39results about How to "Uniform and stable release" patented technology

The invention provides a water-retaining slow-soluble fertilizer and a preparation method thereof. The water-retaining slow-soluble fertilizer provided by the invention is composed of nutritional ingredients, a natural polymer with a water retention function and slow solubility and a modifier thereof. Further, the invention provides a preparation method of the water-retaining slow-soluble fertilizer. The method includes: mixing the nutritional ingredients, the natural polymer tamarind polysaccharide gum and the modifier thereof, and apatite by fusion, roller extrusion granulating, and drying and cooling to obtain a water-retaining slow-soluble fertilizer. The water-retaining slow-soluble fertilizer adopts a slow-soluble material with water-retaining property, thereby both being capable of keeping the moisture in soil to ensure sufficient moisture of a plant to promote the plant growth, and capable of being dissolved slowly to slowly release the nutritional ingredients so as to uniformly and stably release the fertilizer efficiency in the plant growth process. The water-retaining slow-soluble fertilizer is high in production efficiency, low in cost, easy to control the process and stable in controlled release, and can be compatible with crop growth rules to improve the utilization rate of the fertilizer.

The invention provides a progestin sustained-release microsphere and nanoparticle and a preparation method thereof and a progestin sustained-release injection. The preparation provided by the invention comprises progestin and biodegradable polymers PLGA, PLA, PCL and PGA; and the progestin microsphere is prepared by adopting an emulsion-solvent evaporation method and the progestin nanoparticle is prepared by adopting a nano-emulsification method in the process aspect. According to the prepared microsphere, the particle size is within a range of 10-20 microns, the drug loading capacity is 30-40% and the encapsulation efficiency is greater than 90%; and according to the nanoparticle, the particle size is within a range of 100-400nm, the drug loading capacity can reach 10-20% and the encapsulation efficiency is 80-90%. The progestin preparation requires frequent administration for multiple times; and the sustained-release injection has good correlation in vivo and vitro, the sustained-release effect of more than a week is reached, the medication compliance of a patient can be improved, and the living quality is improved.

The invention provides progesterone slow-release nanoparticles modified by PEG, a preparation method of the progesterone slow-release nanoparticles and a progesterone slow-release injection. A preparation provided by the invention comprises progesterone and biodegradable polymers PLGA, PLA, PCL, PGA and the like; in the process aspect, a nanoemulsion method is adopted to prepare the progesterone nanoparticles. According to the nanoparticles prepared by the preparation method disclosed by the invention, a particle size is in a range of 100 to 400nm, a drug-loading rate can reach 1% to 10%, and encapsulation efficiency is 80% to 100%. A progesterone listed preparation needs to be repeatedly and frequently administrated, but the progesterone slow-release injection provided by the invention has a higher biological utilization degree than market preparations and conventional progesterone nanoparticles, and reaches not less than one week of slow-release effect; compliance of medicine use of a patient can be improved; life quality is improved.

The invention relates to a compound alpha-ketoacid tablet free of talcum powder and a preparation process thereof. The conventional preparation process is changed without adding the talcum powder; the tablet prepared by the method has good compressibility, attractive appearance, high disintegrating speed, high dissolution rate, high stability in long-term placement and high medicinal safety. Wet granulation is performed separately according to the acidic and alkaline ingredients and the mass balance ratio of main medicines, i.e., a meta-alkaline ingredient, a meta-acidic ingredient and a nearly neutral ingredient are subjected to wet granulation separately, and then mixing, tabletting and coating are performed, so that the direct contact among the ingredients is avoided, long-term stable placement can be realized and the contents of the active ingredients are guaranteed. A disintegrating agent internal and external addition method is adopted in the formula, the content of polyethylene glycol is optimized, and no talcum powder or analogs with ingredients similar to the talcum powder are included in the formula, so that the problems of agglomeration phenomenon and larger viscosity in the granulation process are solved, and the safety in medication is guaranteed.

The invention discloses a preparation method of water-soluble essence slow-release cigarette paper. Cigarette paper wrinkling, tearing and dyeing can be caused by cigarette paper perfuming. The methodcomprises the following steps: a, preparing an essence emulsion: mixing 12-16 parts by weight of a water-soluble essence, 18-25 parts by weight of modified starch and 2-3 parts by weight of sodium alginate at normal temperature, adding 59-68 parts of water, stirring for 60-90 min under the action of pressurizing, homogenizing and stirring at the speed of 5000-10000 r / min to form closed microcapsules, and standing for 3 h to obtain the essence emulsion; b, mixing; and c, printing. An essence slow-release substance is added to the cigarette paper through one-step forming, and the cigarette paper is smooth in surface and free of wrinkles and tearing in the adding process. When the modified starch, the sodium alginate and the pullulan are combusted, peculiar smell is not generated, smoke is hardly influenced, the combustion performance of the cigarette paper is not influenced, and paper ash is white after combustion.

