33 results about "Hypoglycemic product" patented technology

The invention relates to a hypoglycemic product containing cyclocarya paliurus. The hypoglycemic product mainly comprises a cyclocarya paliurus leaf water extract, a cyclocarya paliurus leaf alcohol extract, a ginkgo leaf standard extract, folium mori flavone, a bitter melon extract, a lutein and auxiliary materials. The main components are prepared into capsules or film coated tablets. The hypoglycemic product can be used for effectively lowering the blood glucose level of diabetics, and also can be used for preventing and improving targeted diabetic complication.

The invention discloses a lactobacillus rhamnosus JYLR-005 as well as a hypoglycemic product and application thereof. The lactobacillus rhamnosus JYLR-005 is preserved in China General MicrobiologicalCulture Collection Center (CGMCC for short) with the preservation number of CGMCC No. 16103. The preserved strain, i.e., the lactobacillus rhamnosus JYLR-005, is prepared into a product for oral administration. The product mainly achieves blood glucose reduction of hyperglycemic population, avoids uncomfortable symptoms caused by drugs to the body, and reduces the recurrent risk of hyperglycemia.The strain is high in gastrointestinal survival and intestinal colonization capability, and can influence generation of various short-chain fatty acids in intestinal tracts to inhibit the activity ofalpha-amylase.

The invention discloses a capsule with hypoglycemic action and process for preparation. The invention adopts panax ginseng, astragalus root, siberian solomonseal rhizome, kudzu root, poria cocos wolf, white atractylodes rhizome, schisandra fruit, gardenia, rhubarb horsetails, salvia miltiorrhizae, and glycyrrhiza which are the homology of medicine and food to be raw material. According to different properties and effective components of each raw material, and each raw material is made into capsules with carriers or findings which can be accepted in pharmacy or bromatology after the raw material is respectively disintegrated, extracted and concentrated, and granulated and the like. The invention has the advantages of simple process, easy taking, and significant curative effect, convenient long-term use, and little side effect, which is an ideal hypoglycemic product.

The invention discloses a method for producing nanometer functional sugar. The method comprises the following steps of crushing and processing raw materials in a crushing tube for 60 to 180 minutes; meanwhile, controlling the rotating speed of a stirring rod to be 2000 to 6000 r / min; in addition, controlling the ultrasonic frequency to be about 30k to 90 k Hz; finally, performing refining for 30 to 120 minutes in an airflow crushing machine; finally, obtaining the nanometer functional sugar with the particle diameter being 20 to 40 nm; controlling the molecular weight distribution of the nanometer functional sugar within 10,000 to 20,000 Da. When the nanometer functional sugar is applied to a hyperglycemic product, after the eating, the blood sugar can be obviously reduced; in the dosage range of 0.5g / kg to 2.0g / kg, the hyperglycemic effect is improved along with the dosage; in addition, the nanometer functional sugar is subjected to sulfuric acid esterification modification; the sulfuric acid esterification derivatives with good water solubility are obtained; the sulfuric acid esterification derivatives have the anticoagulation and antithrombus effects.

The invention discloses bacillus coagulans with a hypoglycemic effect and application thereof, and relates to the field of food microorganisms. The bacillus coagulans MZY531 is preserved in the China Center for Type Culture Collection on June 2, 2021; and the preservation number of the bacillus coagulans MZY531 is CCTCC NO: M2021662.The invention further discloses the application of the bacillus coagulans MZY531 in preparation of a hypoglycemic product. The bacillus coagulans MZY531 has better tolerance to artificial simulated gastrointestinal fluid, has a treatment effect on hyperglycemia of type II diabetes, and can obviously reduce the fasting blood-glucose value; the blood glucose level of a mouse with the type II diabetes can be well adjusted; the glucose intolerance condition of the mouse with the type II diabetes is improved; a good lipid-lowering effect is achieved; the host energy balance can be adjusted; and the effect of regulating the intestinal flora balance of the mice with the type II diabetes mellitus can be achieved.

The invention aims to provide a hypoglycemic product and a preparation method thereof. The product comprises balsam pear powder, mulberry leaves, gingko leaves and astragalus. The weight parts of the components are as follows: 60-65 of balsam pear powder, 1-5 of gingko leaves, 23-28 of mulberry leaves and 9-13 of astragalus. Based on the special combination of natural Chinese herbs, the invention achieves the functions of preventing, improving and reducing blood sugar. The preparation method is simple, the process conditions are stable, and the invention is applicable to the large-scale industrial production.

