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30 results about "Phosphole" patented technology

Phosphole is the organic compound with the chemical formula C₄H₄PH; it is the phosphorus analog of pyrrole. The term phosphole also refers to substituted derivatives of the parent heterocycle. These compounds are of theoretical interest but also serve as ligands for transition metals and as precursors to more complex organophosphorus compounds.

Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof

The present invention provides a biocompatible material, comprising a phospholipid or phospholipid derivative comprising various functional groups having specific chemical properties, which can function as a modular surface design unit to be incorporated or appended to a desired substrate on which it is then polymerized, thereby contributing new or specified biochemical characteristics to the polymerized and stabilized biomaterial.
Owner:EMORY UNIVERSITY

Method for catalytically hydrolyzing phosphatide bond of organic compound by virtue of cerium-based metal-organic frameworks

The invention relates to catalytic hydrolysis of a phosphatide-bond-containing organic compound, and particularly discloses a method for catalytically hydrolyzing a phosphatide bond of an organic compound by virtue of cerium-based metal-organic frameworks. The method specifically comprises the following steps: (1) ultrasonically and uniformly dispersing the cerium-based metal-organic frameworks in ammonia water; (2) adding the phosphatide-bond-containing organic compound into a solution of the cerium-based metal-organic frameworks obtained in step (1), performing oscillation for complete reaction, and extracting a fixed amount of reaction solution for centrifugal testing. According to the method, the phosphatide-bond-containing organic compound such as p-nitropenyl phosphate disodium (pNPP), dimethyl p-nitrophenyl phosphate and diethyl p-nitrophenyl phosphate is catalytically hydrolyzed by virtue of the cerium-based metal-organic frameworks, a semiautomatic perfusion system is constructed, and a high application value is achieved.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Lipoid bio-degradable polyester and preparation thereof

A phosphatidic biological degradable polyester and its production are disclosed. The production is carried out by phosphatidic group of phosphoryl choline with bionic function condensing reacting, covalent interlinking onto biological degradable polymer chain, and obtaining degradable polymer with phosphatide modification. It achieves good biological degradability, biological compatibility, and self-combing ability for medicine releasing carrier materials.
Owner:FUDAN UNIV

Method for preparing dibenzophosphole derivants

The invention discloses a method for preparing dibenzophosphole derivants. The method comprises the following steps of: taking manganese acetate as an accelerant and a diphenylphosphine oxide derivant as a reactant, and reacting in an organic solvent to obtain the dibenzophosphole derivant, wherein a structural formula of the diphenylphosphine oxide derivant is as shown in specification. According to the method, the diphenylphosphine oxide derivant which is well-sourced is used as an inhibitor to react, and therefore, various types of products can be obtained; the diphenylphosphine oxide derivant can be directly used or used for other organic synthesis reactions without anhydrous and anaerobic conditions, wherein the reaction temperature is 20-120 DEG C, the reaction conditions are mild, the reaction operation and posttreatment processes are simple, the cost is low and the yield of the target product is high.
Owner:翁后科

Enhancement of magnesium uptake in mammals

InactiveUS8017160B2Enhancing magnesium uptakeBiocideMetabolism disorderMagnesium saltCarboxylic acid
Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with one or more quaternary amines and / or phosphatides and one or more di- or tri-carboxylic acids.
Owner:RMJ160 LLC

Synthesis method of benzo[b]phospholes

The invention belongs to the organic chemical synthesis field and in particular relates to a synthesis method of benzo[b]phospholes. The synthesis method comprises the following steps: taking 1-substitued-2-bromoaryl-acetylene as a raw material, adding a dichlorophenylphosphine synthesis intermediate, and then generating a target compound through trace air catalysis. The synthesis method provided by the invention has the advantages that an oxidant, a catalyst and an additive do not need to be additionally added, and tolerance on different functional groups is good, so that the synthesis method is an environment-friendly synthesis method for a benzo[b]phospholes compound; the yield reaches more than 40%, so that the synthesis method has a good application prospect.
Owner:ZHENGZHOU UNIV

