38results about How to "Unchanged" patented technology

The present invention relates to novel Fc variants that immuno-specifically bind to an Eph receptor. The Fc variants comprise a binding region that immunospecifically binds to an Eph receptor and an Fc region that further comprises at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc ligand (e.g., FcγR, C1q). Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and / or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants that immunospecifically bind to an Eph receptor, particularly for therapeutic purposes.

A composite adsorptive filter material containing porous aerogel is prepared through proportionally mixing ethyl n-silicate, alcohol, water and HF, stirring, laying aside to obtain wet SiO2 gel, immersing the wet SiO2 gel and fibers or fabric in the solution mixture of trimethyl chlorosilane and n-hexane for modifying, and heat treating at 100-200 deg.C.

The invention relates to composite modified pitch used for high-grade highways and a preparation method thereof. The technical proposal is as follows: firstly, 10-45 weight percent of concocted coal pitch and 55-90 weight percent of petroleum pitch are mixed uniformly by a colloid mill to be heated up to 120-220 DEG C; 1-10 weight percent of the above mixed material of styrene-butadiene-styrene block copolymer and 0.1-0.3 weight percent of stabilizing agent are added to be mixed for 0.5 to 2 hours at the temperature as above; and then the materials are stirred and kept warm in a development tank for 2 to 8 hours and then are placed in a storage tank. The concocted coal pitch is prepared by the step as follows: 40-70 weight percent of mesothermal coal pitch and 30-60 weight percent of coaltar or coal tar distillation cut or 85-95 weight percent of the mesothermal coal pitch and 5-15 weight percent of phenolic resin are added into a reactor to be mixed for 0.5 to 3 hours at 100-160 DEGC. the invention has low cost and simple technology, and a product has the characteristics of unlikely crack at low temperature, uneasy softening at high temperature, good elasticity, high strength and long service life.

The invention relates to a valve comprising a housing (1), a solenoid (5) arranged in the housing (1), a pin (7) that can be moved by the solenoid (5), a cup-shaped piston (8) which is connected to the pin (7), and a seal (14) arranged in the housing (1) for sealing the piston (8) against the housing (1). The seal (14) is a disk having a radially internal sealing surface (15), which is clamped atthe radially outer edge in the housing (12, 11).

The invention discloses a recording system and a method based on one-way hash function. The system comprises a user terminal, a center server and an authentication server. The method comprises that: the user terminal records a record file and initializes an information authentication key and a map code; when the authentication server requests the user terminal for a record unit corresponding to an operation course, the user terminal calculates a test value by using the one-way hash function, and transmits the test value and a map code sequence back to the authentication server; the authentication server authenticates the accuracy of the test value and the map code sequence through the center server; and the center server checks that a phase of the map code sequence acquired by hash calculation is equal to the test value through the one-way hash function so as to check that the record file of the user terminal is not subjected to modification.

The invention discloses a production process for the insulating layer of railway signal cables, which relates to the field of signal cables; mixing nano-titanium dioxide modified polyvinyl chloride, dibutyl hydroxytoluene, corundum modified polycarbonate and isoprene rubber evenly, and using high-speed Stir with a mixer, then stir in the potassium cyanide solution of basic copper carbonate, centrifuge, add to the calcium chloride solution after drying, add tert-butyl-4-hydroxyanisole, dicumyl peroxide, Acetate-nitrocellulose and 2-methyl methacrylate are stirred, and finally boron fiber, nano-alumina and methyl methacrylate-n-butyl acrylate-sodium allyl sulfonate are added, ball milled, and saturated vapor pressure of sesame oil is added Medium fumigation, sent to the extruder for extrusion molding; the prepared insulating layer has high strength, good aging resistance, good corrosion resistance and longer service life.

The invention discloses a synchronous grouting material used for a tunnel and a preparation method thereof. The grouting material is the grout which is prepared by taking sediment grout as a main raw material, wherein the sediment grout comprises 30 to 65 percent of clay and fine sand totally and the weight ratio of soil to sand in the sediment grout is 0.1-0.18:1; and adding 80 to 120 kg of cement, 300 to 450 kg of coal ash, 200 to 500 kg of water or mud water and 3 to 10 kg of sodium carboxymethyl cellulose into per cubic meter of the sediment grout, wherein the grout density is between 1.85 and 2.05 g / cm<3> and the grout consistency is between 10.5 and 12 cm. In the preparation method, sediment and the mud water generated in a construction process are adopted as grouting materials, so that the sediment and the mud water can be changed into treasure from waste; and therefore, the preparation method has the characteristics of great reduction of the dosage of high-energy consumption cement, capability of working inside and outside tunnels, and convenient construction.

The invention discloses a protection and reinforcement solution for ancient silk weaving cultural relics, which contains the following raw materials in the mass ratio: alcohol ether carboxylate: 0.05%-0.5%, sodium dodecylbenzenesulfonate 0.05%-0.05% 0.5%, 0.08-0.12% fatty alcohol polyoxyethylene ether, 0.2%-0.3% cyclodextrin, 0.2%-0.3% isingassing gum, 0.1%-0.2% bletilla striata gum, and the rest is deionized water. The invention also discloses a preparation method of the protection and reinforcement solution and a protection and reinforcement method when it is applied to ancient silk cultural relics. The reinforcing material of the present invention has a good effect of reinforcing the silk cultural relics, and can be directly applied before unearthing the unearthed silk cultural relics. After the reinforcing material of the present invention is fully infiltrated and solidified, a protective film can be formed between layers of fragile unearthed silk cultural relics, so that no adhesion occurs between layers of silk cultural relics, the original state of silk cultural relics is not changed, and it is non-toxic and pollution-free.

An impregnating solution for preparing hydrocatalyst contains at least two metal components in VIB family and at least one metal component in VIII family. It is prepared through dissolving a water-soluble Mo-contained compound in water, and adding organic carboxylic acid, the compound containing metal in VIB family and the salt containing metal in VIII family. Its advantages are high stability and no irritative volatile component.

The invention discloses a chordoma cell line and application thereof and belongs to the field of oncobiology. The preservation number of a human chordoma cell line (BHC2) is CGMCC (China General Microbiological Culture Collection Center) NO: 5321. The cell line is obtained by separating culture in a chordoma tissue cut from a basicranial chordoma patient operation and is subjected to in vitro subculture for over 14 passages. The cell has the biological characteristics of a notochord-derived cell that the cells are physaliphores arrayed in a cord shape under an optical microscope and a large amount of cavity structures exist in cytoplasm under the transmission of an electron microscope; and the cells expresses various marker proteins of the notochord-derived cell, namely Brachyury, S100, Galectin-3 and Fascin-1. The cell has the tumor characteristic that chromosome is of a heteroploid karyotype; the percentages at each phase of a cell cycle are as follows: 51.3 percent at G1 phase, 23.6 percent at S phase, 25 percent at G2-M phase and the ratio of the G2 to the G1 is approximate to 2, and thus the cell proliferation feature of tumor cells is shown; and the cells obtain tumorigenesis ability after being injected into a nude mouse body. The chordoma cell line can be cultured in vitro for a long term and keeps the cell stability unchanged and is a powerful tool for researching a targeted chordoma tumor medicament.