The invention belongs to the technical field of ceramics, and relates to an antibacterial sanitary ceramic glaze and a preparation method. The antibacterial sanitary ceramic glaze is prepared from the following raw materials: potash feldspar, sandstone, dolomite, limestone, zircon powder, frit, aluminum oxide, zinc oxide, Suzhou clay, zirconium iron pink, praseodymium yellow, cellulose and compound antibacterial powder; the composite antibacterial powder is prepared from the following raw materials in percentage by mass: 15 to 20 percent of silver molybdate, 60 to 65 percent of zinc molybdate and 20 to 25 percent of titanium dioxide. The preparation method of the antibacterial sanitary ceramic glaze comprises the following steps of A, preparation of the composite antibacterial powder; B, preparation of glaze slip; C, preparation of the antibacterial sanitary ceramic glaze. The preparation method provided by the invention is simple and is easy to operate; the antibacterial sanitary ceramic glaze is resistant to a high temperature, does not discolor, and is excellent in antibacterial property.