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245 results about "Phosphatidylserines" patented technology

Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a SERINE moiety.

Lipids containing omega-3 and omega-6 fatty acids

A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and / or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.
Owner:ENZYMOTEC

Method for preparing phosphatidylserine and phosphatidylcholine

The invention relates to a method for preparing phosphatidylserine and phosphatidylcholine, and belongs to the field of food health-care products. The method comprises the following steps of: extracting soybean meal phospholipid which is used as a raw material by an organic solvent, and then distilling and drying to respectively obtain a phosphatidylcholine crude product and a phosphatidylserine crude product; and separating and purifying the phosphatidylcholine crude product and the phosphatidylserine crude product through a silica gel column of 200-300 meshes, eluting with a mixed organic solvent, concentrating the eluant, and drying to obtain phosphatidylserine and phosphatidylcholine. According to the method, the purities of the phosphatidylserine and the phosphatidylcholine meet requirements of new resource foods, so that the phosphatidylserine and the phosphatidylcholine can be used as new resource dietary supplements and have high economic added values; and the phosphatidylserine and the phosphatidylcholine are prepared at the same time by effectively combining simple extraction of the phosphatidylserine and the simple extraction of the phosphatidylcholine. By the method, the production time is shortened, the production cost is reduced, the production rate is improved, the operation is simple, and the products have safety.
Owner:成都圆大生物科技有限公司

Recombinant escherichia coli for producing phospholipase D and application thereof

The invention discloses a recombinant escherichia coli for producing phospholipase D and an application thereof, which belongs to the technical field of bioengineering. A phospholipase D gene is obtained through clone in Streptomyces ambofaciens by means of molecular biology measures, constructed expression plasmid is guided into E. coli BL21(DE3), and phosphatase-containing engineering bacteria formed by highly copying and recombining an expression carrier are obtained through kanamycin resistant plate screening. The recombinant phospholipase D is used for converting phosphatidylcholine and serine to generate phosphatidylserine, and efficient production of vitamin C-2-phosphate is achieved. By carrying out reaction for 2 h at the temperature of 40 DEG C with the pH value of 4.5, the yield of phosphatidylserine can reach 15.8 g / L, the conversion rate is 63.9%, and the space time yield is 7.9 g / L / h.
Owner:JIANGNAN UNIV

Health product for preventing and treating senile dementia

The invention aims at providing a health product for preventing and treating senile dementia. The health product comprises the following components in parts by weight: 3-7 parts of fructus alpiniae oxyphyllae powder, 8-12 parts of lumbricus protein, 6-14 parts of ginkgo biloba extract, 8-12 parts of lucid ganoderma extract, 3-7 parts of cortex cinnamomi extract, 3-7 parts of phosphatidylserine, 12-18 parts of gamma-aminobutyric acid, 3-7 parts of L-tryptophan, 1-3 parts of niacin, 3-7 parts of vitamin C, 2-6 parts of vitamin E, 0.3-0.7 part of vitamin B6, 0.1-0.4 part of vitamin B12 and 0.005-0.015 part of folic acid. The dosage form of the finally formed drug can be powder, tablet or capsule. The health product for preventing and treating senile dementia is prepared from pure plants or extracts, so that no toxic and side effects are caused; and the health product for preventing and treating senile dementia is simple in prescription, low in cost and good in effect.
Owner:LUOYANG HUAYI BIOTECH

Methods for treating scars and aging skin

Beneficial topical compositions for treating scar or aging skin are provided. In one embodiment, the compositions include Bulbine frutescens, Centella asiatica and a phenol derived from olives, such as oleuropein. The composition may be used in the treatment of scars formed during surgery. The composition may also be used cosmeceutically in the treatment of aged skin, and may include phosphatidylserine, vitamins, and other beneficial anti-aging ingredients.
Owner:ALLERGAN INC

Composition with auxiliary memory improvement function, preparation method of composition and capsule containing composition

The invention relates to a composition with an auxiliary memory improvement function. The composition is prepared from the following components in parts by weight: 40-60 parts of DHA spirulina oil, 30-50 parts of phosphatidylserine, 10-20 parts of safflower oil and 5-8 parts of astaxanthin oil. The composition has the technical advantage that the compatibility theory of the compound reflects the latest research results of active components and brain nutrients of the modern research; various unsaturated fatty acids of the brain nutrients and antioxidant ingredients of bioactive factors are reasonably combined; the defects of unilateral memory improvement products are overcome; overall regulation is strengthened from the basis conservation of brain cells; and a healthy brain is rebuilt.
Owner:甘肃琛蓝生物科技有限公司

Composition having effects of relieving anxiety and improving sleep and application of composition