Oridonin-loaded micelle preparation and preparation method thereof

The invention discloses an oridonin-loaded micelle preparation which comprises the raw materials of oridonin, cholate and phosphatide. An associated structure of the cholate and the phosphatide is used as a carrier of the oridonin, the water solubility of the oridonin is greatly improved through reasonably setting the proportion of the components, and the stability of the preparation is good. The micelle preparation has high drug-loading rate and easy control; the raw materials have not side and toxic effects, safety and reliability, wide source and low cost, and thus the micelle preparation is very suitable for wide clinical application. The preparation method has simple process, easy implementation, good repeatability, and suitability of large-scale production; and the liquid micelle preparation can be frozen to form frozen powder, thereby being more convenient for storage and transportation.
Owner:ARMY MEDICAL UNIV

Phosphole and diphosphole ligands for catalysis

Novel reactions used to prepare phosphole and bisphosphole compounds are detailed. Novel phosphole compounds and metal coordination compounds of phosphole and bisphosphole compounds are also provided. These metal coordination compounds are useful as catalysts for the polymerization or olefins with carbon monoxide and for the polymerization of acrylic monomers.
Owner:EI DU PONT DE NEMOURS & CO

Application of Phosphatidylinositol4-kinase type II alpha PI4KIIalpha

The invention discloses a new biological function of Phosphatidylinositol4-kinase type II alpha PI4KIIalpha and an application based on the new function. PI4KIIalpha plays a key role in regulating andcontrolling a hypoxia-inducible factor HIF-1alpha and a downstream vascular endothecial growth factor VEGF. The selective reduction of PI4KIIalpha expression can obviously inhibit tumor growth and tumor angiogenesis. The PI4KIIalpha can be used as a target molecule for intervening in diseases which are relevant to a gene regulated and controlled by the HIF-1alpha and the diseases which are relevant to angiogenesis. In addition, the target molecule can be used for screening medicines for the relevant diseases.
Owner:INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES

Phospholipid compound and preparation method thereof

The invention discloses a phospholipid compound and a preparation method thereof. The structural general formula of the phospholipid compound is shown in the specification. In the formula, m is a positive integer from 2 to 10, and n is a positive integer from 7 to 15. The compound contains a disulfide bond easy to break and can be quickly broken and degraded in a reducing medium. The method comprises the following steps: (1) dissolving triphenylmethyl protected mercapto n-alkanoic acid into dimethyl sulfoxide, adding N,N'-carbonyl diimidazole, 1,8-diazabicyclo[5.4.0]undecane-7-ene and choline glycerophosphate, and carrying out a reaction to obtain bis-triphenylmethyl mercapto n-alkanoic acid choline glycerophosphate; 2) dissolving the bis-triphenylmethyl mercapto n-alkanoic acid choline glycerophosphate in dichloromethane, adding trifluoroacetic acid and triethylsilane, and carrying out a reaction to obtain bis-mercapto-alkanoic acid choline glycerophosphate; and 3) dissolving the bis-mercapto-alkanoic acid choline glycerophosphate in dichloromethane, adding n-alkyl dithiopyridine, and carrying out a reaction to obtain the bis-n-alkyl dithio-n-alkanoic acid choline glycerophosphate.
Owner:SOUTHEAST UNIV

Phospholipid compound containing unsaturated fatty acid derivative having cyclopropane ring

The invention provides a phospholipid compound containing unsaturated fatty acid having a cyclopropane ring such as 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) and 8-(2-octylcyclopropyl)octanoic acid (DCP-OA) and the like, particularly 1,2-o-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidylethanolamine (diDCP-LA-PE), which has a cognitive function improving effect and an anti-diabetes action, and which is useful as a medicine such as a therapeutic drug for dementia, a therapeutic drug for diabetes and the like.
Owner:NISHIZAKI BIOINFORMATION RES INST

Cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound and preparation method thereof

