44 results about "Psychotropic drug" patented technology

Neural networks are constructed (programmed), trained on historical data, and used to predict any of (1) optimal patient dosage of a single drug, (2) optimal patient dosage of one drug in respect of the patient's concurrent usage of another drug, (3a) optimal patient drug dosage in respect of diverse patient characteristics, (3b) sensitivity of recommended patient drug dosage to the patient characteristics, (4a) expected outcome versus patient drug dosage, (4b) sensitivity of the expected outcome to variant drug dosage(s), (5) expected outcome(s) from drug dosage(s) other than the projected optimal dosage. Both human and economic costs of both optimal and sub-optimal drug therapies may be extrapolated from the exercise of various optimized and trained neural networks. Heretofore little recognized sensitivities-such as, for example, patient race in the administration of psychotropic drugs-are made manifest. Individual prescribing physicians employing deviant patterns of drug therapy may be recognized. Although not intended to prescribe drugs, nor even to set prescription drug dosage, the neural networks are very sophisticated and authoritative "helps" to physicians, and to physician reviewers, in answering "what if" questions.

The present invention provides methods and systems or apparatuses, to analyze multiple molecular and clinical variables from an individual diagnosed with a psychiatric disorder, such as post-traumatic stress disorder (PTSD), in order to optimize medication selection for therapeutic response. Molecular co-variables include polymorphisms in genes including those involved in central control and mediation of the hypothalamic-pituitary axis (HPA) stress response, the density of methylation in regulatory regions of said polymorphic genes, polymorphisms in genes that encode cytochrome P450 enzymes responsible for drug metabolism, and drug-drug and drug-gene interactions. Clinical co-variables include but are not limited to the sex, age and ethnicity of that individual, medication history, family history, diagnostic codes, Pittsburgh insomnia rating score, and Charlson index score. The system makes a determination based on unstructured and structured data types derived from internal and external knowledge resources to determine psychotropic drug choice that best matches the molecular and clinical variation profile of an individual patient. The decision support system provides a therapeutic recommendation for a clinician based on the patient's variation profile.

Novel compounds of structural formula (I) are antagonists and / or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as, the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

The invention discloses a method and kit for simultaneously measuring 35 kinds of psychotropic drugs by liquid chromatography-mass spectrometry. By optimizing chromatographic conditions and mass spectrometry conditions, the 35 kinds of psychotropic drugs can be simultaneously treated, the pretreatment step of the psychotropic drugs is simple, and protein precipitation is conducted simply through methanol. Compared with the prior art, the kit and the corresponding detection method have the advantages that the cost is greatly reduced, the analysis time is greatly shortened, the sensitivity is improved, the flux is increased, and the needs for clinical detection are met.

Conjugates of a gamma-aminobutyric acid (GABA) compound or a glycine compound and an analgesic drug are disclosed. Further disclosed are pharmaceutical compositions containing these conjugates and uses thereof in the treatment of CNS-associated diseases or disorders, optionally in combination with a psychotropic drug.

The invention discloses a primer group, a kit and a method for detecting polymorphic sites of psychotropic drug related genes and relates to the technical field of gene polymorphism detection. The primer group comprises one or more of combinations 1-25. The primer group can be used for detecting the polymorphism of 25 SNP sites of 20 psychotropic drug related genes simultaneously and has the characteristics that the cost is low, result interpretation is simple, interference among SNP sites is avoided and the like.

The invention discloses a cigarette for detoxification, wherein, tobacco shreds are composed of tobacco and lotus leaves absorbing ingredients of a detoxification drug, and the tobacco accounts for 10 to 50 percent of the total mass of the tobacco shreds. The invention further discloses a preparation method of the cigarette for detoxification. The cigarette for detoxification of the invention can allow drug aerosol to be absorbed by the human inner mucosa in the ionic state with the help of a smoking mode of the cigarette by the people, thus having significant efficacy, rapid effectiveness and facilitating the fine adjustment and control of the dose of the psychotropic drug; furthermore, the preparation method is simple and easy to realize, thus having broad market prospect.

