The invention relates to a preparation method for a novel
antifungal compound and an
antifungal application. The invention discloses a novel compound with a structure formula I as follows, wherein the novel compound is prepared by separating
Streptomyces-albolongus which is used as a source; the chemical name is (1beta, 4beta, 4abeta, 8a alpha)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-
diol; the molecular formula is C12H22O2. The invention also provides a preparation method and an application of the compound. The method provided by the invention comprises the following steps: performing fermenting culture on the strain S.albolongus, and then centrifuging, thereby acquiring a culture solution; absorbing the culture solution by a macroreticular resin column, reducing pressure and concentrating the 95%
alcohol eluting part, thereby acquiring a crude extract; treating the crude extract with
normal phase silica gel, dextrangel LH-20 and reverse phase
silica gel column chromatography, thereby acquiring a
monomer compound shown as structure I; and adopting
nuclear magnetic resonance spectrum and
mass spectrum for identifying the structure as the novel compound. An
in vitro antifungal activity research proves that the compound I provided by the invention has obvious inhibiting effect to various pathogenic fungi, including
candida albicans,
candida parapsilosis and
cryptococcus neoformans and is expected to be developed into a novel
antifungal drug.