The invention relates to a cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound and a preparation method of the cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound. The structure of the compound is shown through the following formula in the specification. The preparation method includes the steps that at the temperature of 50 DEG C, trimethylchlorosilane is dripped to a solution of 1-epoxide phosphole -4-hydroxymethyl-2, 6, 7-trioxa-bicyclo [2.2.2] octane (PEPA) and an organic solvent, the temperature rises to 80 DEG C to 140 DEG C, a reaction is conducted for 5 h to 11 h through stirring, a quantitative acid-binding agent is added, stirring is conducted for 1 h, when the pH of the solution is detected as 5 to 6, the reaction is ended, after reduced pressure distillation, purification treatment is conducted, and then cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester is acquired. The compound is an excellent halogen-free phosphorus and silicon synergistic flame-retardant charring agent, can be applied to polyolefin, polyester, polyvinyl chloride, polyurethane, epoxy resin, unsaturated polyester resin and the like, and is simple in process and small in equipment investment, and industrial production can be easily achieved.
Owner:SHANDONG XINGQIANG CHEM IND TECH RES INST CO LTD

Wound exudate responsive controlled released hydrogen sulfide probe and preparation method and application thereof

The invention belongs to the technical field of medical materials, and discloses a wound exudate responsive controlled released hydrogen sulfide probe and a preparation method and application thereof. The wound exudate responsive controlled released hydrogen sulfide probe is more than one of a formula I or a formula II; R in the formula I and R in the formula II are respectively phenylene, thienyl, furylidene, pyrrolidene and phosphoropentadiene without two hydrogen atoms; R1 and R2 are independent hydrogen, C1-6 alkyl groups, C1-6 alkyloxy groups and C1-6 alkyl sulfenyl groups. The method comprises the following steps: 1) dissolving a precursor compound in an organic solvent to obtain a precursor compound solution; preparing a compound containing S < 2-> or HS <-> into a solution to obtain a sulfur-containing solution; and 2) mixing the precursor compound solution with a sulfur-containing solution to obtain the probe. The probe provided by the invention can realize quick and efficient release of hydrogen sulfide in response to wound exudate or water and real-time self-monitoring; the wound repair can be promoted, and the repair effect is good.
Owner:SOUTH CHINA UNIV OF TECH

Stable and strong anti-interference phospholipid detection reagent and detection method thereof

The present invention relates to the technical field of phospholipid detection, particularly to a phospholipid detection reagent. According to the present invention, a sodium citrate buffer solution and a Bis-Tris Propane (1,3-bis[tris(hydroxymethyl)methylamino]propane) buffer solution are respectively used in reagents R1 and R2, wherein the Bis-Tris Propane buffer solution used in the reagent is a biological buffer solution, provides good protection effects for the peroxidase used in the reagent, and does not adversely affect the reaction system, the reagent R1 contains phospholipase D, DAOS, a Triton X-305 solution, Emulgen 707, a reducing protection agent, a chelating protection agent and a preservative, and the reagent R2 contains a buffer solution, 4-aminoantipyrine, peroxidase, choline oxidase, and a preservative; and the phospholipid detection reagent has advantages of good stability and low cost, and can be widely used in the field of phospholipid detection.
Owner:BIOBASE BIODUSTRY (SHANDONG) CO LTD

Caged flame-retardant char-forming agent trimethylsilicate pepa compound and preparation method thereof

The invention relates to a cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound and a preparation method of the cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester compound. The structure of the compound is shown through the following formula in the specification. The preparation method includes the steps that at the temperature of 50 DEG C, trimethylchlorosilane is dripped to a solution of 1-epoxide phosphole -4-hydroxymethyl-2, 6, 7-trioxa-bicyclo [2.2.2] octane (PEPA) and an organic solvent, the temperature rises to 80 DEG C to 140 DEG C, a reaction is conducted for 5 h to 11 h through stirring, a quantitative acid-binding agent is added, stirring is conducted for 1 h, when the pH of the solution is detected as 5 to 6, the reaction is ended, after reduced pressure distillation, purification treatment is conducted, and then cage-shaped flame-retardant charring agent trimethyl silicic acid PEPA ester is acquired. The compound is an excellent halogen-free phosphorus and silicon synergistic flame-retardant charring agent, can be applied to polyolefin, polyester, polyvinyl chloride, polyurethane, epoxy resin, unsaturated polyester resin and the like, and is simple in process and small in equipment investment, and industrial production can be easily achieved.
Owner:SHANDONG XINGQIANG CHEM IND TECH RES INST CO LTD

