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Method for synthesizing pyrazole heterocycle without catalyst or solvent

A pyrazole heterocycle, solvent-free technology, applied in the synthesis field of pyrazole heterocycle, can solve problems such as catalyst dependence, and achieve the effects of simple operation, mild conditions and high yield

Inactive Publication Date: 2010-12-01
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage of this type of method is: there is a dependence on the catalyst

Method used

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  • Method for synthesizing pyrazole heterocycle without catalyst or solvent
  • Method for synthesizing pyrazole heterocycle without catalyst or solvent
  • Method for synthesizing pyrazole heterocycle without catalyst or solvent

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Abstract

The invention relates to a method for synthesizing pyrromonazole heterocycle, aiming at providing a synthetic method which causes dicarbonyl compound and hydrazine compound to condense to obtain the pyrromonazole heterocycle under the condition of having no catalyst and no solvent. The method includes the steps: the dicarbonyl compound and the hydrazine compound are mixed together and stirred forreaction at the temperature of 0-100 DEG C; after the reaction, the mixture product is separated by column chromatography, and the pure product of pyrromonazole heterocycle is obtained. The product prepared by the invention is a type of important bioactivator and plays very important role in the synthesis and application of the medicine; the synthetic method has mild conditions, better stereoselectivity of the products, and higher productive rate; as no catalyst and no solvent are available in the course of reaction, the method is economical and environment-friendly; the reaction materials are easy to obtain and operate, thereby being suitable for laboratory preparation and industrial scale production.

Description

Catalyst-free and solvent-free synthesis of pyrazole heterocyclic rings technical field The invention relates to a synthesis method of a pyrazole heterocycle, in particular to a synthesis method for obtaining a pyrazole heterocycle by condensing a dicarbonyl compound and a hydrazine compound under the condition of no catalyst and solvent. Background technique Most of the existing methods for preparing pyrazole heterocycles are: condensing dicarbonyl compounds and hydrazine compounds under Lewis acid catalysis to obtain pyrazole heterocycles (Tetrahedron Letters 2008, 49, 397-400). The defect of this type of method is: there is dependence on the catalyst. Contents of the invention The object of the present invention is to overcome the deficiencies in the prior art and provide a synthesis method for condensing dicarbonyl compounds and hydrazine compounds to obtain pyrazole heterocycles under the condition of no catalyst and no solvent. In order to solve the above techni...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D231/12
Inventor 陈香佘进商志才吴军张培志
Owner ZHEJIANG UNIV
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