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Water-based emulsion containing lecithin and DHA and preparation method and application of water-based emulsion

A technology of lecithin and emulsion, applied in the field of health product composition, can solve the problems of poor oral absorption and availability of DHA and the like

Inactive Publication Date: 2015-04-08
FUZHOU QIANZHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The adverse effect is that the oral absorption and utilization of DHA is not good, and the existence of DHA greatly affects its digestion and absorption in the human body, whether it is ethyl ester type, methyl ester type or triglyceride type, in vivo They are all absorbed by passive diffusion. The absorption rate of ethyl ester type DHA is only about 20%, and the absorption rate of triglyceride type DHA in natural form is higher than that of ethyl ester type, which is only about 45%. In addition, different Formulation combination, dosage form, method of preparation or mode of presentation, which also differ significantly in bioavailability

Method used

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  • Water-based emulsion containing lecithin and DHA and preparation method and application of water-based emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment 1, lecithin DHA emulsion preparation and preparation method thereof

[0113] The prescription quantity is calculated by weight percentage and contains:

[0114] Lecithin 0.5%~5.5%, preferably 2.5%,

[0115] DHA 0.03%~1.5%, preferably 0.55%,

[0116] Sucralose 0~0.05%, preferably 0.01%,

[0117] Add purified water to 100%;

[0118] Preparation: (1) Ingredients: Weigh sucralose according to the formula and add it into purified water to dissolve completely, then weigh lecithin and DHA, add them into purified water in turn, set the volume to the required production volume, stir, mix and disperse evenly;

[0119] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 45-65°C and the stirring speed is greater than 2500r Under the condition of 1 / min, carry out the emulsification operation for 10-20 minutes...

Embodiment 2

[0124] Embodiment 2, compound phospholipid DHA emulsion preparation and preparation method thereof

[0125] The prescription quantity is calculated by weight percentage and contains:

[0126] Lecithin 0.5%~5%, preferably 4.0%,

[0127] DHA 0.03%~1%, preferably 0.5%,

[0128] Conjugated linoleic acid 0.5% to 5%, preferably 1.5%,

[0129] Arachidonic acid 0-3.5%, preferably 0.5%,

[0130] Add purified water to 100%;

[0131] Preparation: (1) Ingredients: Weigh lecithin, DHA, conjugated linoleic acid, and arachidonic acid according to the formula, add them into purified water in sequence, set the volume to the required production volume, stir, mix and disperse evenly;

[0132] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 45-65°C and the stirring speed is greater than 2800r Under the condition of 1 / min, carry ...

Embodiment 3

[0137] Embodiment 3, compound phospholipid DHA emulsion preparation and preparation method thereof

[0138] The prescription quantity is calculated by weight percentage and contains:

[0139] Lecithin 0.5% to 8%, preferably 5.0%,

[0140] DHA 0.03%~1.5%, preferably 0.5%,

[0141] Linolenic acid in peony seed oil (linolenic acid content ≥ 38%) 0.5% to 10%, preferably 1% (based on linolenic acid content),

[0142] Add purified water to 100%;

[0143] Preparation: (1) Ingredients: Weigh lecithin, DHA, and peony seed oil linolenic acid according to the formula, add them to purified water in sequence, set the volume to the required production volume, stir, mix and disperse evenly;

[0144] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 45-65°C and the stirring speed is greater than 2800r Under the condition of 1 / m...

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Abstract

The invention provides an emulsion composition containing lecithin, DHA, other fat-soluble substances and purified water. The content of the purified water in the emulsion composition is more than 70% by weight, the weight ratio of the lecithin to the DHA is 1: (0.005-1), the particle size of fat balls in the emulsion is less than 5 mu m, and the other fat-soluble substances comprise one or more of the following components: arachidonic acid, linolenic acid, alpha-linolenic acid, gamma-linolenic acid, linoleic acid, conjugated linoleic acid, conjugated linoleic acid glyceride, phosphatidylserine, polyene phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phytosterol, plant sterol ester, plant stanol ester and medium and long-chain fatty acid. The invention further provides a preparation method of the emulsion composition and application of the emulsion composition in the functional aspects of supplementing phospholipids and unsaturated fatty acids by oral administration, protecting heart and brain blood vessels, reducing blood lipids, reducing blood pressure, treating fatty liver and the like.

Description

technical field [0001] The invention relates to a health product composition, specifically a water-based oil-water emulsion containing lecithin and DHA, a preparation method and application thereof. [0002] The health product composition of the present invention refers to medicine, medical food, health food, nutritional food or cosmetics. Background technique [0003] The general name of lecithin, phosphatidylcholine, is known as the "third nutrient" alongside protein and vitamins. Since the 1990s, phospholipid research has achieved remarkable results in the fields of life science and brain science. Lecithin It has good effects on the nutrition and health of the human body, as shown in: 1. Human nutritional needs: 90% of the exogenous choline required by the human body is provided by lecithin, and lecithin provides choline with two major benefits: first, Unlike free choline, which can be degraded into methylamine due to the action of microorganisms in the intestinal tract;...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/685A61K8/55A61K8/36A61K8/06A61P3/02A61Q19/00A23L1/29A61K31/202A23L33/00
Inventor 张耿元王保红白东跃唐湘成
Owner FUZHOU QIANZHENG PHARMA
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