The invention belongs to the field of hypoglycemic products, particularly relates to a compound konjak hypoglycemic capsule and also relates to a preparation method of the compound konjak hypoglycemic capsule. The compound konjak hypoglycemic capsule contains the following components in parts by weight: 300-400 parts of konjak refined powder, 100-200 parts of propolis powder and 0.5-1 part of chromium picolinate. The konjak refined powder, the propolis powder and chromium picolinate are combined and work together to achieve an effect of effectively lowering the blood sugar. Under the guidance of the theory of traditional Chinese medicine and on the basis of scientific reasoning and experiment, the components such as the konjak refined powder, the propolis powder and so on are prepared into a hard capsule through an optimized formula. And then related functional experiments and toxicological evaluation researches prove that the hard capsule is a safe and non-toxic compound konjak hypoglycemic capsule with a function of obviously lowering the blood sugar.

The invention provides a blood glucose reducing organic oolong tea healthcare product. The blood glucose reducing organic oolong tea healthcare product is prepared from, by mass, 10-18 parts of organic oolong tea extract, 2-6 parts of anthocyanin, 2-4 parts of pu'er tea polysaccharide, 2-4 parts of laminarin and 0.5-1 part of sea cucumber polysaccharide on the basis of a dry basis. All the raw materials are fully mixed to obtain a raw material mixture, water is added, pulping is conducted through a colloid mill to obtain mixed latex liquid, a stabilizing agent is added, homogenizing is conducted, and finally spray drying is conducted to obtain the finished product. According to the blood glucose reducing organic oolong tea healthcare product, through experimental verification, the blood glucose content can be effectively reduced and stabilized really, a healthy and effective blood glucose reducing product is provided for people who have the slightly high blood glucose content, the healthcare product assists in drug therapy, and organism injuries are reduced.

The invention discloses a method for extracting hypoglycemic peptides from tea seed meal. The method comprises the following specific steps: (1) crushing the tea seed meal; (2) degreasing the tea seedmeal; (3) carrying out tea seed meal protein extraction; (4) preparing tea seed meal crude peptides; (5) separating and screening alpha-glucosidase inhibitory peptides; and (6) carrying out structureidentification of the alpha-glucosidase inhibitory peptides. Through the steps, according to the invention, three alpha-glucosidase inhibitory peptides are prepared, the amino acid sequences of the alpha-glucosidase inhibitory peptides sequentially are a(GHSLESIK), b(GLTSLDRYK) and c(SPGYDGR), and the alpha-glucosidase inhibitory peptides have very high inhibitory activities on alpha-glucosidaseand have great application prospects in development of hypoglycemic products. The raw materials involved in the invention are cheap and wide in source, and the prepared alpha-glucosidase inhibitory peptides are high in activity and have wide application prospects.

The invention discloses a compound hypoglycemic product and a preparation method thereof. The preparation method comprises the following steps: (1) weighing 15 to 20 parts by weight of coptis chinensis and 1 to 5 parts by weight of cinnamomum cassia, crushing and mixing the weighed coptis chinensis and cinnamomum cassia, putting into a water extraction tank, soaking with white spirit with 60 to 70degrees for 10 to 15 hours, moistening and desorbing according to a solid-liquid ratio of 1: (2 to 3) so as to obtain coptis chinensis and cinnamomum cassia desorption powder; (2) heating 10 to 20 times of distilled water to a temperature of 100 DEG C, pouring into the extraction tank with the coptis chinensis and cinnamomum cassia desorption powder, carrying out filtration extraction for twice for 3 to 10 min each time, merging extracting solution, concentrating into extract, and carrying out decompression drying and grinding to form 80-mesh powder for later use; and (3) taking the standby powder, carrying out gradient mixing by dextrin or soluble starch, granulating, and sub-packaging to obtain a solid product. The invention provides a pharmaceutical formula capable of effectively reducing blood sugar and blood fat and a preparation method by defining effective components in the Jiaotai pills and scientifically matching the effective components. The pharmaceutical formula has the advantages of small side effect, good curative effect and low price.

