33 results about "Methylcarbamic acid" patented technology

The invention discloses a synthesizing method of (S)-N-ethyl-3-[(1-dimethylamino) acetyl]-N-methyl amido phenyl formate, which is characterized by the following: adopting m-hydroxy acetophenone as raw material; synthesizing intermediate 3-(1-(dimethylamino) ethyl) phenol; condensing 3-(1-(dimethylamino) ethyl) phenol and formyl chloride to produce the product with high receiving rate.

The invention relates to the field of pharmaceutical synthesis, and in particular relates to a preparation method of a rivastigmine intermediate (R)-N-ethyl-N-methyl carbamic acid-3-(1-hydroxyethyl) phenyl ester. The method employs N-ethyl-N-methyl carbamic acid-3-acetyl phenyl ester as a raw material to prepare a rivastigmine chiral intermediate compound (R)-N-ethyl-N-methyl carbamic acid-3-(1-hydroxyethyl) phenyl ester under the action of a chiral catalyst, alkali and hydrogen. The chiral catalyst is a compound with the following structure. The preparation method of the rivastigmine intermediate provided by the invention can obtain an (R) rivastigmine intermediate with high purity, and the intermediate has ee value greater than 98% through chiral HPLC analysis. The molar ratio of the catalyst only accounts for 1 / 100000-1 / 1000000 of reactant to achieve the required optical purity, and the reactant can be completely converted.

The invention provides an avermectin emulsion preparation, a preparation method and application thereof. Specifically, the present invention provides a kind of pesticide preparation, and described pesticide preparation contains the component of following weight ratio: 0.1-10wt% abamectin, 5-45wt% organic solvent, 5-20wt% emulsifier, 0.5-3wt% % stabilizer and water, wherein the organic solvent comprises propylene glycol diacetate and methyl methyl carbamate. The pesticide formulation of the present invention has good killing effect on pests, long lasting effect, good quick effect, good repelling effect and killing effect on pests, wide insecticidal spectrum, easy to use, low cost, safe and reliable, It has the characteristics of high efficiency, low toxicity and low cost of pesticides.

The invention discloses a synthetic method of a bromine-containing laminine ester oxamide having anti-cancer activity and a composition thereof. The method is characterized in that the novel bromine-containing laminine ester oxamide having anti-cancer activity is synthesized by using natural marine organism non-protein-laminine. The preparation process mainly comprises a synthetic process of N-(5-bromine-2-carboxyl anilino)oxalyl ethyl ester, a synthetic process of 6-N,N,N-trimethyl-2-methyl carbamate hydrochloride, and a synthetic process of bromine-containing laminine ester oxamide. The technical scheme develops high-added value application of natural sea resource, an in-vitro cytotoxic activity experiment proves that the composition has anti-cancer activity effect, is suitable for usagein field of anti-cancer drug development, and has large medical and pharmaceutical values.

The present invention relates to a process for manufacturing 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine of Formula (I) comprising starting from 6-chloro-2-isobutylpyrimidin-4-amine and tert-butyl azetidin-3-yl(methyl)carbamate, or another N-protected N-methylazetidin-3-amine, and performing the following steps: (a) coupling reaction of both compounds in dimethyl sulfoxide in presence of potassium carbonate to afford an intermediate protected compound; and (b) deprotection of the protected compound to afford 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine. The invention also relates to a process for manufacturing the intermediate protected compound, wherein deprotection step (b) is omitted. The invention also relates to the compounds obtained from the processes according to the invention.

The invention discloses a preparation method of high-purity tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate, which comprises the following steps: dissolving tert-butyl ((5-(2-fluorophenyl)-1H-pyrrole-3-yl)-N-methyl)methyl carbamate in an organic solvent, adding sodium hydride, heating for reacting, dropwise adding 3-pyridine sulfonyl chloride at low temperature, reacting under stirring for 1-3h, and filtering to obtain a solution of a tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate crude product; adding purified water to the solution, adjusting the pH to weak acidity, cooling, stirring, separating out crystals, carrying out suction filtration, drying a filter cake, pulping with an isopropyl ether and n-heptane mixed solution, carrying out suction filtration and drying to obtain a high-purity product. The process is simple, safe and reliable; the prepared vonoprazan fumarate intermediate tert-butyl ((5-(2-fluorophenyl)-1-(pyridine-3-yl sulfonyl)-1H-pyrrole-3-yl)methyl)(methyl)carbamate has high yield and purity, and is suitable for industrialized scaled production.

A kind of preparation method of multi-substituted fluorine-containing six-membered nitrogen-containing heterocyclic methylamine with protecting group, which utilizes an ultrasonic extraction device to carry out, is characterized in that it comprises the following steps: making 2-hydroxy-5-bromopyridine- 3-formic acid is warming up to 65 DEG C and refluxes, drips sulfur oxychloride reaction and obtains 2-hydroxyl-5-bromopyridine-3-formic acid methyl ester; Then prepare through nine steps ((2-(difluoromethoxy) ‑5‑hydroxypyridine‑3‑yl)methyl)carbamate tert-butyl ester, which is the final product; the extraction wherein is carried out using an ultrasonic extraction device, including preparation steps, capping steps, shaking and shaking steps, repeating steps, and taking step. The ultrasonic extraction device includes an extraction part (1), a shell part (2), an ultrasonic part (3), a bar part (4), a left support part (5), a right support part (6), a glass vessel (7), a broken milk components (8).

The invention discloses an M15 methanol gasoline vapor pressure stabilizer, which is prepared from 18.0-31.0% of N-(3-aminopropyl)-N-methyl tert-butyl carbamate, 15.0-29.5% of 2-dimethylamino-2-methyl-1-propanol, 15.0-24.5% of 6-methyl-3,5-heptadiene-2-ketone, 13.0-24.0% of diethyl tert-butyl hosphonoacetate, 10.0-20.5% of 2,2,5,5-tetramethyl tetrahydrofuran, and 9.0-19.5% of 2,3-dimethylhexane in a mixing manner. The vapor pressure stabilizer disclosed by the invention is significant in effect of reducing the vapor pressure of the M15 methanol gasoline; 0.2-0.5% of vapor pressure stabilizer is added to common M15 methanol gasoline, so that the vapor pressure of the methanol gasoline accords with the requirements of GB17930-2013 'motor gasoline'.