36results about How to "Overcome barriers" patented technology

Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.

Shortcomings in conventional Very High Frequency (VHF) Digital Link Mode 3 (VDL-3) communication techniques for implementing air / ground (A / G) diversity site group (DSG) communication are identified and resolved. Beacon schedules are used to coordinate the use of VDL-3 TDMA management slots. Limited autonomy local address management techniques are used to distribute blocks of unique addresses to the ground stations (GS's) of a DSG from a common base of local addresses maintained at a control site, thus assuring that the respective ground stations assign a unique local identifier to each aircraft supported by the DSG. Aircraft supported by a DSG are polled to obtain time of arrival (TOA) and signal quality information used to: intelligently select the transmit ground station and the receive ground station used for communication between an specific aircraft and the control site; and, intelligently manage contiguous communication handoffs of aircraft from one ground station to another ground station of the DSG.

The present invention discloses a method for implementing data integration and data service based on a panoramic business model of the power grid, and relates to the technical field of power system information. The method for implementing data integration and data service based on the panoramic business model of the power grid comprises that: by scheduling various business systems, all levels of systems and various departmental system data, modeling tools and data extraction tools are unified, and data is collected and processed to provide data services in a microservice frame manner. According to the method disclosed by the present invention, by relying on the panoramic business model of the power grid, integration of the scheduling domain data is implemented, the barriers between various business application systems are overcome, a unified and standardized scheduling data mart is established, unified data support is provided for the reporting module and other application modules, problems that the information data of the grid system is inaccurate, non-uniform and inconsistent are avoided, and efficient and convenient data management functions are provided.

The invention discloses a networking system and a networking method. The networking system comprises a platform server, a router, a first intelligent household appliance and a second intelligent household appliance, wherein the router is connected with the platform server, and the first intelligent household appliance and the second intelligent household appliance are communicated with the router. The platform server is used for transmitting a first operation strategy to the first intelligent household appliance, and the first intelligent household appliance is used for performing operations corresponding to the first operation strategy after receiving the first operation strategy; and / or, the platform server is used for transmitting a second operation strategy to the second intelligent household appliance, and the second intelligent household appliance is used for performing operations corresponding to the second operation strategy after receiving the second operation strategy. According to the networking system and the networking method, the first intelligent household appliance and the second intelligent household appliance are connected to the platform server, and the platform server transmits the operation strategies to the first intelligent household appliance and the second intelligent household appliance, so that barriers formed among different household appliance manufacturers can be overcome, information sharing of each intelligent household appliance is achieved, and uniform control of the first intelligent household appliance and the second intelligent household appliance is implemented through the transmitted operation strategies.

The invention discloses an assembler for different OSes and an assembly transplantation method and relates to the field of computer code transplantation. The method comprises obtaining source codes, encoding the source codes and obtaining source assembly programs; selecting target OSes and converting the source assembly programs into target assembly programs in accordance with assembly formats according to the assembly formats of the target OSes; obtaining application program binary system interface specifications of the target OSes and converting target assembly programs into novel target assembly programs in accordance with the application program binary system interface specifications; for the target OSes, packaging the novel target assembly programs to complete assembly transplantation. By means of the assembler, executable assembly programs towards different target OSes can be converted, and accordingly, code transplantation difficulties caused by different OSes are overcome.

The invention specifically relates to polypeptide essence having efficacy of relieving allergy and repairing skin and a preparation method of the polypeptide essence. The essence is an aqueous system,a micromolecule peptide composition is used as a core and is compounded with a plant extract having the efficacy of relieving allergy and a plant extract having the efficacy of repairing skin, wherein the micromolecule peptide composition comprises oligopeptide, oat peptide and copper tripeptide-1, the plant extract having the efficacy of relieving allergy comprises trehalose, an opuntia streptacantha stem extract and a radix ophiopogonis root extract, and the plant extract having the efficacy of repairing skin comprises a harba dendrolii nobilis stem extract, a radix sophorae yellowish sophora root extract, a lycium barbarum fruit extract, a pseudo-ginseng root extract, an astragalus membranaceus root extract, a glossy privet fruit extract and a licorice root extract. The prepared essence has the double functions of relieving allergy and repairing skin, is safe and mild and can solve the sensitive skin problems that skin flushes, and turns red and swollen caused by weather, geographical environment, and improper use of skin care products.

The invention discloses a compound anti-aging quercetin nanoemulsion health care product which comprises the following raw materials in mass percent: 1-15% of quercetin, 15-40% of surfactant, 1-15% of cosurfactant, 5-25% of oil, 1-15% of celery aqueous extract, 1-15% of mushroom aqueous extract, and the balance of distilled water; and the sum of mass percents of the above raw materials is 100%. The nanoemulsion is small in emulsion droplet, uniform in distribution, low in viscosity and good in liquidity. The compound anti-aging health care product takes fat soluble natural product quercetin with an efficient anti-aging effect as a main component, takes the celery aqueous extract and the mushroom aqueous extract as auxiliary components, has effects of keeping skin moisture, adjusting slumber, delaying senescence and adjusting immunologic function and has certain health care effect on diseases such as hypertension, hyperlipemia, hyperglycemia, heart disease and the like.

