33 results about "Methylcarbamic acid" patented technology

The invention discloses a synthesizing method of (S)-N-ethyl-3-[(1-dimethylamino) acetyl]-N-methyl amido phenyl formate, which is characterized by the following: adopting m-hydroxy acetophenone as raw material; synthesizing intermediate 3-(1-(dimethylamino) ethyl) phenol; condensing 3-(1-(dimethylamino) ethyl) phenol and formyl chloride to produce the product with high receiving rate.

The invention discloses a cold-resistant flame-retardant rat-proof and termite-proof communication cable. The cable comprises the following components by weight: 10-15 parts of silicone rubber, 15-20 parts of fluorinated silicone rubber, 10-15 parts of fluororubber, 3-7 parts of epoxy oil, 2-4 parts of a rare earth complex, 1-2 parts of lubricating oil, 5-15 parts of decabrominated dipheny ethane, 2-8 parts of antimonous oxide, 10-20 parts of traditional Chinese medicine extract, 2-5 parts of o-isopropylphenyl-n-methylcarbamate, 1-2 parts of paraffin, 0-5 parts of calcined clay and 1-3 parts of an antioxidant, wherein the traditional Chinese medicine extract is mixed extract of salvia japonica thunb., vervain, zanthoxylum bungeagum maxim and radix angelicae. The cable is good in cold resistance, high in tensile strength, easy to bend, convenient to construct and good in flame retardance; and the cable can be effectively prevented from being bitten by rodents, is good in rat-proof and termite-proof effects, is not cracked by frost under an outdoor low-temperature condition, ensures stable operation of communication lines, and avoids the phenomenon of an influence on operation of the communication lines caused by damage to the communication cable due to external environmental factors.

A wound repairing agent for landscape plants comprises raw materials in parts by weight as follows: 500-800 parts of EVA (ethylene vinyl acetate), 500-800 parts of gelatin, 100-200 parts of alum, 100-200 parts of erythromycin, 2-4 parts of 6-benzylaminopurine, 4-8 parts of dihydrozeatin, 3-6 parts of isopentenyladenine, 2-6 parts of isopentenyladenosine, 10-15 parts of indole-3-acetic acid, 5-10 parts of 1-naphthalene acetic acid, 12-18 parts of sulfamethoxazole, 10-12 parts of folpet, 1-5 parts of 2-methyl-5-nitroimidazole-1-ethanol, 1-3 parts of deltamethrin, 1-5 parts of acetofenate and 2-8 parts of 1-naphthyl N-methylcarbamate. The wound repairing agent can accelerate wound repairing, has a synergistic effect by adopting various auxins and cytokinins and can increase the cell division speed, thereby effectively increasing the growing speed at a wound, having an insecticidal effect on the wound and avoiding viable eggs left at the wound. The wound repairing agent can sterilize the wound, and wound infection is prevented especially by aid of killing of anaerobes in a wrapping process.

The invention belongs to the technical field of pesticide and particularly relates to a urea carbamate methyl substituted arly ester compound with bactericidal activity. The urea carbamate methyl replaced arly ester comprises N-methyl carbamate 4-(N-methyl-N'-arly ureido methyl) phenyl ester and N-methyl carbamate 2-(N-methyl-N'-arly ureido methyl) phenyl ester, and the constitutional formulas ofthe compound are respectively shown in a formula (I) and a formula (II). In the formula (I) and the formula (II), a benzene ring connected with an N atom has a substituent R, and the R can be H, 4-CH3, 4-CH3O, 4-Cl, 2-CH3, 2-CH3O, 2-Cl and 3-Cl. The compound can be applied to germ prevention and control of crops and is simple to synthesis, in addition, the used raw materials are easy to obtain.

The invention discloses a synthesizing method of (S)-N-ethyl-3-[(1-dimethylamino) acetyl]-N-methyl amido phenyl formate, which is characterized by the following: adopting m-hydroxy acetophenone as raw material; synthesizing intermediate 3-(1-(dimethylamino) ethyl) phenol; condensing 3-(1-(dimethylamino) ethyl) phenol and formyl chloride to produce the product with high receiving rate.