The invention discloses slow-release essence formed paper. In the prior art, formed paper perfuming has the defects that the air permeability is influenced and the production speed is low. The methodof the present invention comprises the steps of: a, preparation of essence emulsion; uniformly mixing the raw materials comprising, by weight, 25-35% of essence, 15-20% of maltodextrin, 1-2% of polyethylene glycol and 1-2% of sodium caseinate at normal temperature, adding the balance of water, stirring the mixture for 60-80 minutes under the pressurized homogenizing condition of 8000-10000 revolutions per minute, and carrying out standing treatment for 5 hours to obtain an essence emulsion; b, mixing; adding carboxymethyl cellulose accounting for 1-2% of the weight of the essence emulsion andpolyvinyl alcohol accounting for 2-3% of the weight of the essence emulsion into the essence emulsion, and mixing all the components to obtain perfumed coating liquid; c, printing paper. The slow-release essence formed paper disclosed by the invention is small in essence loss, uniform and stable in fragrance release and long in fragrance retention period, and particles do not fall off and are stably attached to the surface of the forming paper when the slow-release essence forming paper is used.

The invention relates to a preparation method of cigar-flavored cigarette paper. The method comprises the following steps of: uniformly dip-coating cigarette paper with a bacterial cellulose dispersion liquid on a coating machine during cigarette paper production, and performing drying by a quick low-temperature drying cylinder, tightly combining the bacterial cellulose dispersion liquid and the cigarette paper and achieving uniform distribution. With the burning and smoking of the cigarette, rich cigar aroma can be given to the smoke, the aroma is rich and full, the aftertaste is natural andcomfortable, the positive effects of improving the sweet feeling, thick feeling and richness of the smoke of the cigarette, reducing the irritation of the smoke and covering offensive odor are achieved, and the style characteristics of the cigar type cigarette can be stabilized and strengthened.

The invention provides a tobacco flavor enhancing fragrance essence for heat-not-burn cigarettes as well as a preparation method and application thereof. The fragrance essence is in form of clear liquor obtained by mixing and filtering a tobacco extract, a flavor enhancing monomer fragrance, a slow-release raw material, propylene glycol and glycerol, wherein the tobacco extract comprises an aromatic tobacco extract and a molecular distillate thereof; and the raw materials of tobacco comprises one or more than one of aromatic tobacco, Zimbabwe tobacco, burley tobacco, sun-cured tobacco and Virginia tobacco at will. The use comprises the following steps: tobacco threads are prepared into powder; carboxymethylcellulose sodium, microcrystalline cellulose, purified water and the glycerol are added into the powder; the obtained mixture is fully mixed with the tobacco flavor enhancing fragrance essence for the heat-not-burn cigarettes and shaped into a dough; the dough is sliced into the tobacco threads after being pressed into a flat shape in a rolling manner; and the tobacco threads are manually rolled into cigarettes after water balance. Proved by evaluation, the tobacco flavor enhancing fragrance essence can well enhance the flavor of the tobacco, enables the flavor to be more comfortable and more natural, increases the concentration, prompts the satisfaction degree and conceals offensive odors, thereby improving the experience and the enjoyment of a smoker.

The invention relates to faint scent type cigarette paper and a preparation method thereof. The faint scent type cigarette paper is prepared from, by weight, 5%-20% of tree moss extract, 2%-10% of a tobacco extract, 3%-10% of a fruit extract, 2%-6% of a modifier and the balance water. When the cigarette paper is produced, the faint scent type module essence is diluted by an ethanol solution, thenthe cigarette paper is uniformly dip-coated on a coating machine, and then the cigarette paper is dried by a rapid low-temperature drying cylinder, so that the faint scent type module essence and thecigarette paper can be tightly combined together and are uniformly distributed. With the burning and smoking of the cigarette, the smoke can be endowed with rich fresh aroma, the aroma is rich and full, the aftertaste is natural and comfortable, and the method has positive effects of improving the sweetness, the thickness and the richness of the cigarette smoke, reducing the irritation of the smoke and covering offensive odor.