The invention relates to a laminaria japonica root hypoglycemic product and a preparation method and application thereof. The preparation method comprises the following steps that laminaria japonica roots are taken and extracted for multiple times through ethyl alcohol, an antioxidant is added during the extraction process, and an extracted concentrate is obtained; and extract liquor is added into the extracted concentrate for extraction, an antioxidant is added in the extraction process, drying is conducted, and the laminaria japonica root hypoglycemic product is obtained. The laminaria japonica roots used in the preparation method is sufficient in raw material, and the laminaria japonica root hypoglycemic product is definite in hypoglycemic effect and free of toxic and side effects, and is a safe and effective hypoglycemic product; the hypoglycemic product obtained through the preparation method has an obvious inhibition effect on alpha-glucosidase, reaches 140 [mu]g / ml in IC50, and is a noncompetitive inhibitor to the alpha-glucosidase; and an antioxidant vitamin C is added, compared with the prior art, the hypoglycemic effect IC50 is doubled or above, and meanwhile, the product yield is increased by several times.

The invention belongs to the field of natural pharmaceutical chemistry and particularly relates to naphthoquinone compounds, preparation thereof and an application to hypoglycemic product preparation.The chemical structural formula of the naphthoquinone compounds is shown as formula I in the description. Preparation comprises the following steps: Eleocharis dulcis is ground and then subjected toheat reflux extraction, and total Eleocharis dulcis extract is obtained; extraction is performed with cyclohexane and ethyl acetate sequentially, an extract is separated and purified by a silica gel chromatographic column, a Sephadex LH-20 gel column, a Toyopearl HW-40 column and a semi-preparative liquid phase C18 column, and the naphthoquinone compounds are obtained. The naphthoquinone compoundsare novel in structure and have better hypoglycemic activity which is higher than that of positive control acarbose, and an important material basis is laid for development of hypoglycemic drugs withremarkable curative effect and few toxic and side effects from medicinal and edible plants in future.

The invention discloses the hypoglycemic application of the ethanol extract of bean and taro tubers, which provides new resources for the development of natural hypoglycemic products in the fields of medicine and the like. The experimental evaluation of the HepG2 cell model constructed by high sugar induction in the present invention proves that the ethanol extract of bean and taro tubers can significantly improve the ability of HepG2 cells to consume and absorb glucose, and the effect is comprehensive and significant. Therefore, the ethanol extract of bean and taro tubers of the present invention can be applied to the preparation of hypoglycemic drugs to treat and prevent diabetes and related chronic diseases.

The invention discloses a hypoglycemic usage of an apios americana medikus flower ethyl alcohol extract. A new resource is provided for developing natural hypoglycemic products in the fields of medical science, food science and the like. According to test evaluation on an HepG2 cell model and an RINm5F cell model built through high glucose induction, the apios americana medikus flower ethyl alcohol extract can obviously improve the capability of HepG2 cell on consuming and ingesting glucose, and promotes RINm5F cell to be synthesized and secrete insulin, and the effect is comprehensive and outstanding. Therefore, the apios americana medikus flower ethyl alcohol extract can be applied to preparation of hypoglycemic food or drugs so as to cure and prevent occurrence of diabetes and related chronic diseases thereof.

The invention relates to a laminaria japonica root hypoglycemic product and a preparation method and application thereof. The preparation method comprises the following steps that laminaria japonica roots are taken and extracted for multiple times through ethyl alcohol, an antioxidant is added during the extraction process, and an extracted concentrate is obtained; and extract liquor is added into the extracted concentrate for extraction, an antioxidant is added in the extraction process, drying is conducted, and the laminaria japonica root hypoglycemic product is obtained. The laminaria japonica roots used in the preparation method is sufficient in raw material, and the laminaria japonica root hypoglycemic product is definite in hypoglycemic effect and free of toxic and side effects, and is a safe and effective hypoglycemic product; the hypoglycemic product obtained through the preparation method has an obvious inhibition effect on alpha-glucosidase, reaches 140 [mu]g / ml in IC50, and is a noncompetitive inhibitor to the alpha-glucosidase; and an antioxidant vitamin C is added, compared with the prior art, the hypoglycemic effect IC50 is doubled or above, and meanwhile, the product yield is increased by several times.