The invention provides a metal surface treatment method which mainly comprises the following steps of: anodic oxidation treatment, pattern making, hole sealing treatment and polishing treatment. The metal surface treatment method provided by the invention can be used for manufacturing a surface ornamentation layer with ceramic appearance and tactile sensation on the surface of a metal workpiece, so that the metal workpiece has better surface appearance and property and can be better applied to the ornamentation of the shell of a digital product.

The invention discloses a transdermal absorption composition and application of the same to preparation of a transdermal absorption preparation. The transdermal absorption composition comprises a sponge bone needle and nanoparticles. Since the sponge bone needle and the nanoparticles containing drugs and / or cosmetics are used in combination, the keraphyllous barrier of skin can be overcome, and the sustained release and controlled release characteristics of a variety of nanoparticles can be utilized to prolong the release of the active ingredients of the drugs or cosmetics, improve the stability of the active ingredients, reduce the toxic and side effects and skin irritation of the active ingredients, etc.; and thus, more efficient, more stable and safer transdermal absorption of a seriesof biomacromolecules such as the active ingredients of the drugs and cosmetics are promoted.

The invention relates to the technical field of fundus image analysis, mobile medical treatment and health service, and particularly relates to a mobile medical personalized health service method andsystem. The mobile medical personalized health service method comprises the steps: obtaining to-be-analyzed information, preprocessing the to-be-analyzed information, and performing optic disc positioning and macular foveal fovea positioning on a preprocessed fundus image; segmenting a retinal vessel network and a main vessel of the preprocessed fundus image; extracting and identifying retinal feature data of the fundus image, forming a structured quantitative index of the retinal feature data, and analyzing and processing the structured quantitative index of the retinal feature data; and performing interactive information exchange and processing with a remote terminal mechanism and the user. The method can realize personalized health services.

The invention discloses a propranolol-eugenol type basil oil nano-emulsion medicament, which consists of the following raw materials in percentage by mass: 1-10 percent of propranolol, 10-30 percent of surfactant, 0-25 percent of cosurfactant, 1-15 percent of eugenol type basil oil and the balance of distilled water, wherein the mass percentage sum of the raw materials is 100 percent. A nano-emulsion has the characteristics of small emulsion drop particles, uniform distribution, low viscosity and high flowability. In a nano-emulsion dosage form, propranolol serving as a water-soluble medicament is organically combined with fat-soluble eugenol type basil oil, so that the dissolving and permeation capabilities of eugenol type basil oil are increased, and the stability and medicament effect of propranolol are enhanced. After the propranolol and the eugenol type basil oil are prepared into a nano-emulsion dosage form, the advantages of the propranolol and the eugenol type basil oil are combined, the hypertension resisting effect is enhanced remarkably, the half-life period of a medicament is prolonged, and the administration times are reduced.

The invention discloses medicine extract submicron emulsion gel. The medicine extract submicron emulsion gel is prepared from the following raw materials in parts by weight: 20 to 50 parts of cortex moutan, 20 to 50 parts of rhizoma chuanxiong, 10 to 40 parts of safflower, 5 to 60 parts of herba selaginellae and 5 to 60 parts of herba geranii; the medicine extract submicron emulsion gel further comprises 50mg / g to 300mg / g of a medical oil phase, 5mg / g to 50mg / g of an emulsifier, 1mg / g to 50mg / g of an assistant emulsifier, 0.1mg / g to 35mg / g of a stabilizer, 0.1mg / g to 20mg / g of an antioxygen, 5mg / g to 50mg / g of a gel matrix and 0.5mg / g to 3mg / g of a preservative. The medicine extract submicron emulsion gel has the effects of promoting flow of qi and blood circulation, expelling wind and detoxifying, clearing heat and expelling dampness and is used for treating targeted medicine erythra, radiodermatitis and chemotherapeutic extravasation and has high effective rate, small toxic side effect and short course treatment.

A percutaneous absorption composition comprising a sponge bone needle and nanoparticles, and uses thereof in the preparation of a percutaneous absorption preparation are disclosed. Release of active ingredients of drugs or cosmetics is prolonged by utilizing the slow and controlled release characteristics of various nanoparticles, the stability of the active ingredients of drugs or cosmetics is improve, and toxic side effects and skin irritation of the active ingredients of drugs or cosmetics are reduced while the percutaneous absorption composition overcomes the skin stratum corneum barriers.

