The invention discloses a no-clean nano-silver antibacterial hand sanitizer which is prepared by mixing the following raw material components in percentage by weight: 0.2 to 10 percent of a skin moisturizing humectant, 0.1 to 3 percent of a skin moisturizing agent, 0.0005 to 0.1 percent of nano silver and the balance of water, wherein the total weight percentage is equal to 100 percent. According to the no-clean nano-silver antibacterial hand sanitizer, no organic preservative is added, but only nano-silver is used as a preservative and antibacterial agent, so that the product has the preservative function, and also has the effects of resisting bacteria, diminishing inflammation and accelerating repairing of damaged skin; and besides, the no-clean nano-silver antibacterial hand sanitizer is quite strong in broad-spectrum bacteriostasis and sterilization effect, and can achieve a long-acting antibacterial effect. The nano-silver antibacterial hand sanitizer is mild, refreshing, non-irritating and low in damage to the skin, can effectively protect the tender skin of children, can be used by personnel outside under a condition of water shortage, and can protect the health of people.