The invention discloses an M15 methanol gasoline vapor pressure stabilizer, which is prepared from 18.0-31.0% of N-(3-aminopropyl)-N-methyl tert-butyl carbamate, 15.0-29.5% of 2-dimethylamino-2-methyl-1-propanol, 15.0-24.5% of 6-methyl-3,5-heptadiene-2-ketone, 13.0-24.0% of diethyl tert-butyl hosphonoacetate, 10.0-20.5% of 2,2,5,5-tetramethyl tetrahydrofuran, and 9.0-19.5% of 2,3-dimethylhexane in a mixing manner. The vapor pressure stabilizer disclosed by the invention is significant in effect of reducing the vapor pressure of the M15 methanol gasoline; 0.2-0.5% of vapor pressure stabilizer is added to common M15 methanol gasoline, so that the vapor pressure of the methanol gasoline accords with the requirements of GB17930-2013 'motor gasoline'.

The invention relates to a preparation method of polysubstituted fluorine-containing six-membered nitrogen-containing heterocyclic methylamine with protecting groups. The method is carried out by using an ultrasonic extraction device. The method is characterized by comprising the following steps of: heating 2-hydroxy-5-bromopyridine-3-formic acid to 65 DEG C in methanol, performing refluxing, dropwise adding thionyl chloride, and performing a reaction to obtain 2-hydroxy-5-bromopyridine-3-methyl formate; and preparing (2-(difluoromethoxy)-5-hydroxypyridine-3-yl) methyl) tert-butyl carbamate through nine steps, and namely, obtaining the final product. The extraction is implemented by an ultrasonic extraction device, and comprises a preparation step, a covering step, a vibration shaking step, a repeating step and a receiving step. The ultrasonic extraction device comprises an extraction part (1), a shell part (2), an ultrasonic part (3), a transverse rod part (4), a left supporting part(5), a right supporting part (6), a glass device (7) and a demulsification assembly (8).

The invention relates to the field of pharmaceutical synthesis, and in particular relates to a preparation method of a rivastigmine intermediate (R)-N-ethyl-N-methyl carbamic acid-3-(1-hydroxyethyl) phenyl ester. The method employs N-ethyl-N-methyl carbamic acid-3-acetyl phenyl ester as a raw material to prepare a rivastigmine chiral intermediate compound (R)-N-ethyl-N-methyl carbamic acid-3-(1-hydroxyethyl) phenyl ester under the action of a chiral catalyst, alkali and hydrogen. The chiral catalyst is a compound with the following structure. The preparation method of the rivastigmine intermediate provided by the invention can obtain an (R) rivastigmine intermediate with high purity, and the intermediate has ee value greater than 98% through chiral HPLC analysis. The molar ratio of the catalyst only accounts for 1 / 100000-1 / 1000000 of reactant to achieve the required optical purity, and the reactant can be completely converted.

The invention relates to the field of pharmaceutical synthesis, and in particular relates to a preparation method of a rivastigmine intermediate (R)-N-ethyl-N-methyl carbamic acid-3-(1-hydroxyethyl) phenyl ester. The method employs N-ethyl-N-methyl carbamic acid-3-acetyl phenyl ester as a raw material to prepare a rivastigmine chiral intermediate compound (R)-N-ethyl-N-methyl carbamic acid-3-(1-hydroxyethyl) phenyl ester under the action of a chiral catalyst, alkali and hydrogen. The chiral catalyst is a compound with the following structure. The preparation method of the rivastigmine intermediate provided by the invention can obtain an (R) rivastigmine intermediate with high purity, and the intermediate has ee value greater than 98% through chiral HPLC analysis. The molar ratio of the catalyst only accounts for 1 / 100000-1 / 1000000 of reactant to achieve the required optical purity, and the reactant can be completely converted.

The invention discloses a preparation method for nefopam hydrochloride. The preparation method is characterized by comprising the following preparation steps: (A) performing a reaction on raw materials including tert-butyl N-benzyl-N-methyl carbamate and benzoyl chloride to obtain an intermediate tert-butyl N-(2-(benzoyl)benzyl)-N-methyl carbamate; (B) performing reduction on the intermediate tert-butyl N-(2-(benzoyl)benzyl)-N-methyl carbamate by a reductant, and performing acidolysis to obtain an intermediate 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride; and (C) performinga reaction on the intermediate 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride and chloroacetyl chloride to form an amide through a one-pot method, performing cyclization, and performing reduction by a reductant to obtain the objective compound nefopam hydrochloride. According to the invention, the reaction steps are simple, and the preparation method is easy to implement.