The invention relates to a heating system (2) for heating carriers for baked goods, in particular baking trays (6), in a housing of an automatic baking machine installation (1). The heating system (2) has a plurality of gas-operated burners which are arranged at a distance from one another. The gas-operated burners are porous burners (3). The heating system (2) has a pivoting device (7) which allows a pivoting movement in any desired direction. The heating system (2) additionally has a running rail apparatus (15) on which the porous burners (3) are mounted such that they can move along a predefinable running direction. The heating system (2) also has at least one controllable drive apparatus with which the porous burners (3) and / or the supporting frame (8) can be moved. The heating system (2) can also have a sensor device for detecting process parameters of the heating system (2) and a control device which is connected to the sensor device such that data can be transmitted.

The invention provides a preparation method of monomenthyl ester, and mint cigarette paper and a preparation method thereof. The preparation method of monomenthyl ester comprises the following steps:dispersing menthol, non-volatile organic acid anhydride and 4-dimethylaminopyridine in an organic solvent, performing reflux, cooling, filtering and extraction via an aqueous sodium carbonate solutionsuccessively, then carrying out separating, and successively performing extraction via ethyl acetate, concentrating and reduced-pressure distillation to obtain the monomenthyl ester. During production of cigarette paper, an ethanol solution of the monomenthyl ester is used for uniformly dip-coating of the cigarette paper via a coating machine, and then the cigarette paper is dried by a low-temperature drying cylinder, so the monomenthyl ester and the cigarette paper can be tightly combined together, the monomenthyl ester is uniform in distribution and stable in properties. Menthyl ester compounds can be cracked to generate menthol at a low combustion temperature, so that the generation of non-target substances caused by high temperature is reduced, and the mobility of menthol into mainstream smoke is improved; and the generation of harmful components can be reduced under an oxygen-enriched combustion condition, and the release of the menthol is relatively uniform and stable, so the cooling feeling of the mint is consistent all the time when a prepared cigarette is smoked.

The invention relates to the technical field of home textiles, in particular to a preparation method of a silk quilt. The preparation method of the silk quilt comprises the following steps of (1) silkpreparation, (2) refining, (3) rinsing, (4) modification, (5) drying and (6) silk quilt preparation. The silk quilt prepared through the method is high in production efficiency, excellent and stablein quality, safe in operation process, easy and convenient to operate and capable of saving resources, compared with a traditional preparation process, the preparation process time is shortened, the production cost is reduced, the prepared silk is fragrant, pleasant, good in cotton bulkiness and tension and good in whiteness. Meanwhile, the health-care functions of antibiosis, mite prevention, insect prevention and the like are realized.

The invention discloses a mixture containing a slow-release saline compound, a composite phase-change material and asphalt and a preparation method of the mixture. The mixture containing the slow-release saline compound, the composite phase-change material and the asphalt is prepared from 2-3 parts of the slow-release saline compound, 0.75-0.9 part of the composite phase-change material, 5-6 parts of the asphalt and 100-110 parts of an auxiliary material. The preparation method of the mixture containing the slow-release saline compound, the composite phase-change material and the asphalt comprises the following steps that 1, the slow-release saline compound is prepared; 2, the composite phase-change material is prepared; 3, the asphalt mixture is prepared. According to the method, salt ingredients in the slow-release saline compound are gradually released out, chlorine salt cannot be released to the road surface at a time but gradually released to the road surface under the action of the road surface pressure and the pore water power due to the adsorption action of pelelith powder, the freezing point of the snow water on the road surface is lowered through the salt ingredients dissolved in snow water, an ice and snow melting effect is better under the condition that the road surface is iced in winter, and the problems of road ice and snow melting and driving safety in winter can be effectively solved.

The invention provides an implant as well as a preparation method and application thereof. The implant comprises an implant suture and a drug coating arranged on the surface of the implant suture, wherein the drug coating comprises a drug and a controlled release factor. According to the implant provided by the invention, the implant can achieve an effect of quantitatively and slowly releasing the drug so as to eliminate or reduce pain, inflammatory swelling, infection and other risks in the implantation process on the basis of ensuring that the implant can be smoothly implanted into the human body, and a high-efficiency treatment effect can be achieved at a small dosage; moreover, by modifying the surface of the implant suture, good adhesion is maintained between the implanted implant suture and the drug coating. The drug coating is sprayed onto the implant suture in a spray manner, so that the drug on the surface of the implant suture can be uniformly dispersed, and convenience is brought to uniform and stable release of the drug. The implant is simple in preparation method, readily available in raw materials and easy to realize and has excellent effects in aspects such as inflammation control and swelling subsidence.