The invention discloses an intelligent drug cabinet based on RFID (Radio Frequency Identification Devices) and an RFID reading method of the drug cabinet. The intelligent drug cabinet comprises a cabinet body 1, a plurality of drug storage drawers 2, a main control module 3, an RFID collection terminal 4, a temperature and humidity collection terminal 5, a communication module 6, an electromagnetic lock module 7 and a mechanical lock 8. The invention also provides a method for reading protocol of an intelligent drug cabinet tube through RFID. With adoption of a manner of reading labels by using stepped radio frequency power, the reliability of identifying labels in the intelligent RFID drug cabinet is improved and the negative impact brought by multi-path effect and label angles is emphatically avoided, so that the drugs stored in the drug cabinet are managed intelligently, the supervision and management of special drugs such as toxicant drugs, anesthetic drugs, psychotropic drugs and radioactive drugs are improved, and the working efficiency of drug management is improved.

The invention discloses a synthesis method of a sulfonamide compound represented in a formula (2). According to the method, diazonium salt is used as a reaction raw material, and under the action of an inorganic nitrogen reagent, an inorganic sulfur dioxide reagent, an additive and a phosphine reagent, the diazonium salt is reacted in a solvent at 60-100 DEG C to obtain various sulfonamide compounds. According to the method inorganic salt is used as a nitrogen atom source and a sulfur dioxide source under a metal-free catalytic condition to construct the sulfonamide compound through one step,thereby avoiding the conventional multi-step synthesis of sulfonamide by condensing unstable acid chloride and amine; and the developed sulfonamide synthesis method can be further applied to the synthesis of the arthritis drug celecoxib and the psychotropic drug sulpiride.

The invention provides toxic drug, narcotic drug and psychotropic drug storage equipment which comprises a storage frame, a controller and a scanning device. A plurality of storage boxes for storing drugs are arranged in the storage frame; the controller is arranged on the storage frame; the scanning device is electrically connected with the controller, and is used for scanning prescription information and sending the prescription information to the controller; and each storage box is provided with a driving assembly which is electrically connected with the controller, and after the controllerreceives the prescription information, the controller controls the driving assembly of the storage box storing the drugs corresponding to the prescription information to drive the storage box to open. The invention further provides a toxic drug, narcotic drug and psychotropic drug management method. According to the technical scheme, drugs are stored in the storage boxes on the storage frame in advance, and when the scanning device scans the prescription information, the controller controls the storage box stored with the drugs matched with the prescription information to be opened accordingto the drugs recorded on the prescription information. Therefore, medical staff can take and receive medicine conveniently, and the working efficiency of the medical staff is improved.

The invention relates to a sustained-release injection preparation and its preparation method and application. Specifically, the present invention relates to a sustained-release injection preparation, which includes psychotropic drugs and a non-aqueous carrier, and the preparation can be sustained-release for at least one week. The sustained-release injection preparation has better sustained-release effect, longer effect, more stability, simple dosage form, no freeze-drying, simpler preparation process, lower cost and more convenient use.

The invention provides a method for simultaneously detecting mental disease drugs and metabolites thereof in human blood or hair by adopting an ultra-high performance liquid chromatography ultravioletdetection method. Chromatographic conditions are as follows: (1) a chromatographic column which adopts a C18 chromatographic column; (2) a mobile phase comprising a phase A which is a 0.05 v / v% formic acid aqueous solution, and a phase B which is a 0.05 v / v% formic acid-methanol solution; and (3) a detector which is an ultraviolet detector; Separation and analysis of common mental disease drugs and metabolites thereof are realized through a gradient elution program. The separation and analysis method adopted by the invention is simple, does not use expensive mass spectrum, and has significantacademic significance and economic value for guiding clinical medication and analyzing samples.

The invention relates to a traditional Chinese medicine pill for curing amenorrhea resulted from psychotropic drugs and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following bulk drugs in parts by weight: 80-100 parts of salvia miltiorrhiza bunge, 80-100 parts of peach kernel, 80-100 parts of safflower, 30-40 parts of cinnamon, 30-40 parts of fennel, 40-60 parts of folium artemisiae argyi, 40-60 parts of rhizoma cyperi, 40-60 parts of radix linderae, 40-60 parts of angelica sinensis, 40-60 parts of szechuan lovage rhizome, 40-60 parts of twotooth achyranthes root, 40-50 parts of rhizoma corydalis, 40-60 parts of bighead atractylodes rhizome and 40-60 parts of poria. The preparation method is as follows: weighting and processing 900g of the bulk drugs in parts by weight; taking 600g of the processed bulk drugs, adding 1200ml of water in the 600g of the processed bulk drugs, decocting for 40 minutes, removing dregs, decocting once again until the decoction liquid boils, decocting by slow fire and concentrating until the volume of the decoction solution is 400ml for later use; and grinding the rest 300g of the bulk drugs into fine powder, and placing the fine powder in a pelleting container, spraying the concentrated liquid in the pelleting container to prepare into water pills, taking the water pills out of the container and drying to obtain the concentrated pills. The traditional Chinese medicine pill is a pure traditional Chinese medicine preparation, has no toxic or side effect, is convenient to take and has low price.