The invention discloses an application of a composition in the preparation of blood sugar reducing products. The composition includes a seaweed substance and an enzyme inhibitor. The composition can reduce the blood sugar of diabetic mice and inhibit the rise of the blood sugar of normal people, and has a slight blood sugar reducing effect; the seaweed substance has wide source and low price; and the blood sugar reducing products prepared by using the composition have a blood sugar reducing function, can be used for treating and relieving various types of diabetes and diabetic complications, have the advantages of fast acting, mild effect, obvious dose effect relationship, and no toxic side effects, can be processed to prepare various oral forms convenient for patients to use, and are safe and effective to the patients.

The invention relates to a hypoglycemic product containing cyclocarya paliurus. The hypoglycemic product mainly comprises a cyclocarya paliurus leaf water extract, a cyclocarya paliurus leaf alcohol extract, a ginkgo leaf standard extract, folium mori flavone, a bitter melon extract, a lutein and auxiliary materials. The main components are prepared into capsules or film coated tablets. The hypoglycemic product can be used for effectively lowering the blood glucose level of diabetics, and also can be used for preventing and improving targeted diabetic complication.

The invention relates to a composition with a hypoglycemic effect and a preparation method thereof. The composition is prepared from the following components in parts by weight: 3-7 parts of fenugreek, 1-7 parts of cyclocarya paliurus, 1-6 parts of folium mori, 2-8 parts of astragalus membranaceus, 2-8 parts of radix ophiopogonis, 1-6 parts of Pu'er tea and 1-6 parts of mannitol. The advantages of traditional Chinese medicine resources are fully exerted, under the guidance of traditional Chinese medicine theories, fenugreek, cyclocarya paliurus leaves, mulberry leaves, astragalus membranaceus, radix ophiopogonis and Pu'er tea are selected as raw materials, a modern and traditional combined hypoglycemic product is prepared through reasonable preparation and a modern process, and the traditional Chinese medicine hypoglycemic product is clear in function, controllable in quality, safe to take and capable of being taken for a long time.

The invention discloses application of carboxymethyl chitosan for preparing or screening products used for reducing blood glucose. Tests show that the carboxymethyl chitosan is soluble in water and blood, can be well dissolved in an acid environment of the stomache, can serve as a health product to be taken for a long time, and has an excellent effect of preventing human hyperglycemia and an effect of reducing the blood glucose.

The invention belongs to the field of medicine and health care products, and specifically discloses a compound polysaccharide, a preparation thereof and application thereof in products with the functions of clearing heat, nourishing yin and reducing blood sugar. The compound polysaccharide is prepared from rhizoma phragmitis, lalang grass rhizome, asparagus fern, Radix Ophiopogonis and folium eriobotryae. The preparation method comprises water extraction and alcohol precipitation. According to the compound polysaccharide, the food intake, water intake and urine volume of an internal heating yin deficiency type hyperglycemia rat model can be obviously reduced, and the weight of the rat is increased; the content of insulin is reduced, and the resistance to insulin is improved; triglyceride and total cholesterol are reduced, and the symptom of hyperlipidemia is improved; the immunity indexes, such as cAMP and cGMP, are reduced, and the abnormal phenomena of immunity is improved; the appearance state and spiritual attitude of internal heating yin deficiency rats are improved, the effect is obviously superior to single polysaccharide ingredients, and the compound polysaccharide can be used for preparing medicine or health food with the effects of clearing heat, nourishing yin and reducing blood sugar.

The invention belongs to the field of natural pharmaceutical chemistry and particularly relates to naphthoquinone compounds, preparation thereof and an application to hypoglycemic product preparation.The chemical structural formula of the naphthoquinone compounds is shown as formula I in the description. Preparation comprises the following steps: Eleocharis dulcis is ground and then subjected toheat reflux extraction, and total Eleocharis dulcis extract is obtained; extraction is performed with cyclohexane and ethyl acetate sequentially, an extract is separated and purified by a silica gel chromatographic column, a Sephadex LH-20 gel column, a Toyopearl HW-40 column and a semi-preparative liquid phase C18 column, and the naphthoquinone compounds are obtained. The naphthoquinone compoundsare novel in structure and have better hypoglycemic activity which is higher than that of positive control acarbose, and an important material basis is laid for development of hypoglycemic drugs withremarkable curative effect and few toxic and side effects from medicinal and edible plants in future.