The invention provides a dirithromycin enteric-coated tablet enteric coating. The dirithromycin enteric-coated tablet enteric coating is prepared from the following components in parts by weight: 60-70% of methacrylic acid-acrylate copolymer aqueous dispersion, 2-5% of titanium dioxide, 15-35% of triethyl citrate and 0-0.5% of talcum powder. The invention further provides a preparation method andprocess of the dirithromycin enteric-coated tablet enteric coating. The characteristic of uniform and stable release is achieved while stability of a dirithromycin enteric preparation is improved, thedirithromycin enteric-coated tablet enteric coating achieves the better similarity to a reference preparation, namely Dynabac in dissolution behavior, thus the domestic dirithromycin enteric preparation is broken through, and foreign post-marketing drugs are effectively substituted.

The invention provides a sheet special for a tobacco product and a preparation method thereof, capable of effectively improving the uniformity and stability of the smoke release amount of the tobaccoproduct in the heating process. The preparation method provided by the invention comprises the following steps: fully mixing smoke powder and water in a homogeneous reaction tank; weighing external fibers, pulping, dispersing through a homogenizing pump, adding into a homogenizing reaction tank, and uniformly mixing; adding an atomizing agent, and uniformly mixing; preparing an adhesive into a solution with the concentration of 2%, adding the solution into a homogeneous reaction tank, and uniformly mixing; weighing a compound reaction solution, wherein the compound reaction solution comprisesthe following components in parts by weight: 10-30 parts of an enzyme preparation, 5-8 parts of an enzyme promoter, 25 to 40 parts of honey, 10 to 20 parts of amino acid, 3-6 parts of lactic acid, and30 to 70 parts of water; step 8, adding the solution prepared in the step 7 into a homogeneous reaction tank, and uniformly mixing; reacting the mixed materials at the temperature of 70 DEG C to 130DEG C; dehydrating and drying; and rolling and forming, drying and slicing to obtain the sheet special for the tobacco product.

The invention relates to a preparation method for gliclazide tablet composition. The preparation method comprises the steps of 1, granulation, 2, drying, 3, whole granule total blending, 4, tableting and 5, packaging, wherein before preferable feeding, characters of original auxiliary materials are inspected, and blocking and foreign matter phenomena should not exist; if the phenomena exist, raw materials and internally-added auxiliary materials are screened by 80-mesh stainless steel meshes, and externally-added auxiliary materials are screened by 20-mesh stainless steel meshes. The preparation method is simple in technology, operable, high in technological controllability, and suitable for industrial mass production; meanwhile, due to the fact that the gliclazide raw materials with the fineness below 80 meshes are selected, it can be ensured that products are uniformly and stably released, meanwhile, the products are uniform in quality and good in stability, differences between batches are small, and the reproducibility is good.

The invention provides a uniform atomization and variable application system for liquid medicine of a plant protection drone, and belongs to the technical field of plant protection drones. In the uniform atomization and variable application system for liquid medicine of the plant protection drone, a main control terminal is fixedly connected with a center plate of a power system, the center plateof the power system is fixedly connected with the top of a tripod, the right end of a combustion chamber of a variable smoke discharge system is communicated with the left end of a transition chamberof a smoke release system, a carburetor and combustion chamber of the variable smoke discharge system are fixedly connected with the upper side of a support rod V in the tripod, a smoke cylinder of the smoke release system is fixedly connected with a support plate of the tripod, and the amount of the liquid medicine output by a variable pump in the variable smoke discharge system, the rotation speed of a fan in the smoke release system, the opening degree of a smoke return port adjustment baffle plate, the temperature of an thermal insulation resistance wire and the opening degree of the a smoke release port adjustment baffle plate are all controlled by the main control terminal. The uniform atomization and variable application system for liquid medicine of the plant protection drone can be adopted to achieve simultaneous covering of the front and back of leaves of crops and trees with liquid medicine, ensure the smoke temperature at a smoke discharge port, achieve the uniform and stable release of smoke, and achieve the purpose of medicine spraying for prevention and control.

The invention relates to a paroxetine hydrochloride sustained release tablet and belongs to the technical field of pharmacy. According to a technical scheme, the paroxetine hydrochloride sustained release tablet is composed of a sustained release micro-pellet and common excipients. The sustained release micro-pellet is composed of a medicine-carrier layer, a sustained release layer and an enteric layer. The use amount of talcum powder in the sustained release layer is 20-100% of a high-molecular sustained release material in the layer. The use amount of talcum powder in the enteric layer is 50-200% of a high-molecular enteric material in the layer. Through regulation on the use amount of talcum powder, an effect of shading protection on the active component is achieved.

