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Propranolol-eugenol type basil oil nano-emulsion medicament and preparation method thereof

A technology of clove basil oil and nanoemulsion, which is applied in the field of medicine, can solve the problems that propranolol and clove basil oil cannot be used, the action of propranolol is slow, and the dissolution rate of the drug is slow, so as to maintain blood drug Concentration and pharmacological effects, reducing first-pass effects, and improving bioavailability

Inactive Publication Date: 2012-09-12
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing antihypertensive drugs such as propranolol tablets on the market now, also have the use of clove basil oil, although can be absorbed from gastrointestinal tract after oral administration, but absorption is incomplete, and the stripping rate of medicine is slow in addition, and bioavailability is poor; This, combined with the slow action of propranolol, makes it impossible to take advantage of the medicinal effects of propranolol and clove basil oil

Method used

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  • Propranolol-eugenol type basil oil nano-emulsion medicament and preparation method thereof
  • Propranolol-eugenol type basil oil nano-emulsion medicament and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0061] Accurately weigh 6 g of clove basil oil, 25 g of EL40 and 5 g of ethanol and stir evenly at room temperature (25° C.), then slowly drop distilled water in which propranolol is dissolved. As the amount of distilled water increases, the viscosity of the system increases. When the amount of distilled water is added to make the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state. What is colorless and transparent propranolol, clove basil oil nanoemulsion, the amount that adds water this moment is 59g, and propranolol is 5g. This ratio is the optimal ratio of propranolol and clove basil oil nanoemulsion.

[0062] Following embodiment steps are with embodiment 1:

Embodiment 2

[0064] Clove basil oil 15g, EL40 20g, span80 10g, distilled water 54g, propranolol 1g.

Embodiment 3

[0066] Clove basil oil 10g, RH40 25g, span80 5g, distilled water 53g, 1,2-propanediol 5g, propranolol 2g.

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Abstract

The invention discloses a propranolol-eugenol type basil oil nano-emulsion medicament, which consists of the following raw materials in percentage by mass: 1-10 percent of propranolol, 10-30 percent of surfactant, 0-25 percent of cosurfactant, 1-15 percent of eugenol type basil oil and the balance of distilled water, wherein the mass percentage sum of the raw materials is 100 percent. A nano-emulsion has the characteristics of small emulsion drop particles, uniform distribution, low viscosity and high flowability. In a nano-emulsion dosage form, propranolol serving as a water-soluble medicament is organically combined with fat-soluble eugenol type basil oil, so that the dissolving and permeation capabilities of eugenol type basil oil are increased, and the stability and medicament effect of propranolol are enhanced. After the propranolol and the eugenol type basil oil are prepared into a nano-emulsion dosage form, the advantages of the propranolol and the eugenol type basil oil are combined, the hypertension resisting effect is enhanced remarkably, the half-life period of a medicament is prolonged, and the administration times are reduced.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of antihypertensive medicine propranolol and clove basil oil, in particular to a propranolol and clove basil oil nanoemulsion medicine and a preparation method thereof. Background technique [0002] Propranolol. Chemical name: 1-isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride. Its levorotatory activity is stronger than that of dextrorotatory. Its racemate is used clinically. This product is the earliest beta-receptor blocker used in clinical practice. After oral administration, it can be quickly and completely absorbed in the gastrointestinal tract, but the clearance rate in the liver is very high, and only about 30% enter the blood circulation. The drug concentration in plasma varies greatly, so there are significant individual differences in clinical dosage. It is mainly metabolized in the liver, and most of it is excreted by the kidneys. [0003] Competes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/107A61P9/12A61K31/138
Inventor 欧阳五庆孙江红欧阳伸雨
Owner NORTHWEST A & F UNIV
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