The invention discloses a preparation method of 8-amidoquinoline derivatives (compound II) and dihalohydantoin (compound III) at a certain reaction temperature. ) as a raw material, in the presence of a phase transfer catalyst, stirred and reacted for a certain period of time in a reaction solvent; R 1 It is one of C1~C6 alkyl, cycloalkyl and aromatic groups, R 2 or R 3 is H, F, Cl, Br, CH 3 、CF 3 , OCH 3 , NO 2 , one of CN; after the reaction is finished, the 8-amide-5-halogenated quinoline derivative (compound I) is obtained through aftertreatment. The method of the present invention has the characteristics of environmental protection, atom economy, high yield, simple operation, no need to use metals, easy amplification, etc., promotes the development of halogenated quinoline derivatives, and provides a powerful tool for the development of halogenated quinoline derivatives drugs protection.