The invention discloses a cowpea N-methyl xylene carbamate adsorbing material, preparation and application. Ionic liquid [EPy]Br, Na2HPO4 and TEDA-PAM-Gel are mixed and react by the aid of a sol-gel method to prepare the morning-glory-shaped ionic liquid activated adsorbing material. Reaction temperature ranges from 150 DEG C to 170 DEG C, and the mass ratio of the ionic liquid [EPy]Br, the Na2HPO4 to the TEDA-PAM-Gel is 1:6:3. The adsorbing material is rapidly and conveniently prepared by the aid of the special ionic liquid, salt and grafted chelate gel, and the prepared morning-glory-shapedionic liquid activated adsorbing material has high targeting ability and collection efficiency, the recovery rate of cowpea N-methyl xylene carbamate can reach 99.5%, and the method has a wide linearrange, low detection limit and small relative standard deviation and can meet the national requirement of cowpea N-methyl xylene carbamate detection.

The invention relates to a biomass derivative methyl furan-2,5-dimethyl carbamate and a preparation method thereof. The structural formula of the compound is shown in the specification. The preparation method comprises the following steps: adding 2,5-bis (aminomethyl) furan, dimethyl carbonate and a catalyst into an atmospheric-pressure or high-pressure reactor in an inert atmosphere, and reacting for 1-7 hours to obtain a product methyl furan-2,5-dimethyl carbamate; the catalyst is sodium methoxide or zinc acetate. The obtained substance can be used as an intermediate for modification and organic synthesis of pesticides, medicines and synthetic resin; the preparation method is green and safe and has a good application prospect.

The invention discloses a synthetic method of a bromine-containing laminine ester oxamide having anti-cancer activity and a composition thereof. The method is characterized in that the novel bromine-containing laminine ester oxamide having anti-cancer activity is synthesized by using natural marine organism non-protein-laminine. The preparation process mainly comprises a synthetic process of N-(5-bromine-2-carboxyl anilino)oxalyl ethyl ester, a synthetic process of 6-N,N,N-trimethyl-2-methyl carbamate hydrochloride, and a synthetic process of bromine-containing laminine ester oxamide. The technical scheme develops high-added value application of natural sea resource, an in-vitro cytotoxic activity experiment proves that the composition has anti-cancer activity effect, is suitable for usagein field of anti-cancer drug development, and has large medical and pharmaceutical values.

The invention relates to the technical field of power pole towers, and concretely discloses a rat-bite-preventing special power pole tower formula, which is prepared from the following raw materials in parts by weight: 100 parts of SG resin, 2 to 4 parts of tribasic lead sulfate, 35 to 45 parts of nanometer calcium carbonate, 0.5 to 1.5 parts of dibasic lead phosphite, 1 to 2 parts of DOP, 1 to 3parts of epoxidized soybean oil, 1 to 2 parts of metallic soap, 1.5 to 2 parts of triphenyl phosphite, 0.2 to 0.6 part of triazine-5UV-9, 0.3 to 0.8 part of polyethylene wax, 2 to 4 parts of ACR, 4 to6 parts of CPE, 3 to 5 parts of calcium carbonate, 0.7 to 1.5 parts of capsaicine, 2 to 6 parts of O-isopropylphenyl methyl carbamate and 1 to 2 parts of 2-dimethyl cyclopropane carboxylate. The formula provided by the invention overcomes the defects in the prior art; rat-repelling ingredients prepared from the capsaicine, the O-isopropylphenyl methyl carbamate and the 2-dimethyl cyclopropane carboxylate are added; nontoxicity and harmlessness are realized; the environment pollution cannot occur; for the best advantage, rat repelling effects can be achieved; the plastic power pole tower is prevented from being bit by rats.

The invention discloses a preparation method of an isavuconazonium sulfate intermediate. The preparation method comprises the following steps: firstly, reacting absolute ethyl alcohol, sodium ethoxide and methylamine hydrochloride, cooling an obtained reaction solution, adding an ethanol solution of 1-chloroethyl methylcarbamate for continuous reaction, and conducting filtering to obtain an ethanol solution of methyl carbamic acid-1-chloroethyl ester; cooling the obtained solution, adding an ethanol solution of 2-chloro-3-pyridinemethanol for stirring reaction, filtering a reactant, removing ethanol, adding dichloromethane for dissolving, conducting washing after dissolving, and taking an organic phase, namely a dichloromethane solution of 1-chloro-ethyl (3-hydroxymethyl-pyridin-2-yl)-methylcarbamate; and firstly adding BOC-sarcosine into the obtained solution, then adding carbodiimide and 4-dimethylaminopyridine in batches for a reaction, and performing treatment after the reaction, so as to obtain the isavuconazole onium sulfate intermediate. The isavuconazonium sulfate is prepared by using the technical scheme of the invention, the side reaction of the process is less, and the purity of the obtained product is high.

