The invention provides an
epinastine hydrochloride transdermal patch. The
epinastine hydrochloride transdermal patch is composed of a back lining layer, a
drug containing layer and a anti-adhesion layer, wherein the
drug containing layer is composed of, by weight percentage, 0.5-10% of
epinastine hydrochloride, 60-90% of pressure-sensitive adhesives, 5-20% of
plasticizer and 4-30% of transdermal
enhancer. The preparation method of the epinastine hydrochloride
transdermal patch comprises stirring and dissolving the
plasticizer and the transdermal
enhancer, sequentially add in and uniformly mixing the epinastine hydrochloride and the pressure-sensitive adhesives, performing degassing and
drying processes, applying anti-adhesion materials to form the anti-adhesion layer,
drying the anti-adhesion layer and covering the back lining layer to obtain the epinastine hydrochloride transdermal patch. The epinastine hydrochloride transdermal patch is prepared by mixing and matching water-
soluble polymer materials and main drugs and is low in dosage; the epinastine hydrochloride transdermal patch can be prepared into thin patches, which are stable in properties, safe, free from
irritation and good in
skin tolerance; compared with traditional oral medicines, the epinastine hydrochloride transdermal patch is good in effects, beneficial to absorption by patients and capable of avoiding first-pass effects of liver of the patients.