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Method for catalytically hydrolyzing phosphatide bond of organic compound by virtue of cerium-based metal-organic frameworks

A technology of organic compounds and organic skeletons, applied in the field of catalytic hydrolysis, can solve problems such as practical application limitations and instability of natural hydrolytic enzymes, and achieve the effects of low preparation costs, low raw material prices, and stable performance

Inactive Publication Date: 2017-06-13
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Practical applications of natural hydrolases are limited due to their instability under storage and working conditions

Method used

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  • Method for catalytically hydrolyzing phosphatide bond of organic compound by virtue of cerium-based metal-organic frameworks
  • Method for catalytically hydrolyzing phosphatide bond of organic compound by virtue of cerium-based metal-organic frameworks

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The preparation of cerium (III)-organic framework material: get 2.10g trimesic acid (H 3 BTC) was dissolved in 10mL N,N-dimethylformamide (DMF), and ultrasonically dissolved; take 4.34g cerium nitrate hexahydrate (Ce(NO 3 ) 3 ·6H 2 O) Dissolve in 45mL of water and ultrasonically dissolve; under magnetic stirring at 60°C, add the cerium nitrate solution dropwise to the trimesic acid solution, and it can be seen that the solution gradually becomes a white suspension. After continuing the reaction for 1 h, the reaction solution was centrifuged, washed with water, DMF, and ethanol several times in sequence to remove unreacted materials, and finally dried at 70°C. The resulting solid was a white powder.

Embodiment 2

[0034] Preparation of cerium (III)-organic framework material: Dissolve 2.10g of trimellitic acid in 10mL of N,N-dimethylformamide (DMF), and dissolve it by ultrasonic; take 4.34g of cerium nitrate hexahydrate (Ce( NO 3 ) 3 ·6H 2 O) dissolved in 45mL of water, ultrasonically dissolved; under magnetic stirring at 60°C, the cerium nitrate solution was added dropwise to the trimellitic acid solution. After continuing the reaction for 1 h, the reaction solution was centrifuged, washed with water, DMF, and ethanol several times in sequence to remove unreacted materials, and finally dried at 70°C.

Embodiment 3

[0036]Preparation of cerium (III)-organic framework material: Dissolve 1.66g of terephthalic acid in 10mL of N,N-dimethylformamide (DMF), and dissolve it by ultrasonic; take 4.34g of cerium nitrate hexahydrate (Ce( NO 3 ) 3 ·6H 2 O) dissolved in 45mL of water, ultrasonically dissolved; under magnetic stirring at 60°C, the cerium nitrate solution was added dropwise to the terephthalic acid solution. After continuing the reaction for 1 h, the reaction solution was centrifuged, washed with water, DMF, and ethanol several times in sequence to remove unreacted materials, and finally dried at 70°C.

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Abstract

The invention relates to catalytic hydrolysis of a phosphatide-bond-containing organic compound, and particularly discloses a method for catalytically hydrolyzing a phosphatide bond of an organic compound by virtue of cerium-based metal-organic frameworks. The method specifically comprises the following steps: (1) ultrasonically and uniformly dispersing the cerium-based metal-organic frameworks in ammonia water; (2) adding the phosphatide-bond-containing organic compound into a solution of the cerium-based metal-organic frameworks obtained in step (1), performing oscillation for complete reaction, and extracting a fixed amount of reaction solution for centrifugal testing. According to the method, the phosphatide-bond-containing organic compound such as p-nitropenyl phosphate disodium (pNPP), dimethyl p-nitrophenyl phosphate and diethyl p-nitrophenyl phosphate is catalytically hydrolyzed by virtue of the cerium-based metal-organic frameworks, a semiautomatic perfusion system is constructed, and a high application value is achieved.

Description

technical field [0001] The present invention relates to the catalytic hydrolysis of organic compounds containing phospholipid bonds, specifically a method for catalytic hydrolysis of phospholipid bonds based on cerium-based metal-organic framework materials, and the application of cerium-based metal-organic framework materials to quickly and efficiently hydrolyze organic compounds containing phospholipid bonds. compound. Background technique [0002] Organophosphorus pesticides (Organophosphate, referred to as OPS) are the main category of pesticides today, and have been produced in large quantities and widely used at home and abroad. Although the use of organophosphorus pesticides has greatly solved the problem of grain production, the unreasonable use and non-standard operation make it still have a certain degree of residue on food and in the environment, causing harm to the human body. [0003] At present, there are many degradation methods for organophosphorus pesticide...

Claims

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Application Information

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IPC IPC(8): B01J31/22B01J35/06A62D3/35A62D101/04A62D101/26A62D101/28A62D101/22
CPCA62D3/35B01J31/1691B01J31/223A62D2101/22A62D2101/28A62D2101/26A62D2101/04B01J35/59
Inventor 吴仁安张红燕李鑫
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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