A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against β-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-1 receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant.

The present invention relates to a process for manufacturing 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine of Formula (I) comprising starting from 6-chloro-2-isobutylpyrimidin-4-amine and tert-butyl azetidin-3-yl(methyl)carbamate, or another N-protected N-methylazetidin-3-amine, and performing the following steps: (a) coupling reaction of both compounds in dimethyl sulfoxide in presence of potassium carbonate to afford an intermediate protected compound; and (b) deprotection of the protected compound to afford 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine. The invention also relates to a process for manufacturing the intermediate protected compound, wherein deprotection step (b) is omitted. The invention also relates to the compounds obtained from the processes according to the invention.

The invention belongs to the technical field of design, research and development of veterinary drugs in the animal husbandry, and particularly discloses a double-solvent long-acting combined drug forkilling parasites on the body surfaces of livestock and poultry. The combined drug comprises the following components: 1.5%(w / v) of lambda-cyhalothrin, 6%(w / v) of 2-isopropoxybenzene-N-methylcarbamate, 0.2%(w / v) of phoxim, 84.8%(w / v) of food-grade white oil and the balance of a acetone substitute 15%(V / V); a preparation method thereof comprises the following steps: sequentially dissolving the lambda-cyhalothrin and the 2-isopropoxybenzene-N-methylcarbamate into the acetone substitute, and thoroughly stirring; adding the phoxim, and uniformly mixing; finally, with a mixture as a solute, dissolving again in the white oil; uniformly mixing the components in a mixer to obtain a combined drug solution with the concentration of 7.7%. The oil-type combined drug is insoluble in water, has very good adsorption performance, can form a difficultly removed drug film after being sprayed on the body surfaces of the livestock and poultry, slowly releases the drug effect, and can effectively kill theparasites on the body surfaces of the livestock and poultry.

The invention discloses a preparation method of high-purity tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate, which comprises the following steps: dissolving tert-butyl ((5-(2-fluorophenyl)-1H-pyrrole-3-yl)-N-methyl)methyl carbamate in an organic solvent, adding sodium hydride, heating for reacting, dropwise adding 3-pyridine sulfonyl chloride at low temperature, reacting under stirring for 1-3h, and filtering to obtain a solution of a tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate crude product; adding purified water to the solution, adjusting the pH to weak acidity, cooling, stirring, separating out crystals, carrying out suction filtration, drying a filter cake, pulping with an isopropyl ether and n-heptane mixed solution, carrying out suction filtration and drying to obtain a high-purity product. The process is simple, safe and reliable; the prepared vonoprazan fumarate intermediate tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate has high yield and purity, and is suitable for industrialized scaled production.

The invention discloses a method for synthesizing N-methyl carbamate, and relates to the technical field of chemical synthesis of fine chemical products. The method comprises the following steps: in an atmosphere with nitrogen in a reaction kettle, mixing urea and excessive methanol to react, after the reaction is finished, performing cooling, relieving pressure, removing reactants, recovering methanol, performing distilling, collecting a distillation section at 167-168 DEG C, and obtaining the Nmethyl carbamate. The method has the advantages of high conversion rate, accessible raw materials,simple flow, high raw material conversion rate, favorable product selectivity and favorable commercial value of byproducts, and does not use any catalyst in the preparation process, thereby reducing the trouble of the subsequent separation procedure and enhancing the production safety.

A kind of preparation method of multi-substituted fluorine-containing six-membered nitrogen-containing heterocyclic methylamine with protecting group, which utilizes an ultrasonic extraction device to carry out, is characterized in that it comprises the following steps: making 2-hydroxy-5-bromopyridine- 3-formic acid is warming up to 65 DEG C and refluxes, drips sulfur oxychloride reaction and obtains 2-hydroxyl-5-bromopyridine-3-formic acid methyl ester; Then prepare through nine steps ((2-(difluoromethoxy) ‑5‑hydroxypyridine‑3‑yl)methyl)carbamate tert-butyl ester, which is the final product; the extraction wherein is carried out using an ultrasonic extraction device, including preparation steps, capping steps, shaking and shaking steps, repeating steps, and taking step. The ultrasonic extraction device includes an extraction part (1), a shell part (2), an ultrasonic part (3), a bar part (4), a left support part (5), a right support part (6), a glass vessel (7), a broken milk components (8).

