The invention provides a safety application device for computer informatization, which includes a computer mainframe, a heat dissipation base, a cooling liquid coil, a waterproof inner layer, a circulating water pump, a heat dissipation fan, an inner mesh surface, an outer mesh surface, an adsorption mesh surface, an installation layer and Multiple pieces of semiconductor cooling chips; the waterproof inner layer is set on the inner wall of the heat dissipation base, and the computer host sits in the heat dissipation base and is in contact with the waterproof inner layer; the refrigerant coil is placed in the heat dissipation base, and the circulating water pump is set on the rear end surface of the heat dissipation base The upper part is connected with the refrigerant coil; the cooling fan is set in the main computer, the inner net cover is covered on the cooling fan, the installation layer is set on the outer end surface of the inner net surface, and multiple semiconductor cooling chips are installed in the installation layer; the adsorption net The surface is arranged on the outer end surface of the installation layer, and the outer mesh surface is arranged on the outer end surface of the adsorption mesh surface. The invention can dissipate heat, cool the air, prevent dust and prevent moisture for the computer mainframe, which is beneficial to the long-term continuous and high-efficiency operation of the computer mainframe and ensures the safe application of the computer.