The invention provides a PEG-modified progesterone nanoparticle, its preparation method and progesterone sustained-release injection. The preparation provided by the invention includes progesterone and biodegradable polymers PLGA, PLA, PCL, PGA, etc.; technical aspects Progesterone nanoparticles were prepared by nanoemulsion method. The diameter of the nanoparticles prepared by the invention is in the range of 100-400nm, the drug loading can reach 1%-10%, and the encapsulation efficiency is 80%-100%. Progesterone marketed preparations need multiple frequent administration, and the progesterone sustained release injection provided by the present invention has higher bioavailability than commercially available preparations and traditional progesterone nanoparticles, and has achieved a sustained release effect of more than one week, which can Increase patient medication compliance and improve quality of life.

The application provides an enteric coating for dirithromycin enteric-coated tablets, comprising the following components in parts by weight: methacrylic acid-acrylate copolymer aqueous dispersion 60-70%; titanium dioxide 2-5%; citric acid Triethyl ester 15‑35%, talc 0‑0.5%. The preparation method and coating process thereof are also provided. While improving the stability of dirithromycin enteric-coated preparations, it achieves the characteristics of uniform and stable release, and achieves a better similarity to the dissolution behavior of the reference preparation Dynabac, thus achieving a breakthrough in domestic dirithromycin enteric-coated preparations , to effectively replace foreign listed drugs.

The invention provides a solid fumigation sterilizer. The solid fumigation sterilizer comprises a casing, a fumigation agent container and an ultrasonic generation device, wherein the casing is of a semi-enclosed opening structure; the fumigation agent container is arranged at the opening part of the casing; the fumigation agent container and the casing jointly define an accommodation space; the fumigation agent container is provided with an air outlet; the ultrasonic generation device is arranged in the accommodation space and is fixedly connected with the inner wall of the casing; the ultrasonic generation device is attached to the outer side of the bottom of the fumigation agent container. According to the solid fumigation sterilizer provided by the invention, a solid disinfectant in the fumigation agent container is subjected to ultrasonic dispersion by the ultrasonic generation device to release sterilizing active ingredients which are dispersed to the outside by the air outlet. The disinfectant disclosed by the invention disperses and releases the sterilizing active ingredients to the air under the action of the ultrasonic generation device for all-round sterilization of thespace without dead angles. In addition, after sterilization is finished, a treatment mode is simple and only ventilation is needed. Meanwhile, by using a solid fumigation agent, the weight of the device is reduced and the device is convenient to carry.

The invention relates to the technical field of powder metallurgy, and discloses a spark plasma sintering system for powder metallurgy. The system comprises a bottom plate, a loading frame is arranged on the bottom plate, a sintering chamber is arranged on the loading frame, a die pressing mechanism is arranged on the sintering chamber, and the die pressing mechanism is used for shaping raw material powder; two hydraulic cylinders are symmetrically arranged on the loading frame; and a first through hole is further formed in the sintering cavity, a vacuum pump is arranged on the bottom plate, and a first pipeline is arranged on the vacuum pump. According to the spark plasma sintering system for powder metallurgy, the upper electrode and the lower electrode generate discharge plasma, discharge impact pressure and Joule heat, extra pressure is applied to raw material powder through the two hydraulic cylinders; and the forming speed of the raw material powder can be increased, and the whole-process intelligent operation of the sintering process is achieved through a control system composed of a terminal module, an execution module and a measurement module.

The invention provides a sugarcane vinegar aromatherapy agent and a preparation method thereof, and relates to the field of aromatherapy technology. The sugarcane vinegar aromatherapy agent of the present invention is composed of the following raw materials in parts by weight: 4-9 parts of citronella, 8-12 parts of compound essential oil, sugarcane vinegar 15-22 parts, 2-4 parts of sodium alginate, 1-3 parts of isopropyl myristate and 3-5 parts of ethylene glycol; the sugarcane vinegar aromatherapy agent of the present invention adopts natural plant essence, which is green, environmentally friendly, safe and healthy , each raw material can synergize and promote each other, can emit a pleasant smell, relieve fatigue and accelerate human metabolism, in addition, the obtained aromatherapy agent also has the effect of anti-inflammation, sterilization, and inhibition of virus growth, and the aromatherapy agent release speed of the application It is slow and lasts for a long time, and the cost of use is reduced under the premise of ensuring the effect.