The invention discloses a drug composition used for treating MRSA. The drug composition consists of a component a), a component b) and a component c), wherein the a) is (6-fluoro-4-(6-hydroxy-3-azabicyclo[3.2.0]hept-3-yl)-2-((2-methylpyrimidine-5-yl)oxy)-9H-pyrimido[4,5-b]indole-8-yl)(methyl)carbamic acid((phosphono)oxy)methyl ester, the b) is 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-yl}oxy)benzonitrile, and the c) is a pharmaceutically acceptable excipient; and the mass ratio of the component a) to the componentb) is 3-7 : 1-5. The drug composition is extremely effective on treating diseases caused by MRSA.

A process for manufacturing 2-isobutyl-6-(3-(methylamino)azetidin-l-yl)pyrimidin-4-amine of Formula (I):including starting from 6-chloro-2-isobutylpyrimidin-4-amine and tert-butyl azetidin-3-yl(methyl)carbamate, or another N-protected N-methylazetidin-3-amine, and performing the following steps: (a) coupling reaction of both compounds in dimethylsulfoxide in presence of potassium carbonate to afford an intermediate protected compound; and (b) deprotection of the protected compound to afford 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine. Also, a process for manufacturing the intermediate protected compound, wherein deprotection step (b) is omitted, and the compounds obtained from the processes.

The invention discloses a pesticide mixture capable of attracting insect pests. Raw materials comprise the following components in parts by weight: 15-35 parts of dimethylcarbamate, 10-20 parts of amino oligosaccharin, 8-12 parts of pyrophosphate, 5-7 parts of fludioxonil, 10-20 parts of honey, 8-12 parts of sodium lignin sulfonate, 1-3 parts of hydroxymethyl cellulose, 4-6 parts of xanthan gum and 8-12 parts of tartaric acid. The pesticide mixture disclosed by the invention has the advantages that different insect pests can be killed by virtue of combination of multiple effective insecticidal ingredients, and the insect pests are attracted under the action of honey inside, so that the insecticidal efficiency is improved.

The invention provides a high-transparency low-shrinkage TPU film and a preparation method thereof. The high-transparency low-shrinkage TPU film is prepared from, in parts by weight, 100 parts of TPU particles, 30-60 parts of polycarbonate, 0.1-0.5 part of (4-hydroxycyclohexyl) methyl) tert-butyl carbamate, 0.1-0.5 part of 1-(2, 4-dihydroxy-3-trifluoromethyl-phenyl)-3-methyl-butyl-1-one and 1-3 parts of an antioxidant. The shrinkage rate of the TPU film is as low as 0.1% or below, the TPU film has good transparency, the light transmittance is 98.5% or above, the mechanical strength is high, and the TPU film is suitable for multiple fields such as automobiles, household appliances, electric appliance instruments and mechanical industry.

The invention provides an avermectin emulsion preparation, and a preparation method and application thereof, and particularly provides a pesticide preparation. The pesticide preparation is prepared from the following components in percentage by weight: 0.1-10% of avermectin, 5-45% of an organic solvent, 5-20% of an emulsifier, 0.5-3% of a stabilizer, and water, specifically, the organic solvent comprises propylene glycol diacetate and methyl methyl-carbamate. The pesticide preparation has a good killing effect on pests, long-lasting effect, quick-acting effect, good repellent effect and killing effect on pests and has a wide insecticidal spectrum, and is convenient to use, low in cost, safe and reliable. The pesticide preparation has the characteristics of high efficiency, low toxicity andlow pesticide cost.

The invention belongs to the field of pharmaceutical chemicals, and particularly relates to an ivabradine intermediate compound IV. The method for preparing the ivabradine intermediate compound IV comprises the steps of dissolving 7, 8-dimethoxy-1, 3, 4, 5-tetrahydro-benzazepin-2-one in an organic solvent, adding alkali, stirring, and dropwise adding (3-chlorine-propyl)-methyl-tert-butyl carbamate into the obtained solution to obtain the compound IV. The invention provides a novel intermediate compound IV of ivabradine, and provides a novel method for simply and efficiently preparing ivabradine by using the compound, and the whole synthesis method is simple and convenient to operate, high in reaction yield, high in purity of the obtained product, and more suitable for industrial production.