner:HENAN NORMAL UNIV

Method for synthesizing trifluoromethyl-containing carbamate by using carbon dioxide

The invention relates to a method for synthesizing trifluoromethyl-containing carbamate by using carbon dioxide. The method comprises the steps of sequentially adding an organic solvent, alkyne, amine and a Togni reagent into a high-pressure reaction kettle, and then adding copper salt serving as a catalyst and an organic compound containing nitrogen or phosphor serving as a ligand; after that, replenishing the high-pressure reaction kettle with carbon dioxide, and stirring for carrying out a reaction for 5-24h at the temperature of 40-80 DEG C; after the reaction is finished, cooling to the room temperature, slowly discharging carbon dioxide to normal pressure, washing reaction liquid with water, extracting by using ethyl acetate, drying by using anhydrous magnesium sulfate, and then carrying out reduced pressure distillation and concentration to obtain a crude product; then, purifying by means of column chromatography to obtain a trifluoromethyl-containing carbamate compound. The method for synthesizing the trifluoromethyl-containing carbamate has the advantages of being easy in obtaining of raw materials, safe and simple in operation, mild in reaction conditions, good in functional group compatibility, wide in substrate applicability, high in yield of target product, and the like, is beneficial to industrial production, and has potential application prospect in synthesis of pesticides and medicines.
Owner:SOUTH CHINA UNIV OF TECH

Novel beta-glucosidase and genes thereof and application of beta-glucosidase to glucoside synthesis

The invention provides a new protein with beta-glucosidase activity. A coding nucleic acid of the protein comprises an expression vector of the nucleic acid and a transformant containing the nucleic acid or the expression vector. The invention also provides an application of the new protein as a catalyst in catalyzing a monosaccharide and alcohol to carry out counter hydrolysis reaction to form glucoside. Compared with the traditional beta-glucosidase in almonds, the beta-glucosidase provided by the invention has better thermal stability, and compared with the beta-glucosidase from many other microorganisms, the beta-glucosidase provided by the invention can endure glucoses with higher concentrations and has a good industrial application prospect in glucoside synthesis.
Owner:EAST CHINA UNIV OF SCI & TECH

Polysubstituted tetrahydrofuran derivatives as well as synthesis method and application thereof

The invention relates to polysubstituted tetrahydrofuran derivatives and a chemical synthesis method thereof. The chemical synthesis method comprises the following steps: carrying out one-step reaction on raw materials (a diazo compound and a 3-hydroxyl-carbonyl flavone compound) in an organic solvent in the presence of a metal catalyst and an additive which is a molecular sieve shown in the specification; and carrying out column chromatography purification to obtain the target product. The chemical synthesis method of the polysubstituted tetrahydrofuran derivatives has the advantages of environmental benefit, step economy, atom economy, diastereoselectivity and high yield; in addition, the reaction conditions are mild, the applicability of the substrate range is wide and the operation is simple and safe. The invention discloses that the polysubstituted tetrahydrofuran derivatives with multiple chiral centers have PTPlB inhibiting effect; and therefore, the polysubstituted tetrahydrofuran derivatives are important chemical engineering, chemical and medical intermediates and have a wide prospect in the field of pharmaceutical chemicals.
Owner:EAST CHINA NORMAL UNIVERSITY

Iron-based catalyst for synthesizing compound with quinazolinone structure, and preparation method and application of iron-based catalyst

The invention belongs to the technical field of liquid phase oxidation, and discloses an iron-based catalyst for synthesizing a compound with a quinazolinone structure, and a preparation method and application of the iron-based catalyst. The iron-based catalyst mainly consists of carbon and nitrogen elements, wherein the weight ratio of various elements is as follows: 5-10 wt% of iron, 55-70 wt% of carbon and 1-20 wt% of nitrogen, and the particle size of the iron nano particles of the iron-based catalyst is 5-20 nm. The iron-based catalyst is prepared by taking a magnetic ion liquid as a precursor and sucrose as a carbon source, and carrying out pyrolysis in an inert atmosphere. In the presence of the iron-based catalyst in a very low usage amount, peroxide used as an oxidant and no otheradditives, the quinazolinone compound is synthesized by taking anthranilamide compounds and primary alcohols as raw materials. The iron-based catalyst provided by the invention is easy to synthesizemassively, has magnetism, can be recycled, and has the advantages of mild reaction condition, greenness, environmental protectiveness, easy separation of products, high selectivity and yield of products, and a good application prospect.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Cis-p-alkyl-1,8-disecondary amine compound, and preparation method and weeding application thereof

The invention discloses a preparation method and a weeding application of a cis-p-alkyl-1,8-disecondary amine compound. The method comprises the following steps: using cis-p-alkyl-1,8-diSchiff base compound as a raw material, adding a educing agent to a polar organic solvent in batches at a temperature of -10-50 DEG C, carrying out a reaction for 1-24 h, quenching the obtained reaction solution with distilled water after the reaction is finished, performing extraction with dichloromethane, drying the obtained extract with anhydrous sodium sulfate, filtering the obtained extract, carrying out reduced pressure distillation to obtain the cis-p-alkyl-1,8-disecondary amine compound, and performing recrystallization or silica gel column chromatography to obtain the pure product. The cis-p-alkyl-1,8-disecondary amine compound is detected by a culture dish seed germination technology, and the weeding activity of the compound is evaluated according to the growth injury symptoms of roots and stems of rice barnyard grass. The method of the invention has the advantages of simple process, mild conditions, high rate, high yield, and wide applicability of the substrate, and the product cis-p-alkyl-1,8-disecondary amine compound has an excellent inhibition effect on the growth of the roots and stems of the rice barnyard grass.
Owner:RES INST OF FORESTRY NEW TECH CHINESE ACAD OF FORESTRY +1
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