A kind of supercritical method prepares nano-phosphorus-nitrogen intumescent flame retardant method

The invention discloses a method for preparing nano phosphorus-nitrogen inrumescent flame retardant melamine phosphate (MP) by means of a supercritical method. The method comprises the steps that phospholipid melamine, phosphoric acid, surface active agents and the like are weighed, and are dissolved in a little distilled water; the dissolved solution is added to a supercritical reaction kettle, temperature and pressure are controlled, and the pressure is kept for certain time; the nano phosphorus-nitrogen inrumescent flame retardant melamine phosphate (MP) is obtained by releasing the pressure. The characteristics that supercritical carbon dioxide fluid is high in solvent resistance and environmentally friendly and can be easily separated from products after preparation is finished are utilized, and the nano phosphorus-nitrogen inrumescent flame retardant is prepared. In the preparation process of the method, toxic organic solvent is not used, and pollution to environment is avoided. The prepared phosphorus-nitrogen inrumescent flame retardant is small in particle size and easy to disperse, the problem that nano particles are poor in dispersity in polymer matrixes is solved, and therefore high fire resistance is achieved. The process is simple, and cost is low.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH

Photoaffinity-labeled sphingomyelin analogs and processes thereof

A photoaffinity-labeled sphingomyelin analog of the following formula:wherein R1 is C1-20 alkylene group, R5 is C1-20 alkyl group, aryl group or C1-6 alkyl group substituted by aryl group, Z is photoaffinity-labeled group and Me is methyl group, or an optically active compound thereof.
Owner:DAISO CO LTD

Synthesis and anticancer activity of conjugated phospholipid compounds

The phospholipid compound is synthesized through reaction of P(NEt2)3, N3-(beta-ethoxyl) Tegafur, Rac-2-0-alkyl glycerine and monomer sulfur. It has a mouse LA795 lung adenocarcinoma inhibiting rate of 97.4% and a mouse liver cancer inhibiting rate of 81% in the dosage of 50 mM / Kg, higher than 61.4% and 60.5% separately of Tegafur. The present invention has novel and reasonable synthesizing process and high yield.
Owner:NANKAI UNIV

Phosphole compound

A phosphole compound represented by the formula(wherein Ar1 and Ar2 are the same or different, and represent an optionally substituted aromatic hydrocarbon ring or an optionally substituted heteroaromatic ring; Ar3 represents a divalent π-conjugated unit; R1 represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; R2 and R3 are the same or different, and represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; and Z represents a reactive group) can provide a fluorescent dye capable of maintaining a high fluorescence quantum yield irrespective of solvent polarity, and providing an improved fluorescence quantum yield and light resistance even in environments containing large amounts of water.
Owner:NAGOYA UNIVERSITY

Synthesis of Glycerolipid Carbamates and Dicarbamates and Their Use as an Antitumor Compounds

The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.
Owner:UNIVERSITY OF MANITOBA +1

Benzo polyaza and phosphole oxygen ligand and complex containing same, preparation method and application

The invention discloses a benzo polyaza and phosphole oxygen ligand and a complex containing same, a preparation method and application. The invention provides a benzo polyaza and phosphole oxygen ligand as shown in formula I and a complex containing same. A complex of the benzo polyaza and phosphole oxygen ligand and a transition metal halide enables direct coupling of carbon-carbon bonds betweenbig steric hindrance alkyl and aryl; the reaction conditions are gentle; the catalyzing efficiency is high; the coupling reaction process of the carbon-carbon bonds between big steric hindrance alkyland aryl can be extremely simplified; the practicability is high; the reaction cost can be obviously decreased, and the reaction period is reduced; the complex is free from other side products without being required in the catalyzing process. The formula refers to the description.
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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