The invention discloses a method for synchronously detecting multiple psychotropic drugs in a water body, and belongs to the technical field of novel pollutant enrichment detection in the water body.The method comprises the following steps of: (1) water sample pretreatment: filtering to remove suspended particulate matters in water, and adding an internal standard; (2) solid phase extraction: enriching and extracting a target compound in the water sample through an HLB solid phase extraction column; (3) blowing the collected eluted liquid nitrogen to near dryness; (4) qualitatively and quantitatively detecting the target compound by using the UPLC-MS / MS. The synchronous detection method disclosed by the invention can simultaneously detect the psychotropic drugs in the water body 16, and the method has the advantages of high accuracy, high sensitivity, and low detection limit.

The invention is generally directed to a physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs. In one embodiment, the invention relates to the use of genetic variants of marker genes to predict the likelihood that an individual will experience undesirable metabolic side effects as a result of the use of a drug including, but not limited to, psychotropic drugs. The invention also relates to methods predicting the likelihood of diabetes and metabolic syndromes induced by the use of drugs with undesirable metabolic side effects.

The invention discloses a method of degrading and removing anti-depression psychotropic drugs in water by ionizing radiation. The method removes, by mineralization, the anti-depression drug citalopram, which contains a free radical remover and active group accelerant H2O2, through the redox action between citalopram and high-reaction-activity H OH and eaq-secondary particles generated by electronbeam bombardment of a solution; the method is a simple universal advanced oxidization method, having the advantages of high efficiency, zero initiator, no need for experimental condition control, lowenergy consumption and low cost; the method is efficient in treating wastewater containing the anti-depression psychotropic drug citalopram, with short treatment cycle, complete degradation, mild reaction conditions, zero secondary pollution and significant comprehensive economic benefit; the method is particularly applicable to efficient quick removal of trace organic pharmaceutical active compounds and other emerging pollutants; the method has a promising development and application prospect in wastewater treatment and ecological environment protection.

The present invention comprises methods and pharmaceutical compositions for intranasal delivery of effective amounts of DFO directly to the CNS, in particular the brain treatments that inhibit GSK3b in patients with psychiatric disorders including, but not limited to, bipolar disorder, depression, ADHD and schizophrenia. In addition a treatment composition is disclosed which comprises DFO and in certain embodiments combines DFO with one or more of the psychotropic drug types, i.e., antipsychotics, mood stabilizers and antidepressants. Moreover, a treatment for treating impairment of neural plasticity through inhibition of GSK3b is provided as well as prevention of apoptosis of cells through inhibition of GSK3b.

The invention relates to the technical field of clinical blood concentration monitoring of psychotropic drugs, in particular to an HPLC-DAD method for determinating quetiapine drug concentration of human serum. The invention provides a method for determinating the quetiapine concentration of the serum after a quetiapine drug is taken. The method comprises the following steps: pretreating a human serum sample and performing high-performance liquid chromatography (HPLC-DAD) analysis. The invention establishes the HPLC-DAD method with strong specificity, high sensitivity and high reproducibility.By the method for determinating the quetiapine blood concentration, established for the first time, verification results in aspects of accuracy, precision, specificity, stability and the like meet analytical requirements of the 2015 edition of relevant guiding principles of the Pharmacopoeia of the People's Republic of China (9012) on a biological sample.

