The invention discloses a synthesis method for 2,2,4,4,6,6-hexanitro-adamantane. According to the method, diethyl malonate is used as a raw material, and the steps of cyclization, ozonization and the like with complex aftertreatment and low yield in the traditional route are avoided by a new route; and in the new route, N2O5 is used as a nitration agent in a nitration step, and the advantages of fast reaction speed, easily-controlled reaction temperature, easily-separated products, high product purity, capacity of effectively reducing waste acid, and the like are achieved. The method is lower in cost, less in reaction pollution and higher in yield compared with the traditional route, the reaction yield is increased to 14% from 0.5% of the original route, and possibility is provided for industrialized production for 2,2,4,4,6,6-hexanitroadamantane.