The invention discloses a white-tea self-heating facial mask and a preparation method thereof. The white-tea self-heating facial mask comprises a compressed facial mask base cloth and facial mask essence, wherein the facial mask essence comprises 1-3 parts of a hydrating agent, 1-3 parts of a penetrating agent, 20-50 parts of a white tea extract, 5-10 parts of EGCG nanometer liposomes, 1-3 parts of plant essential oil, 1-3 parts of a pH buffering agent, 5-10 parts of a thickening agent, 0.5-1 part of a preservative and 1-3 parts of a composite synergist, and the compressed facial mask base cloth comprises 5-20 parts of baking soda and 50-70 parts of a fruit fiber film material. When being used, the white-tea self-heating facial mask can generate heat and is comfortable to use, and throughcooperation with the facial mask essence, the absorption of skin for nutrient substances can be improved, the antioxidant ability is high, and the moisturizing properties are high.

An oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is a nanoemulsion medicament with cefazolin and an aqueous clove extract as effective components, and comprises the following components in parts by weight: 1-15 parts of cefazolin, 10-30 parts of a surfactant, 0-25 parts of a co-surfactant, 1-10 parts of aqueous clove extract, 1-20 parts of oil and 20-70 parts of distilled water. By compounding the cefazolin and the aqueous clove extract, the oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is good in medicinal effect and good in antimicrobial effect; a preparation method is very simple; the oil-in-water compound antimicrobial cefazolin nanoemulsion medicine is easier to popularize.

The invention discloses a disaster relief base station and rescue system based on an ad-hoc network, and the method comprises the steps: enabling cable car power devices of adjacent base stations to be connected through a cable rope when a natural disaster happens, and enabling a rescue cable car to be assembled on the cable rope; and communicating the relay rooms of any two base stations through a three-channel pipe, and arranging a water pipe (1), a communication line (3) and a power line (4) in the three-channel pipe. The rescue base stations are interconnected through the ad hoc routers in the relay room to form an ad hoc network, the ad hoc network has no strict control center, the positions of all nodes are equal, the nodes can join in in and leave the network at any time, operation of the whole network cannot be affected by faults of any node, and the rescue base stations have high survivability, the barrier of network coverage in remote mountainous areas is overcome, and the reliability of the whole rescue system is improved. According to the invention, remote monitoring can be realized, quick response and decision deployment of related management departments are facilitated, and the rescue timeliness is further improved.

The invention discloses an external traditional Chinese medicine ointment for treating myopia and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine ointment comprises rhizoma acori graminei, radix polygalae, radix angelicae sinensis, fructus broussonetiae, fructus corni, semen cuscutae, fructus lycii, radix salviae miltiorrhizae, rhizoma chuanxiong, radix codonopsis, radix astragali, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae viride, digitalis, cortex fraxini, radix paeoniae alba, radix rubiae and the like. According to the external traditional Chinese medicine ointment for treating myopia and the preparation method of the external traditional Chinese medicine ointment, the raw material formula is selected, the process is simple, and the obtained external traditional Chinese medicine ointment for treating myopia can be directly applied, is convenient to use, has the effects of promoting periorbital blood circulation, relieving eye muscle spasm and eliminating eye fatigue, has a remarkable myopia treatment effect and has good economic and social benefits.

The invention provides a dual-targeting polymer drug nano-carrier, and belongs to the field of nano biomedical materials. The nano-carrier comprises a nano-material formed by a poly (lactic-co-glycolic acid)-polyethylene glycol block copolymer, and the surface of the nano-material is modified with tumor targeting functional molecules and brain targeting peptides; the tumor targeting functional molecule is folic acid, and the brain targeting peptide is connected with the nano material through a sulfydryl-maleimide group. According to the invention, biodegradable polylactic acid-glycolic acid is used as a core, tumor targeting functional molecules and brain targeting peptides are modified on the surface to obtain an Angiopep-2 / folic acid dual-targeting polymer drug nano-carrier, the barrier of BBB can be effectively overcome, meanwhile, tumor cells are targeted, and the Angiopep-2 / folic acid dual-targeting polymer drug nano-carrier can be used as a drug-loaded nano-preparation for treating brain glioma.

The invention discloses a benazepril hydrochloride-hyacinth oil nanoemulsion antihypertensive drug. Raw materials for the drug comprise, by mass percentage, 1% to 18% of benazepril hydrochloride, 15% to 40% of surfactant, 0 to 20% of cosurfactant and 1% to 20% hyacinth oil, with the balance being distilled water, wherein the sum of the mass percentage of the raw materials is 100%. Nanoemulsion provided in the invention has small and uniformly-distributed emulsion droplet particles, low viscosity and good fluidity. In the dosage form of nanoemulsion, the water-soluble drug benazepril hydrochloride and fat-soluble hyacinth oil are organically combined together, which improves the solubility and permeability of hyacinth oil and the stability and efficacy of benazepril hydrochloride. When the dosage form of nanoemulsion is prepared from benazepril hydrochloride and hyacinth oil, the advantages of both benazepril hydrochloride and hyacinth oil are combined; therefore, an antihypertensive effect of the drug provided in the invention is obviously improved, the half-life of the drug is prolonged, and administration frequency is reduced.

