The invention provides a pharmaceutical composition for treating
senile vaginitis and a temperature-sensitive slow-release gel and preparation method thereof, and belongs to the technical field of
senile vaginitis medicine preparation. The temperature-sensitive slow-release gel of the
medicine for treating the
senile vaginitis comprises the following raw materials of nitroimidazoles,quinolones,estrogens,corticosteroids,glucose,
poloxamer,
sodium carboxymethylcellulose, moisturizing agent,
preservative,
purified water and balance pH
buffer solution, and the pH value is 3.5-4.8. The temperature-sensitive slow-release gel has the characteristics of uniform dispersion and slow release in the
vaginal canal, improves the contact area between the
medicine and the tissue, improves the
bioavailability, achieves the purpose of improving the
therapeutic effect, improves the treatment effective rate, and achieves a good
therapeutic effect; the gel also has the advantages that the gel does not flow out of the canal easily, clothes are not polluted, the
medication frequency is lower, the use is convenient, and the compliance of a patient is better.