The invention relates to a composition having effects of relieving anxiety and improving sleep. The composition comprises the following components in parts by weight: 100-200 parts of gamma-aminobutyric acid, 50-100 parts of phosphotidyl serene, 100-200 parts of a lily bulb extract, 100-200 parts of a spina date seed extract and 0.01-0.1 part of vitamin B. Experiment proves that when volunteers taking the composition provided by the invention, the sleep quality is obviously improved (situations of being impatient with anxiety, insomnia, dreaminess, and sleep disorders are obviously alleviated), and the effective rate can achieve 80% or above.
Owner:天津市康世生物技术有限公司

Water-based emulsion containing lecithin and DHA and preparation method and application of water-based emulsion

The invention provides an emulsion composition containing lecithin, DHA, other fat-soluble substances and purified water. The content of the purified water in the emulsion composition is more than 70% by weight, the weight ratio of the lecithin to the DHA is 1: (0.005-1), the particle size of fat balls in the emulsion is less than 5 mu m, and the other fat-soluble substances comprise one or more of the following components: arachidonic acid, linolenic acid, alpha-linolenic acid, gamma-linolenic acid, linoleic acid, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, polyene phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phytosterol, plant sterol ester, plant stanol ester and medium and long-chain fatty acid. The invention further provides a preparation method of the emulsion composition and application of the emulsion composition in the functional aspects of supplementing phospholipids and unsaturated fatty acids by oral administration, protecting heart and brain blood vessels, reducing blood lipids, reducing blood pressure, treating fatty liver and the like.
Owner:FUZHOU QIANZHENG PHARMA

Lipidic Compositions for Induction of Immune Tolerance

This invention provides a method for inducing immune tolerance toward an antigen comprising the antigen in lipidic particles or lipidic compositions. The lipidic particles are made up of phosphatidylserine and phosphatidylcholine, or phosphatidylinositol and phosphatidylcholine. The lipidic compositions comprise the antigen and O-phospho-L-serine. Administration of these composition results in inducing immune tolerance to the antigen.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK

Blood Retainable Device Exhibiting Selective Degradability in Tumor Tissue

A phospholipid derivative useful for the preparation of liposomes for efficient uptake of an antitumor agent or a gene intracellularly by a target tumor cell, which comprises a residue of an alcohol compound and a residue of a phospholipid, and comprising a peptide between the residue of an alcohol compound and the residue of a phospholipid, and wherein (a) the alcohol compound is an alcohol compound selected from poly(alkylene glycols) and the like, (b) the phospholipid is a phospholipid selected from phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines and the like, and (c) the peptide is a peptide comprising a substrate peptide that can serve as a substrate of a matrix metalloproteinase, provided that one amino acid residue or an oligopeptide containing 2 to 8 amino acid residues may bind to one or both ends of the substrate peptide.
Owner:HOKKAIDO UNIVERSITY +1

High-performance liquid chromatography of phosphatidylserine

The invention relates to a high-performance liquid chromatography of phosphatidylserine. The High-performance liquid chromatography comprises the steps of (1) preparing a phosphatidylserine standard solution, and using a chloroform-methanol solution to dissolve and fix the constant volume to be 80 to 400ug/ml; (2) preparing a phosphatidylserine sample solution, using the chloroform-methanol solution to dissolve and fix the volume, and diluting and preparing the sample solution of which the phosphatidylserine content is within the concentration range of standard serial solutions; (3) measuring the standard solution and the sample solution under the condition that the high-performance liquid chromatography cooperates with an evaporative light-scattering detector, performing logarithmetics on the peak area of the standard solution as a y-coordinate, performing logarithmetics on the concentration of the standard solution as an x-coordinate, drawing a double logarithmic standard curve, and finding the concentration of the sample solution from the double logarithmic standard curve according to the peak area. The high-performance liquid chromatography has the following beneficial effects: due to the fact that the high-performance liquid chromatography cooperates with the evaporative light-scattering detector, a simple and effective method is provided for the quality control during a phosphatidylserine production process through the entering of different mobile phase volume ratios.
Owner:烟台燕园科玛健康产业有限公司

Actinomycete Streptomycesbottropensis and application thereof

The invention relates to actinomycete for production of phospholipase D and application thereof and belongs to the field of biotechnology. The phospholipase D produced by the actinomycetes after fermentation has catalytic action on soybean phosphatidylcholine and L-serine to efficiently produce phosphatidylserine through transesterification. The actinomycete is collected from a wellhead NO.1066 in Dongfeng town, Dawa County, Panjin city, Liaoning province, and is identified as Streptomycesbottropensis, preserved in the key laboratory for screening of new drugs in Liaoning province under the number of SYP-A-6632, and is preserved in CGMCC under the number of CGMCC No.6993. A screening method of the Streptomycesbottropensis includes: 1, activating strains to be activated; 2, preparing a screening plate; 3, screening and decomposing lecithin strains by a plate method; 4, detecting transesterification activity. The Streptomycesbottropensis has the advantages that the operation process is simple, implementation conditions are mild, phosphatidylserine can be bio-converted efficiently and quickly, and basis of industrial production of phosphatidylserine in future is laid.
Owner:SHENYANG PHARMA UNIVERSITY
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