41results about How to "Increase upload volume" patented technology

The invention discloses a preparation method of a molecular sieve-based SCR catalyst, comprising the following steps: (1) adding Zr(NO3)4 dropwise to ammonia water under stirring conditions, adding oxalic acid to obtain a translucent zirconium oxalate sol; 2) adding aluminum isopropoxide to the zirconium oxalate sol prepared in the above step (1), adding nitric acid to adjust the pH value, heating the above mixed solution, and stirring to obtain Al2O3-ZrO2 composite sol; (3) adding deionized water and molecular sieves Mix in the composite sol prepared in the above step (2), put it into a ball mill and ball mill to obtain the coating slurry; (4) impregnate the honeycomb ceramics into the above coating slurry, take it out and blow off the remaining slurry in the channel, The impregnation and drying were repeated three times, and finally the catalyst was calcined to obtain the monolithic selective reduction (SCR) catalyst. The selective reduction (SCR) catalyst prepared by the invention has high loading capacity, uniform coating and low shedding rate.

The invention discloses a double-oxidization catalyst for purifying diesel engine exhaust and a preparation method thereof. The double-oxidization catalyst comprises a front-stage carrier and a rear-stage carrier which are orderly arranged along the axial direction of an engine exhaust port, wherein the front-stage carrier is arranged near the engine exhaust port; the rear-stage carrier is arranged far away from the engine exhaust port; a front-stage coating is coated on the front-stage carrier; a rear-stage coating is coated on the rear-stage carrier; slurries for preparing the front-stage coating and the rear-stage coating respectively contain deionized water, rare-earth complex oxide, modified aluminum oxide, a binder and active ingredients; and at least one of the two slurries for preparing the front-stage coating and the rear-stage coating also contains silica-alumina composite oxide. By adopting the double-oxidization catalyst for purifying the diesel engine exhaust and the preparation method thereof, the loading amount of the active coating is effectively increased; dropping of the coatings is overcome; the coatings are even and have significant catalytic activity; and purification of the diesel engine exhaust can be effectively achieved.

The invention relates to the field of synthesis of medicinal chemistry, and particularly relates to a preparation method of a targeted amphiphilic small molecular prodrug for pH response and collaborative treatment, which is a preparation method and application of an adriamycin-based amphiphilic small molecular prodrug for acid response. The preparation method of the amphiphilic small molecular prodrug comprises the following steps of (1) carrying out hydrophilic drug molecule methotrexate (MTX)-based chemical modification, introducing a tert-butyl oxygen carbonyl-protected pH responsive hydrazine bond to a hydroxyl part with low steric hindrance in methotrexate; and (2) introducing an adriamycin (DOX) hydrophobic drug molecule after hydrazide tert-butyl carbonyl protection and obtaining the amphiphilic small molecular prodrug for pH response. The obtained amphiphilic small molecular prodrug can be self-assembled into a drug nano-micelle, the drug can be selectively released, and the amphiphilic small molecular prodrug has the advantages of targeted delivery, high drug loading capacity, stimulus-response-controlled drug release and high micelle stability. The problems of the water solubility of the hydrophobic drug molecule and combined nanodrug delivery can be effectively solved.

The invention relates to a heparinized bacterial nanocellulose / chitosan composite tube and a preparation method and application thereof. The heparinized bacterial nanocellulose / chitosan composite tube has a 3D fiber network structure; chitosan is deposited on the surface of a nanofiber and in a network; and heparin is grafted on bacterial nanocellulose and the chitosan. The preparation method comprises the steps of putting the pretreated bacterial nanocellulose BNC into a chitosan CH acid solution for oscillation, immersing the bacterial nanocellulose BNC into an alkaline solution for standing and cleaning to obtain the BNC / CH composite tube; and putting the BNC / CH composite tube into a buffer solution for oscillation and putting the composite tube into a heparin Hep cross-linking system for oscillating and cleaning to obtain a BNC / CH-Hep composite tube. The mechanical property is strengthened, the heparinized bacterial nanocellulose / chitosan composite tube has a better anticoagulation effect, thrombosis is prevented, adhesion, multiplication and growth of cells are facilitated, and meanwhile, the chitosan is capable of achieving slow release of the heparin through degradation in a body and maintaining higher vascular patency rate, and has great potential in application in the field of tissue engineering, such as an artificial blood vessel, an artificial trachea, a nerve conduit and a catheter.

