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Compound preparation used for treating radiation bone injuries and preparing method thereof

A compound preparation, a technology for bone injury, which can be applied to medical preparations containing active ingredients, bone diseases, pharmaceutical formulas, etc., can solve the problems of protracted and difficult healing, affecting the quality of life of patients, and unsatisfactory curative effects, achieving good curative effects and improving The effect of immunity and promotion of bone cell metabolism

Inactive Publication Date: 2016-07-20
刘文霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is still a lack of standard and standardized drugs for the treatment of radiation-induced bone injury in clinical practice. The main treatment is symptomatic, and most of them are treated with calcium supplements, pain relievers, and anti-inflammatory drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: The present embodiment prepares a kind of capsule of the compound preparation that is used for the treatment of radiation-induced bone injury, and by weight component, described compound preparation comprises the following main components: 98 parts of calcium gluconate, glutamine monofluorophosphate 78 parts of amide, 67 parts of Luojiaquan, 57 parts of nafcillin, 43 parts of benzisoxazole penicillin sodium, 33 parts of nandrolone phenylpropionate, 28 parts of glutathione, 26 parts of calcitonin, epimedium glycosides 24 parts, vitamin AD18 parts, stanozolol 12 parts, corticosteroids 8 parts, sucralfate 4 parts, dexamethasone 1 part, lipopolysaccharide 0.1 part, and excipient ingredients: starch 30 parts, stearic acid 5 parts , 2 parts of sodium carboxymethylcellulose, 1 part of sorbitan, and 0.03 part of butyl p-hydroxybenzoate.

[0015] Wherein, the preparation method of the icariin is as follows: take the dry product of Epimedium herba and crush it, put ...

Embodiment 2

[0020] Embodiment 2: present embodiment prepares a kind of capsule of the compound preparation that is used for the treatment of radiation-induced bone injury, by weight component, described compound preparation comprises following main components: calcium gluconate 111 parts, monofluorophosphate glutamic acid 86 parts of amide, 78 parts of Luojiaquan, 66.5 parts of nafcillin, 48.5 parts of benzisoxazole penicillin sodium, 40.5 parts of nandrolone phenylpropionate, 33.5 parts of glutathione, 30.5 parts of calcitonin, epimedium glycosides 27 parts, vitamin AD 20.5 parts, stanozolol 14.5 parts, corticosteroids 8.5 parts, sucralfate 5.5 parts, dexamethasone 1.5 parts, lipopolysaccharide 0.2 parts, and auxiliary materials: 42 parts starch, stearic acid 6.5 parts, 3 parts of sodium carboxymethylcellulose, 1.5 parts of sorbitan, 0.04 parts of butyl p-hydroxybenzoate.

[0021]Wherein, the preparation method of the icariin is as follows: take the dry product of Epimedium herba and cru...

Embodiment 3

[0026] Embodiment 3: present embodiment prepares a kind of capsule of the compound preparation that is used for the treatment of radiation-induced bone injury, by weight component, described compound preparation comprises following main components: 124 parts of calcium gluconate, glutamic monofluorophosphate Amide 94 parts, Luo Calcium 89 parts, nafcillin 76 parts, benzisoxazole penicillin sodium 54 parts, nandrolone phenylpropionate 48 parts, glutathione 39 parts, calcitonin 35 parts, epimedium glycosides 30 parts, vitamin AD 23 parts, stanozolol 17 parts, corticosteroids 9 parts, sucralfate 7 parts, dexamethasone 2 parts, lipopolysaccharide 0.3 parts, and excipient ingredients: starch 54 parts, stearic acid 8 parts , 4 parts of sodium carboxymethyl cellulose, 2 parts of sorbitan, 0.05 part of butyl p-hydroxybenzoate.

[0027] Wherein, the preparation method of the icariin is as follows: crush the dry product of Epimedium herba, put it in an extraction tank, and then add 70% ...

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PUM

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Abstract

The invention discloses a compound preparation used for treating radiation bone injuries and a preparing method thereof.The compound preparation comprises calcium gluconate, monofluorophosphate glutamine, rocaltrol, nafcillin, oxacillinum natricum, durabolin, glutathione, calcitonin, icariin, vitamin AD, stanozolol, corticosteroid, sucralfate, dexamethasone and lipopolysaccharide.The compound preparation has the effects of resisting radiation, enhancing immunity and promoting bone cell metabolism, can effectively prevent complications such as radiation osteoporosis, radiation marrow, radiation fracture, osteoradionecrosis and radiation dysostosis, the formula of the compound preparation is novel and unique, the curative effect is good, cost is low, the side effect is small, and the compound preparation is widely suitable for the radiation bone injuries.

Description

technical field [0001] The invention relates to the field of radiology medical care, in particular to a compound preparation for treating radiation-induced bone damage and a preparation method thereof. Background technique [0002] Radiation bone injury refers to a series of metabolic and clinicopathological changes in bone tissue caused by the whole body or part of the human body being exposed to a large dose of external irradiation in a short period of time, or receiving multiple external irradiation exceeding the dose equivalent limit for a long time. According to its pathological changes, it can be divided into osteoporosis, osteomyelitis, pathological fracture, osteonecrosis and bone development disorder. Among them, radiation-induced osteoporosis is the degeneration and necrosis of bone cells after bone tissue is exposed to ionizing radiation, resulting in a series of pathological changes mainly in bone density reduction; radioactive bone marrow is the basis of osteopo...

Claims

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Application Information

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IPC IPC(8): A61K38/06A61P19/08A61P19/10A61K31/191A61K31/664A61K31/593A61K31/7048A61K31/07A61K31/431A61K31/565A61K31/58A61K31/573A61K31/7024A61K31/739A61K31/59
CPCA61K31/191A61K31/07A61K31/431A61K31/565A61K31/573A61K31/58A61K31/59A61K31/593A61K31/664A61K31/7024A61K31/7048A61K31/739A61K38/06A61K2300/00
Inventor 刘文霞
Owner 刘文霞
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