The invention provides a method for simultaneously and quantitatively detecting psychotropic drugs or metabolites thereof in a biological sample by adopting a UPLC-UV detection method. The method comprises the following steps: S1, chromatographic conditions; S2, working solution preparation; and S3, a determination method. The retention time tR and peak area integral of the standard substance and the test substance of the mental drug and the metabolite thereof are respectively obtained, a standard curve is established for the concentration of the mixed standard substance solution and the corresponding peak area / internal standard area ratio, and then the concentration of the test substance solution is obtained according to the peak area integral of the test substance solution and the standard curve. The invention also discloses a detection kit prepared by the method. According to the present invention, the separation of the common psychiatric drugs in the biological sample is achieved by using the UPLC-UV method, and the kit is prepared from the common psychiatric drugs, such that the in-vivo concentration of the common clinical psychiatric drugs can be rapidly, simply, accurately and quantitatively detected, and the good academic and commercial values are provided.

The invention relates to an artificial intelligence narcotic and psychotropic drug storage system, which belongs to the field of medical equipment. The system mainly comprises a narcotic and psychotropic drug storage system main body part, a display screen, a high-definition camera module, a core board, an identity acquisition module, an identity recognition module and a loudspeaker with a function of converting characters into voice, and further comprises an application program of operation software developed for the artificial intelligence narcotic and psychotropic drug storage system and anHIS interface connected with a hospital information system. By using face image recognition and fingerprint recognition, the identity of an operator can be truly identified, the use safety and the efficiency of toxic, numb and mental drugs are improved, and the function of tracing related medical accidents can be achieved. In addition, compared with the traditional character prompts, a friendlierhuman-computer interaction interface and voice prompts are further provided.

The invention discloses a poisonous, anaesthetic and psychotropic drug management platform. The platform comprises a department management platform, a hospital management platform and a regional management platform; the department management platform is used for managing poisonous, anaesthetic and psychotropic drug data taking a department as a unit, wherein the poisonous, anaesthetic and psychotropic drug data comprises poisonous, anaesthetic and psychotropic drug use data, drug inventory data and empty drug bottle recovery data; the hospital management platform is used for integrating the poisonous, anaesthetic and psychotropic drug data saved by all hospitals and saving the integrated poisonous, anaesthetic and psychotropic drug data. The invention also discloses a poisonous, anaesthetic and psychotropic drug management device and a computer readable storage medium. According to the established drug management platform, instant data of drug use, drug inventory and empty drug bottlerecovery is collected by taking the department as the unit, and then according to the regional management platform, drug use and empty drug bottle recovery data collected in all hospitals in the region is integrated for data storage and management work, so that all related data in the large region is integrated through collection and management of the poisonous, anaesthetic and psychotropic drug data of the source, thereby achieving the advantage of integrated poisonous, anaesthetic and psychotropic drug management.

The invention discloses and develops a withdrawal Chinese herbal medicine, made mainly from, ginseng root, licorice root, Herba Polygalae cum Radice, Fructus Alpiniae Oxyphyllae, Fructus Schisandrae Chinensis, Semen Nelumbinis, Fructus Tritici Levis, Semen Myristicae, Rhizoma Zingiberis, Rhizoma et Radix Nardostachydis, Herba Taraxaci, Rhizoma Phragmitis, Poria, Semen Ziziphi Spinosae, Cortex Albiziae, Rhizoma Corydalis, Semen Persicae, Flos Carthami, Ramulus Uncariae cum Uncis, and Rhizoma Gastrodiae. Accordingly, the inventor also develops a teabag (Ren Cao intelligence tea) made with the Chinese herbal medicine; since the common Chinese herbal materials are used herein and are suitable in taste and moderate in price, the Chinese herbal medicine has sweet aftertaste and fluid-promoting function when acting as substitute tea for brewing or decocting, is free of bitter taste in common herbal decoctions, is convenient for individuals to use in families or communities for voluntary withdrawal and rehabilitation, and is a special tea drink suitable for most patients with drug trouble; practical uses show that the Chinese herbal medicine can eliminate withdrawal symptoms on a withdrawal subject, is suitable for the withdrawal of psychotropic drug addicts, and is an ideal substitute for withdrawal.

