Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Conjugated psychotropic drugs and uses thereof

A technology for neuroleptics, uses, applied in the field of chemical sensitization, and can solve problems such as harmful side effects, limitations, etc.

Inactive Publication Date: 2009-06-03
RAMOT AT TEL AVIV UNIV LTD +1
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, while the teachings in WO 02 / 43652, in particular regarding the antiproliferative and chemosensitizing activities of psychostimulants in the treatment of MDR cancers, are beneficial, the use of these psychostimulants is limited by side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Conjugated psychotropic drugs and uses thereof
  • Conjugated psychotropic drugs and uses thereof
  • Conjugated psychotropic drugs and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0197] Reference is made to the following examples which, together with the foregoing description, illustrate the invention in a non-limiting manner.

[0198] Chemical Synthesis and Analysis

[0199] Exemplary chemical conjugates of the present invention were synthesized by combining the neuroleptics phenothiazine and fluphenazine with the short-chain fatty acids propionate, butyrate and valerate and with 4-phenylbutyrate and γ-aminobutyrate ( GABA) response. The compound was prepared in high yield and a crystalline solid was isolated and dissolved in 1% aqueous lactic acid.

[0200] Synthesis of chemical conjugates prepared by phenothiazine or fluphenazine and organic acids—general method: neuroleptic phenothiazine or fluphenazine (1 equivalent), acid chloride derivatives of short-chain fatty acids ( 1.1 equiv) and optional Et 3 A mixture of N (2 equivalents) (for freeing the hydrochloride salt of the starting material) in 5-10 ml of dimethylamide (DMF) was stirred at room...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Ic50aaaaaaaaaa
Login to View More

Abstract

The present invention relates to a conjugated psychotropic drugs and uses thereof. The present invention discloses novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and / or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses. The organic acids are selected to reduce side effects induced by the psychotropic drugs and / or to exert an anti-proliferative activity.

Description

[0001] This application is a divisional application of the application with the filing date of September 29, 2002, the application number of 02823600.9, and the invention title of "conjugated neuroleptic drugs and their uses". technical field [0002] The present invention relates to novel chemical conjugates of antipsychotics and organic acids and uses thereof. More specifically, the present invention relates to the combination of neuroleptics (which may also have antiproliferative and / or chemosensitizing activity) with organic acids selected for reducing side effects caused by neuroleptics and / or for producing antiproliferative activity. Novel chemical conjugates and their use in the treatment of psychiatric and / or proliferative disorders and diseases and in chemosensitization. The novel chemical conjugates of the present invention are characterized by minimizing deleterious side effects compared to prior art neuroleptics. Background technique [0003] Neuroleptics, also ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D279/18A61K31/541A61K31/54A61P25/18A61P35/00C07D417/00C07D279/28A61K31/5415A61K47/48A61P25/14
CPCA61K47/48038A61K31/5415A61K47/481A61K47/542A61K47/55A61P25/00A61P25/02A61P25/14A61P25/18A61P35/00A61P35/04A61K47/50A61K31/4965
Inventor A·努德曼A·雷哈里I·吉-阿德A·维兹曼
Owner RAMOT AT TEL AVIV UNIV LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com