Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Lipoid bio-degradable polyester and preparation thereof

A technology for degrading polyester and phospholipidization, applied in the field of biodegradable polymer materials, can solve the problems of poor drug permeability and slow degradation rate

Inactive Publication Date: 2006-12-06
FUDAN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since polycaprolactone is a highly crystalline polymer, its degradation rate is slow and its drug permeability is relatively poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lipoid bio-degradable polyester and preparation thereof
  • Lipoid bio-degradable polyester and preparation thereof
  • Lipoid bio-degradable polyester and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In a three-neck flask equipped with a constant pressure dropping funnel and a magnetic stirrer, add polycaprolactone with hydroxyl groups at both ends, triethylamine and dry tetrahydrofuran in a ratio of 1:2:2. Stir, use an ice-salt bath to cool the reaction system to -17°C, slowly drop in COP (2-chloro-1,3-dioxophosphoryl) dissolved in a certain amount of dry tetrahydrofuran for 3 hours, then continue to stir for 2 hours . Control the temperature at -17°C. The temperature was naturally raised to room temperature, and the reaction was stirred for 2.5 hours. The triethylamine chloride (in the form of white crystals) was removed by suction filtration, and the solvent THF was removed by rotary evaporation under reduced pressure at 30°C to obtain the white viscous product COP-PCL. Add dry acetonitrile and COP-PCL into a thick-walled single-necked flask with a stopcock, shake well, and then add a certain amount of dry trimethylamine saturated acetonitrile solution. Close ...

Embodiment 2

[0039] In a three-neck flask equipped with a constant pressure dropping funnel and a magnetic stirrer, polyglycolic acid (PGA), triethylamine and dry toluene were added in a ratio of 1:2:2. After stirring, the reaction system was cooled to 0°C with ice-salt mixture, and COP dissolved in a certain amount of dry toluene was slowly added dropwise for 3 hours, and then continued to stir for 3 hours. Control the temperature at 0°C. The temperature was naturally raised to room temperature, and the reaction was stirred for another 2 hours. The chloride of triethylamine (in the form of white crystals) was removed by suction filtration, and the solvent toluene was removed by rotary evaporation under reduced pressure at 40° C. to obtain the white viscous product COP-PGA. Add dry acetonitrile and COP-PGA into a thick-walled single-necked flask with a stopcock, dissolve, shake well, and then add a certain amount of acetonitrile saturated solution of dry trimethylamine. Close the plunger...

Embodiment 3

[0041] In a three-neck flask equipped with a constant-pressure dropping funnel and a magnetic stirrer, add dry polylactic acid (PLA) powder, triethylamine and dry dioxane whose surface was ammonolyzed with hexamethylenediamine for 2 hours in proportion. Stir to keep the system in a suspended state, use ice-salt mixture to cool the reaction system to -10°C, slowly drop in excess 100% COP dissolved in dry dioxane for 2 hours, and then continue to stir for 2 hours. Control the temperature at -10°C. The temperature was naturally raised to room temperature, and the reaction was stirred for another 2 hours. Filtration and vacuum removal of triethylamine chloride yielded white product COP-PLA. Add dry acetonitrile and COP-PLA into a thick-walled single-necked flask with a stopper, dissolve, shake well, and pass excess dry trimethylamine into it. Close the plunger, put it in a water bath, open the plunger, and heat until the residual trimethylamine is driven into the concentrated su...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A phosphatidic biological degradable polyester and its production are disclosed. The production is carried out by phosphatidic group of phosphoryl choline with bionic function condensing reacting, covalent interlinking onto biological degradable polymer chain, and obtaining degradable polymer with phosphatide modification. It achieves good biological degradability, biological compatibility, and self-combing ability for medicine releasing carrier materials.

Description

technical field [0001] The invention belongs to the technical field of biodegradable polymer materials, and in particular relates to a phospholipidated biodegradable polyester and a preparation method thereof. Background technique [0002] In the past few decades, people have been trying to develop a new type of material that can completely solve the problems of materials in biomedicine, including a variety of synthetic or natural biomaterials, but so far there are still many problems to be solved urgently. solve. [0003] It is well known that the biocompatibility of natural biological membranes should be the most ideal. Therefore, for many years, the synthesis of polymer materials similar to the structure of phospholipids in biological membranes has been an important direction for the development of biological materials. [0004] Umeda and Nakaya first synthesized a methacrylic monomer with phosphorylcholine: 2-methacryloyloxyethyl-2'-trimethylamine ethyl phosphate inner ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/91
Inventor 孟晟钟伟杜强国杨玉良
Owner FUDAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com