101 results about "Triphenyl phosphonium" patented technology

The invention relates to a synthetic method of cholesterol. The synthetic method of the cholesterol specifically comprises the following steps that 1, firstly, triphenylphosphine and 1-chlorine-4-methylpentane are used to react to obtain a 4-methyl pentyl triphenyl phosphonium chloride solution, then potassium tert-butoxide or sodium tert-butoxide is added to react to obtain a witting reagent, a witting reaction occurs by adding pregnenolone into the witting regent, and a compound 03 is obtained through extracting after complete reaction; 2, under the action of chirality phosphine ligand and a rhodium catalyst, an asymmetric hydrogenation reaction occurs to the compound to obtain the cholesterol. According to the synthetic method of the cholesterol, a 6-step reaction of an existing method is simplified into a 2-step reaction, and meanwhile the ring-opening reaction consuming a large amount of hydrochloric acid and zinc powder is omitted. The technology is simple, the consumption of raw materials is less, the yield is high, the cost is low, environmental protection is achieved, so that the economical effect and the environmental protection are achieved, and the industrial implementation is facilitated.

The invention discloses a quaternary phosphonium salt as well as a preparation method and application thereof. The quaternary phosphonium salt is allyl triphenyl phosphonium bromide and has a structural formula I shown in the specification. The preparation method of the quaternary phosphonium salt comprises the following steps of: (1) adding alkenyl halide and trialkyl phosphine which have the mole ratio of 1.13-1.5:1.0 to a solvent, heating to 55-75 DEG C, and reacting for 7-12 hours so as to prepare a crude quaternary phosphonium salt product, wherein reactants need to be continuously stirred in the process; (2) after the crude quaternary phosphonium salt product is cooled to 20-30 DEG C, gathering the crude quaternary phosphonium salt product through a filtering method, and washing and purifying by using the solvent so as to obtain the quaternary phosphonium salt. The preparation method of the quaternary phosphonium salt has the advantages of simpleness, few steps, short time and high product yield; the obtained quaternary phosphonium salt has unsaturated structure, can be used for preparing novel materials by grafting with high-molecular materials, i.e. plastics, rubbers, and the like, can also be used as an antibacterial agent and a surface active agent and has wide application scope; and in addition, the invention increases the variety of the traditional antibacterial agent.

The invention discloses TPP mitochondria target astaxanthin emulsion. The TPP mitochondria target astaxanthin emulsion comprises components of 0.5-1mg / mL of casein, 0.1-0.2mL / mL of medium chain triglyceride, 0.02-0.04mL / mL of dimethyl sulfoxide, 0.025-0.05mg / mL of triphenyl phosphonium bromide, 0.025-0.05mg / mL of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), 0.01-0.025mg / mL of N-hydroxysuccinimide, 0.05-0.1mg / mL of astaxanthin, and the balance water. During preparation of the emulsion, casein is used for entrapping astaxanthin, and the surface of the emulsion is subjected to triphenyl phosphonium bromide modification, so that the emulsion can be distributed in the mitochondria in a targeted manner. Nutrient entrapping is realized, besides, nutrients are in targeted positioning, the bioactivity is developed, and interfering and destroying of bioactivity by external environment are avoided.

The invention relates to a mitochondrion-targeted micelle material which is formed by bonding one hydroxyl on a hyaluronate oligomer with 5-carboxyl of (5-carboxylamyl)-triphenyl phosphonium bromide through an ester bond. The general formula is disclosed in the specification, wherein n is a positive integer, and the molecular weight of the hyaluronate oligomer is less than 10000 Da. The invention also relates to a preparation method of the mitochondrion-targeted micelle material, and a curcumin micelle preparation prepared from the micelle material and a preparation method thereof. The micelle material has tumor and mitochondrion targeting properties; and the curcumin micelle preparation prepared from the micelle material can precisely guide the curcumin into the tumor cells and mitochondrions thereof, thereby better displaying the antitumor function.

This invention relates to a method for synthesizing an anti-tumor compound CA4. The method comprises: dissolving substituted benzyl triphenyl phosphonium halide and substituted aromatic aldehyde in a solvent, heating under the effect of alkali to synthesize hydroxyl-substituted diphenyl ethylene compound, removing the solvent, acidifying, extracting with an organic solvent, washing the organic phase with saturated sodium hydrogen sulfite solution, washing with water, drying, and performing silica gel column chromatography to obtain a mixture of cis-CA4 and trans-CA4. The method has such advantages as simple process and mild reaction conditions (no need for low-temperature and anhydrous conditions).

The invention relates to a fluorescent probe for detecting CysSnSSH (n is larger than one), in particular to a BODIPY derivative for measuring the CysSnSSH and application thereof. The BODIPY derivative is shown in the general formula I. In the general formula I, R1 (a detection group) is a sulfydryl benzoyl group or an aryl selenol benzoyl group or a tellurium phenol benzoyl group; R2 (a positioning functional group) is a sulfydryl benzoyl group, an aryl selenol benzoyl group, a tellurium phenol benzoyl group, a butyl triphenyl phosphonium group, an N-propyl morpholino group, a biotin group, a folic acid group, a glycosyl chain group or a C1-25 alkyl group; X represents H or halogen; Y represents N or C; Z represents N or O. In the presence of CysSnSSH, corresponding fluorescence intensity changes, and the compound like the CysSnSSH fluorescent probe can be used for detecting CysSnSSH, interference of external detection conditions can be greatly reduced, the sample treatment time is saved, and the detection precision is improved.