The invention relates to mulberry leaf and mulberry fruit antibacterial toothpaste. The mulberry leaf and mulberry fruit antibacterial toothpaste is characterized by comprising the following materials (in percentage by weight): 12-20% calcium carbonate, 25.0-35.0% of sorbitol, 1.0-3.0% of sldium lauryl sulfate, 4.0-6.0% of a mulberry leaf and mulberry fruit extract, 1.0-3.0% of polyethylene glycol, 0.1-0.5% of trisodium phosphate, 0.1-0.3% of sodium dihydrogen phosphate, 0.002-0.005% of saccharin, 0.2-0.6% of tetrasodium pyrophosphate, 0.1-0.3% of monofluorophosphate, 1.0-2.0% of hydroxyethyl cellulose, 0.1-0.5% of a cavity refreshing agent, 2.0-3.0% of sodium dodecyl sulfate, and the balance being deionized water. The mulberry leaf and mulberry fruit toothpaste disclosed by the invention has multiple efficacies of resisting bacteria, diminishing inflammation, clearing heat, stopping bleeding, reducing swelling, stopping pains and the like, and can be used for comprehensively nursing oral cavities and protecting the health of gums and the oral cavities.