The invention provides a full-automatic physical mutation breeding machine. The breeding machine comprises a shell (1), a hanging bracket (2), a stepping motor (3), a radiation table (4), a beam (5), rollers (6), a movable hanging bracket (7), an electromagnetic chuck (8), a vibration exciter (9), a motor (10), guide rails (11), a program control table (12), a rotating bin (13), a vibrating bin (14), a seed supporting table (15), a fixed column (16), a speed changer output shaft (17), a speed changer (18) and a rotating motor (19), wherein the radiation table (4) consists of an alpha-ray emitter (4-1), a beta-ray emitter (4-2), a gamma-ray emitter (4-3), an X-ray emitter (4-4), an ultraviolet radiator (4-5) and a microwave particle radiator (4-6). The full-automatic physical mutation breeding machine can realize free combination of various programs as well as full-automatic switching of various breeding processes during physical mutation breeding in a static state and a dynamic state, thereby having a very high application value.