The invention discloses a gene polymorphism detection kit for guiding psychiatric medication. The kit comprises a specific primer group and a fluorescent probe group, wherein the specific primer group and the fluorescent probe group are used for detecting the rs1065852 site of a CYP2D6 gene, the rs1414334 site of an HTR2C gene, the rs1800497 site of an ANKK1 gene, the rs762551 site of a CYP1A2 gene, the rs489693 site of an MC4R gene and the rs1799978 site of a DRD2 gene. According to the invention, the primer group and the fluorescent probe group are utilized, and the template DNA is specifically amplified by using a fluorescent PCR amplification technology, so that the polymorphism of a plurality of sites of a plurality of genes related to psychotropic drugs can be accurately detected at the same time; ARMS primer design is adopted, mismatched bases are introduced, the specificity of primer amplification is improved, the sensitivity is high, and accurate genotyping can be conducted on human template DNA at the lowest DNA initial amount of 10 ng; the detection speed is high and the efficiency is high: the PCR reaction only needs less than 1 hour to complete the amplification reaction, the cost is lower, the required reagent consumables are all clinically common reagents, the cost is lower, and the clinical popularization is convenient.

The invention discloses a method and kit for simultaneous determination of 35 kinds of psychotropic drugs by high performance liquid mass spectrometry. The simultaneous processing of 35 kinds of psychotropic drugs is realized by optimizing the chromatographic conditions and mass spectrometry conditions, and the pretreatment steps of psychotropic drugs are simple. Methanol is used for protein precipitation. Compared with the existing technology, the kit and the corresponding detection method greatly reduce the cost, greatly shorten the analysis time, improve the sensitivity and throughput, and meet the needs of clinical detection.

The invention relates to an intelligent drawer device for narcotic and psychotropic drugs in an operation room. The intelligent drawer device comprises a box body and a recovery box arranged on one side of the box body; the box body is provided with a plurality of intelligent drawers along the vertical direction; electromagnetic locks are arranged on the box body; magnetic absorption blocks magnetically attracted with the electromagnetic locks are respectively arranged on the intelligent drawers; a layer display indicator is arranged on each intelligent drawer; panels and a handle are arrangedon each intelligent drawer; a plurality of intelligent medicine boxes are arranged in each intelligent drawer; an openable cover plate is arranged on each intelligent medicine box; a medicine box display is arranged on each intelligent medicine box; a touch button is arranged on each intelligent medicine box; a display screen is arranged on the box body; a card reader is arranged on the surface of the box body; an electronic tag identification module and an electronic tag writing module are integrated in the card reader; and universal wheels which are convenient for movement are arranged at the bottom of the box body. According to the invention, storing and taking of medicines are recorded, a nurse can take the medicines more conveniently, error probability is reduced, and tracing of themedicines is more convenient.

The invention relates to the technical field of immunodiagnosis, discloses a preparation method of a to-be-detected liquid of psychotropic drugs in hair aiming at the problem of long cracking period of the to-be-detected liquid of psychotropic drugs in hair in the prior art, and the method comprises the following steps: (1) hair cleaning: alternately cleaning hair by using a functional protein-based surfactant and pure water; (2) hair softening: adding the cleaned hair into a softening solution for soaking and softening treatment to obtain a softened product; (3) hair cracking: adding crackingpowder into the softened product obtained in the step (2), adding a grinding aid at the same time, and grinding and cracking to obtain a pyrolysis product; and (4) drug micromolecule preservation: adding a preservation solution into the pyrolysis product obtained in the step (3) to stably preserve the drug micromolecules in the pyrolysis product so as to obtain a to-be-detected solution. The lysate provided by the invention not only enables keratin to be denatured, but also destroys the melanin structure, cleaves hair more efficiently, prolongs the detection time of the preserving fluid, hasbetter repeatability, and enables the detection result to be scientific and rigorous.

The invention relates to an intelligent narcotic and psychotropic drug management system with an Internet of Things function, and belongs to the field of medical equipment. The intelligent narcotic and psychotropic drug management system comprises an intelligent narcotic and psychotropic drug management system switchboard, a supply room local area network, a router, a medium-sized device without anetworking function, a 6LoWPAN node, a device with an IPv6 protocol and a PC. A sensor technology, an RFID tag technology, a subsystem boundary routing technology and the like are applied. The intelligent narcotic and psychotropic drug management system builds a supply room local area network, collects data in the operation process of all related devices, summarizes all the data and uploads the data to a server on the Internet, so that a user can check the related data through a mobile phone or a computer or other terminals. The problem that an intelligent narcotic and psychotropic drug management system cannot uniformly upload data of all related small and medium-sized equipment such as a drug packaging machine and a drug counting machine to a server is solved. According to the intelligent narcotic and psychotropic drug management system, people can check the data of all related devices in a unified manner through the network, thereby facilitating the unified management and control of people.