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Method for synchronously detecting multiple psychotropic drugs in water body

A synchronous detection and psychiatric technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of limited removal efficiency, aquatic organism stress, and less attention to psychotropic drugs, and achieve stable recovery, strong selectivity, and linear relationship. Good results

Inactive Publication Date: 2019-02-19
HOHAI UNIV
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, due to the extensive use of such drugs and the relatively limited removal efficiency of traditional processes in sewage plants, they inevitably enter the water environment and bring potential stress effects to aquatic organisms
However, at present, the drugs of concern in the water environment are mainly antibiotics and estrogen drugs, and relatively little attention has been paid to psychotropic drugs

Method used

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  • Method for synchronously detecting multiple psychotropic drugs in water body
  • Method for synchronously detecting multiple psychotropic drugs in water body
  • Method for synchronously detecting multiple psychotropic drugs in water body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Water sample pretreatment

[0025] Measure 500 mL of water sample with a graduated cylinder, filter with a 0.45 μm glass fiber membrane to remove suspended particles in the water, adjust the pH to 2.5 to 3.0 with formic acid, and add internal standards carbamazepine-d10 and fluoxetine-d5.

[0026] (2) Solid phase extraction

[0027] Enrich the water sample with HLB (200mg, 6mL), activate the HLB solid-phase extraction column with 5mL methanol and 5mL ultrapure water in turn, then enrich the water sample at a flow rate of 3-5mL / min, and use Rinse the extraction column with 10mL of 5% methanol aqueous solution, pump under vacuum for 30min to remove water, and finally elute the target compound with 0.2% acetic acid methanol solvent to obtain an eluate containing the target compound, which is collected in a glass test tube.

[0028] (3) Nitrogen blowing to constant volume

[0029] The eluate containing the target compound obtained in step (2) was blown to near dryness...

Embodiment 2

[0053] The optimization of embodiment 2 extraction column

[0054] According to the method of Example 1, the difference is that the three types of solid-phase extraction columns HLB, C18, and MCX that are more common at present are specifically compared to the extraction efficiency of target pollution, as shown in Table 3, the results show that the HLB extraction column has The extraction efficiency of psychotropic drugs is significantly higher than that of C18 and MCX extraction columns, and the extraction efficiency is between 68% and 110%. Therefore, this method chooses HLB extraction column to extract the target substance.

[0055] Table 3: Extraction Efficiency of Different SPE Columns

[0056]

Embodiment 3

[0057] Example 3 Water Sample pH Effect Optimization on Extraction Efficiency

[0058] The rest of the experimental procedures are the same as in Example 1, except that the extraction efficiency of the target substance was compared under different pH conditions (pH=2.0, 5.0, 7.0, 9.0, 11.0) of the surface water. As shown in Table 4, the results show that the pH of the water sample is adjusted to acidic conditions, the interference of dissolved organic matter in water is removed, and the extraction column is prevented from clogging. The extraction efficiency of each substance is the highest, between 70-91%. Therefore, this experiment Adjust the pH to between 2.5-3.0.

[0059] Table 4: Extraction Efficiency of HLB Extraction Columns at Different pH

[0060]

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Abstract

The invention discloses a method for synchronously detecting multiple psychotropic drugs in a water body, and belongs to the technical field of novel pollutant enrichment detection in the water body.The method comprises the following steps of: (1) water sample pretreatment: filtering to remove suspended particulate matters in water, and adding an internal standard; (2) solid phase extraction: enriching and extracting a target compound in the water sample through an HLB solid phase extraction column; (3) blowing the collected eluted liquid nitrogen to near dryness; (4) qualitatively and quantitatively detecting the target compound by using the UPLC-MS / MS. The synchronous detection method disclosed by the invention can simultaneously detect the psychotropic drugs in the water body 16, and the method has the advantages of high accuracy, high sensitivity, and low detection limit.

Description

technical field [0001] The invention belongs to the technical field of pollutant enrichment detection in water environment, and in particular relates to a method for synchronous detection of multiple psychotropic drugs in water. Background technique [0002] The residues and pollution of drugs and personal care products in the environment have attracted the attention of scholars from all over the world, and the research on psychotropic drugs is also increasing day by day. Psychotropic drugs are commonly prescribed drugs, mainly including anti-anxiety drugs, sedatives, sleeping pills, antidepressants, etc. These drugs act directly on the central nervous system and interfere with the production of neuroendocrine signals. It has been reported that the growth and reproduction effects of aquatic organisms are changed under continuous exposure to these drugs. [0003] In recent years, due to the large-scale use of such drugs and the relatively limited removal efficiency of tradi...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/08
CPCG01N30/02G01N30/06G01N30/08G01N2030/062
Inventor 陆光华杨皓涵江润仁周冉冉章夏冬
Owner HOHAI UNIV
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