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Biological analogue material with surface nano array and its preparing method

A nano-array and bio-simulation technology, applied in the field of bio-simulation materials and their preparation, can solve the problems of lack of long-term stability, complicated operation, and inability to provide a large enough surface.

Inactive Publication Date: 2004-07-14
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are two main limitations for monolayer transfer: (1) thermodynamic and kinetic instability make it lack long-term stability
(2) The transfer method requires the support substrate to be planar, which cannot provide a large enough surface for many important applications (such as enzyme catalysis, etc.)
However, the method of vesicle spreading also has the disadvantages of too many defects, poor stability and complicated operation.
[0014] So far there is no disclosure of biomimetic materials with surface nanoarrays on solid supported lipid membranes (phospholipid membranes)

Method used

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  • Biological analogue material with surface nano array and its preparing method
  • Biological analogue material with surface nano array and its preparing method
  • Biological analogue material with surface nano array and its preparing method

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preparation example Construction

[0045] Preparation of substrate

[0046] For the surface biomimetic material of the present invention, the substrate can use inorganic solid materials, such as semiconductor silicon, germanium, gold-plated substrates and optoelectronic devices, etc. or polymer materials, and the substrate needs to be suitable for bonding with the self-assembled layer, which can have a flat or curved surface surface.

[0047] Such as figure 1 As shown, in one embodiment of the present invention, a metal layer, such as gold, platinum, titanium, cadmium, etc., is deposited on a silicon wafer to facilitate connection with the self-assembled layer. A substrate according to another embodiment of the present invention includes a layer of titanium or cadmium with a thickness of 3-10 nanometers, and a layer of gold with a thickness of 20-500 nanometers.

[0048] In an embodiment of the invention, the metal has two layers, including a titanium layer and a gold layer. The two layers of metal can be...

Embodiment 1

[0072] Example 1 Preparation of Surface Nanoarray Material

[0073] Under high vacuum conditions, 5 nanometers of titanium and 50 nanometers of gold are first deposited on a clean silicon wafer (high-purity single crystal silicon). At 105°C, immerse the gold-coated silicon wafer in concentrated H 2 SO 4 with H 2 o 2 Washed in the mixed solution and dried with nitrogen gas. Then it was immersed in 1.5 millimoles per liter of NBT ethanol solution. After the reaction was completed, it was rinsed with organic solvents such as ethanol and chloroform successively, and dried with nitrogen. Let the low-energy electron beam (300eV) generated by the Leica LION LV 1 electron beam generation system pass through the "mask" (copper grid of 40×40μm square grid array, the square grid contains round holes with a diameter of 2.3μm), and the nitro group is selected The organically modified surface nano-array material is obtained through the reduction to the amino group, that is, a solid s...

Embodiment 2

[0074] Example 2 Preparation of Surface Nanoarray Material

[0075]Under high vacuum conditions, 8 nanometers of titanium and 100 nanometers of gold were first deposited on a clean silicon wafer. At 105°C, immerse the gold-coated silicon wafer in concentrated H 2 SO 4 with H 2 o 2 Washed in the mixed solution and dried with nitrogen gas. Then immerse it in 0.01-10 millimoles per liter of NBT ethanol solution, after the reaction, rinse with organic solvents such as ethanol and chloroform successively, and blow dry with nitrogen. Let the low-energy electron beam (300eV) generated by the Leica LION LV 1 electron beam generation system pass through the "mask" (a copper grid with a square grid array of 40×40 μm, and the square grid contains round holes with a diameter of 2.3 μm), and the nitro group is selected Reduction to amino groups (J.Vac.Sci.Technol.B 19, 2732-2735, 2001), to obtain organically modified surface nanoarray materials, that is, solid support membranes with...

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Abstract

The present invention relates to biological analogue material and is especially one kind of biological analogue material with surface nano matrix and its preparation process. The material includes substrate, one single self-assembled layer connected to the substrate and one phosphatide layer connected to the self-assembled layer. The phosphatide layer makes the present invention possess biocompatibility. The present invention combines the electronic beam printing technology and the solid support lipoid film for the first time to obtain solid supported lipoid film with surface nano array. Via chemical synthesis, phosphatide is made to joint with nano array. Meanwhile, biological material printing technology in molecular level is provided creatively.

Description

technical field [0001] The invention relates to a biological simulation material and a preparation method thereof, in particular to a biological simulation material with a surface nano array and a preparation method thereof. Background technique [0002] Materials science is at the forefront of today's high-tech development, and biomaterials is an important branch of materials science. In recent years, with the continuous progress of science and technology and the investment of a lot of manpower and material resources, the research in this area has achieved unprecedented development. [0003] The so-called biomaterials usually have two meanings. In a narrow sense, biomaterials refer to materials that can be transplanted into living organisms and can perform the same functions as the original tissues of living organisms, that is, biological tissue replacement materials. In a broad sense, biological materials are currently considered to include the following three types of ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61L33/00C23C18/16G01N27/26G01N27/327G01N33/543
Inventor 李峻柏贺强阿明・格尔卓瑟米夏埃尔・格伦策
Owner INST OF CHEM CHINESE ACAD OF SCI
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