The invention relates to the fields of chemical synthesis and biological representation, and more particularly, provides a preparation method and an application of a pH-responsive amphiphilic rod-likepolymer prodrug, which is represented as the drawing in the specification. The preparation method of the amphiphilic rod-like polymer material includes the following steps: 1) synthesizing a rod-likeATRP initiator on the basis of glucan; 2) introducing a pH-responsive hydrophobic block on the basis of ATRP reaction; 3) introducing a hydrophilic block on the basis of ATRP reaction to obtain an amphiphilic polymer material; 4) substituting an ester group on the terminal of MGMA by means of hydrazine hydrate, thus producing a pH-responsive precursor; 5) forming a hydrazone bond by means of a carbonyl group on adriamycin and an amino group on the polymer material, thus producing the pH-responsive polymer prodrug. By means of weak acidity of interior of cancer cells, the amphiphilic rod-likepolymer prodrug can selectively release a drug by means of pH-stimulating response. The polymer prodrug is high in micelle stability, is high in drug carrying capacity and enables drug release to be under stimulating response control.

The invention specifically relates to a tadalafil supramolecular nanoparticle and a preparation method and application thereof. The specific preparation methods include: (1) using Fe 3+ It binds with the phototherapy drug indocyanine green ICG through coordination interaction; (2) the immunosuppressant tadalafil TAD binds with ICG / Fe 3+ Self-assembly of Fe by π-π stacking interactions between benzene rings 3+ / ICG@TAD nanoparticles. The preparation method is simple and feasible, the obtained nanoparticles have high micellar stability, high drug loading, and under the GSH reduction conditions with high tumor microenvironment, Fe 3+ When reduced, the nanoparticles are decomposed, which in turn selectively releases the drug. This strategy effectively solves the disadvantages of hydrophobic drug molecules in drug delivery systems, such as poor water solubility and large toxic and side effects. The synergistic effect of immunosuppressive drugs and phototherapy drugs shows enhanced tumor suppressive ability and has broad application prospects in synergistic immunotherapy.

The invention discloses a preparation method of an organic ligand modified formaldehyde purification catalyst. La accounting for 1%-10% of titanium oxide by weight is premixed with at least one of Cu, Fe and Ni and at least one of Sn and Mn and then mixed with water, water-soluble salt is prepared, titanium oxide powder is added, the mixture is dried and calcined at a high temperature, a modified catalyst carrier is prepared and added to a Pt organic solution, the mixture is dried and calcined at a high temperature, modified catalyst carrier powder is prepared and mixed with pseudo-boehmite, methylcellulose and water, modified paste is prepared, honeycomb ceramic plates are dipped in the modified paste, then dried, calcined, cooled and reduced, and the organic ligand modified formaldehyde purification catalyst is obtained. The catalyst can filter dust, eliminate peculiar smells, perform sterilization and disinfection functions and adsorb harmful gas and can also promote complete catalytic decomposition of harmful gas, so that the adsorbed harmful gas cannot cause secondary pollution, a catalyst layer is not prone to peel or crack, and the service life is long.

The invention discloses a large-scale synthesis method of argireline. The preparation method comprises the following steps: by taking 2 Chlorotrityl Chloride Resin as a carrier, carrying out solid-phase synthesis to obtain fully-protected fragment peptidic acid, carrying out a liquid-phase amidation reaction on a carboxyl terminal by taking the fully-protected peptidic acid fragment as a raw material to obtain fully-protected amide, and carrying out deprotection to obtain the target peptide. Compared with amino resin commonly used in an existing synthesis method, the selected resin carrier islow in price, and the uploading amount is increased by nearly one time; a selected ammonia reagent for the an amidation reaction is cheap, easy to obtain and short in amidation reaction time, and hydrolysis of ester is inhibited.In the cutting post-treatment process, anhydrous ether is abandoned, so that the safety is high, and the method is environment-friendly. The method overcomes the problemsof high cost and low loading capacity of the existing classic solid-phase synthetic resin, also overcomes the defects of complex liquid-phase synthesis process, long synthesis period and low efficiency, has the advantages of low synthesis cost, high synthesis efficiency and simple synthesis method, and can be used for large-scale synthesis of the argireline.