The invention discloses an oil-in-water type compound lomefloxacin nano-emulsion, belonging to the technical field of medicines. The nano-emulsion comprises the following components in parts by weight: 1-20 parts of herba houttuyniae aqueous extract, 5-40 parts of surfactant, 1-15 parts of co-surfactant, 1-25 parts of lomefloxacin, 1-25 parts of oil and 20-70 parts of water. The nano-emulsion disclosed by the invention is relatively narrow in latex particle size distribution, transparent in system and good in stability, has relatively low surface tension and very good fluidity, is convenient to take, and improves the solubility and penetrability of lomefloxacin to ensure that the bioavailability of a medicament is improved; and the herba houttuyniae aqueous extract is compounded with lomefloxacin, so that the antibacterial abilities of the two are mutually promoted, and the antibacterial effect is more stable.

The invention discloses a compound quercetin nano-emulsion anti-aging health care product. The raw materials and mass percentages thereof are: 1% to 15% of quercetin, 15% to 40% of a surfactant, and 1% to 10% of a cosurfactant 15%, oil 5%-25%, celery water extract 1%-15%, mushroom water extract 1%-15%, the rest is distilled water, and the mass percentage sum of the above-mentioned raw materials is 100%. The nano-emulsion emulsion has small particles, uniform distribution, low viscosity and good fluidity. The present invention uses the fat-soluble natural product quercetin with high anti-aging effect as the main component, supplemented with celery water extract and mushroom water extract, and has the functions of maintaining skin moisture, regulating sleep, delaying aging, and regulating immune function. It has a certain health care effect on diseases such as high blood pressure, high blood fat, high blood sugar, and heart disease.

The invention discloses a nano-selenium loaded VP1 gene siRNA. The nano-selenium loaded VP1 gene siRNA is small in particle size, and can avoid an immune system to reach smallest capillaries, so thatresidence time is prolonged in a bloodstream; and the nano-selenium loaded VP1 gene siRNA has the characteristics of high target selectivity and long half-life. The genetic locus interfered by the siRNA is nucleotide of the 157th; and the siRNA sequence is: Sense 5'-ggcaucaucaaaugcuagutt-3', Antisense 5'-acuagcauuugaugaugcctt-3'. The invention also provides a preparation method and an applicationof the nano-selenium loaded VP1 gene siRNA.

The invention relates to a bi-level switch electric endurance test operating mechanism, which comprises a main operating board, a compression electric cylinder, a test object clamping platform, an electric actuator and an electric sliding table. The electric actuator, the compression electric cylinder and the electric sliding table form a power output unit of the operating mechanism, a slide track is disposed on the main operating table, the test object clamping platform is disposed at one end of the main operating board, the compression electric cylinder is connected onto the test object clamping platform, the electric sliding table slides along the slide track on the main operating board, the electric actuator is connected onto the electric sliding table, and the horizontal height of the electric actuator is consistent to that of the test object clamping platform. Compared with the prior art, the bi-level switch electric endurance test operating mechanism has the advantages that investment of experimental expenses is greatly reduced, experimental cost is lowered, experimental efficiency and accuracy are improved, and the bi-level switch electric endurance test operating mechanism has a remarkable economic benefit and a remarkable social benefit.

The invention discloses a purpose of calcium sulphate crystal whiskers or a composition thereof to preparation of a skin penetration promoting agent. The calcium sulphate crystal whiskers can overcomethe stratum corneum protective screen of skin, can promote skin absorption of percutaneous absorption of medicines and cosmetic active components, and can be used for local medicine delivery or systematic medicine delivery of the skin.

The invention provides a dual-targeting polymer drug nanocarrier, which belongs to the field of nano-biomedical materials. Modified with a tumor-targeting functional molecule and a brain-targeting peptide, the tumor-targeting functional molecule is folic acid, and the brain-targeting peptide and the nanomaterial are connected through a sulfhydryl-maleimide group; the present invention is biodegradable The polylactic-glycolic acid is the core, and the Angiopep-2 / folic acid dual-targeting polymer drug nanocarrier is obtained by surface modification of tumor-targeting functional molecules and brain-targeting peptides, which can effectively overcome the BBB barrier and target tumor cells at the same time. , which can be used as a nano-formulation encapsulating drug for targeted treatment of glioma.