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Pharmaceutical composition for treating senile vaginitis and temperature-sensitive slow-release gel and preparation method thereof

A vaginitis and senile technology, applied in the field of senile vaginitis drug preparation, can solve the problems of poor patient compliance and frequent administration, and achieve the effects of improving estrogen level, improving bioavailability and increasing contact area

Inactive Publication Date: 2018-10-12
THE FIRST HOSPITAL OF LANZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gel has frequent administration and poor patient compliance

Method used

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  • Pharmaceutical composition for treating senile vaginitis and temperature-sensitive slow-release gel and preparation method thereof
  • Pharmaceutical composition for treating senile vaginitis and temperature-sensitive slow-release gel and preparation method thereof
  • Pharmaceutical composition for treating senile vaginitis and temperature-sensitive slow-release gel and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0034]In the present invention, the pH buffer is sodium acetate-acetic acid buffer, which is a commonly used buffer in pharmacy; the preparation method steps of the sodium acetate-acetic acid buffer are as follows: take anhydrous sodium acetate and dissolve it in a small amount of purified water, After mixing with glacial acetic acid, add purified water and dilute to 1L to obtain sodium acetate-acetic acid buffer; the concentration of the anhydrous sodium acetate is preferably 83g / L; the concentration of the glacial acetic acid is preferably 60mL / L; the acetic acid The pH range of the sodium-acetate buffer is 3.2-6.0.

[0035] In the specific implementation process of the present invention, pH regulator can also be used to adjust the pH of the pharmaceutical composition, and the preferred pH regulator is one or more of sodium hydroxide, hydrochloric acid, boric acid, citric acid, tartaric acid and sodium acetate. kind.

[0036] In the present invention, the dosage form of the...

Embodiment 1

[0044] Embodiment 1 temperature-sensitive sustained-release gel consists of the following drugs:

[0045]

[0046] The steps of the preparation method of the temperature-sensitive sustained-release gel are as follows: firstly, disperse sodium carboxymethylcellulose in an appropriate amount of purified water, let it stand still, and after it is fully swollen, under constant stirring at 0-4°C, poloxa Add poloxamer 188 and poloxamer 407; then add the prescribed amount of medicine, humectant, and preservative in sequence, stir continuously, mix evenly, adjust the pH to 3.5-4.8, potting, and store at 0-4°C.

Embodiment 2

[0047] Embodiment 2 temperature-sensitive sustained-release gel consists of the following drugs:

[0048]

[0049]

[0050] The preparation method is the same as in Example 1.

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Abstract

The invention provides a pharmaceutical composition for treating senile vaginitis and a temperature-sensitive slow-release gel and preparation method thereof, and belongs to the technical field of senile vaginitis medicine preparation. The temperature-sensitive slow-release gel of the medicine for treating the senile vaginitis comprises the following raw materials of nitroimidazoles,quinolones,estrogens,corticosteroids,glucose,poloxamer,sodium carboxymethylcellulose, moisturizing agent, preservative, purified water and balance pH buffer solution, and the pH value is 3.5-4.8. The temperature-sensitive slow-release gel has the characteristics of uniform dispersion and slow release in the vaginal canal, improves the contact area between the medicine and the tissue, improves the bioavailability, achieves the purpose of improving the therapeutic effect, improves the treatment effective rate, and achieves a good therapeutic effect; the gel also has the advantages that the gel does not flow out of the canal easily, clothes are not polluted, the medication frequency is lower, the use is convenient, and the compliance of a patient is better.

Description

technical field [0001] The invention relates to the technical field of medicine preparation for senile vaginitis, in particular to a pharmaceutical composition for treating senile vaginitis, a temperature-sensitive sustained-release gel and a preparation method thereof. Background technique [0002] Senile vaginitis (SV) mainly occurs in postmenopausal elderly women. Due to ovarian function decline, estrogen levels decrease, and vaginal mucosa loses estrogen support and protection, vaginal wall atrophy occurs, mucosa becomes thinner, and glycogen in epithelial cells As the content of the bacteria decreases, the pH value in the vagina rises from the normal 3.8 to 4.4 to 5.0 to 7.0, which leads to a decrease in the local resistance of the vagina, and the invasion and reproduction of pathogenic bacteria cause inflammation. A small number of women have ovarian hypofunction caused by radiotherapy and chemotherapy, or senile vaginitis caused by the decrease or insufficient secreti...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/573A61K31/5383A61K31/4164A61K31/05A61K9/06A61P15/02
CPCA61K9/0034A61K9/06A61K31/05A61K31/4164A61K31/5383A61K31/573A61K45/06A61K47/10A61K47/26A61K47/38A61P15/02A61K2300/00
Inventor 张建强武新安魏玉辉王兴东张国强
Owner THE FIRST HOSPITAL OF LANZHOU UNIV
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