The invention discloses application of carboxymethyl chitosan for preparing or screening products used for reducing blood glucose. Tests show that the carboxymethyl chitosan is soluble in water and blood, can be well dissolved in an acid environment of the stomache, can serve as a health product to be taken for a long time, and has an excellent effect of preventing human hyperglycemia and an effect of reducing the blood glucose.

The invention discloses a method for producing a product with a blood sugar level reducing function from buckwheat bran and barley. The method particularly comprises the following steps: mixing the buckwheat bran and the barley; carrying out heat-insulation enzymatic conversion; and extracting, separating, blending, and spray-drying to prepare the buckwheat bran and barley compound product which can be used for reducing the blood sugar level and preventing complications.

The invention provides a preparation method of corn stigma polysaccharide and application of the corn stigma polysaccharide in a hypoglycemic product, and relates to the technical field of extraction.The preparation method specifically comprises the steps that 1, pretreatment is conducted, specifically, corn stigma is cleaned, dried, smashed and then sieved, corn stigma powder is obtained, the corn stigma powder is soaked with ethyl alcohol, impurities are removed, and after the operation is repeated for three times, degreased corn stigma powder is obtained; (2) extraction: adding water and compound protease into the degreased corn stigma powder, soaking, carrying out primary heating extraction, cooling, then adding bromelain and the solution A, soaking, carrying out secondary heating extraction to obtain a leaching solution, and removing precipitates after enzyme deactivation and centrifugation to obtain a corn stigma polysaccharide clear solution; (3) impurity removal: dialyzing the corn stigma polysaccharide clear liquid to obtain dialyzed internal liquid; and (4) post-treatment: washing and drying the dialysis internal liquid to obtain the corn stigma polysaccharide. High-yield and high-purity corn stigma polysaccharide extraction can be realized, and the corn stigma polysaccharide can be applied to hypoglycemic products.

The invention discloses application of Yingde black tea in preparing a product for losing weight and reducing blood glucose. The weight-loss and blood-glucose-reduction product is any healthcare product or food prepared by adopting Yingde black tea extract as an active ingredient. The product can effectively inhibit the weight increase caused by feeding high-fat feed, the content increase of totalcholesterol, triglyceride and low-density lipoprotein cholesterol of the body serum and liver caused by feeding the high-fat feed can be effectively inhibited, and biochemical indexes such as the content of high-density lipoprotein cholesterol are increased; and the product disclosed by the invention can effectively inhibit the increase of fasting blood sugar in a diabetic mice body caused by tetraoxypyrimidine, can increase the sugar tolerance, the content of glycated serum protein and the content of hepatic glycogen, and can improve the pancreatic tissue morphology, thereby preventing the obesity or high-blood-glucose diseases caused by the high-fat feed or tetraoxypyrimidine.

The invention discloses a guava hypoglycemic formula and a preparation method and application thereof. The guava hypoglycemic formula comprises the following components by mass: 3-12 parts of guava aqueous extract, 1-4 parts of corn stigma aqueous extract, 1-10 parts of dandelion aqueous extract, 1.5-3 parts of lotus leaf aqueous extract and 2-5 parts of mulberry leaf aqueous extract. Guava and corn stigma used in the guava hypoglycemic formula are common food sources, dandelion, lotus leaves and mulberry leaves are all medicinal and edible raw materials, the formula can reduce the activity ofalpha-glucosidase in vitro and has hypoglycemic effect, corn stigma and lotus leaves have the effect of improving insulin resistance of fat rats, and mulberry leaves can promote insulin secretion andprotect islet cells. According to the invention, the guava extract, the dandelion extract and other extracts are mixed for use, so that the formula has a better effect of reducing the activity of alpha-glucosidase, and provides a basis for development and application of hypoglycemic products in the fields of food, health care products, medicine and the like in the future.

The invention provides a bitter gourd-based medicinal and edible hypoglycemic dietary therapy product, namely bitter gourd-balsam pear slices, and a preparation method thereof, and belongs to the field of hypoglycemic products. The bitter gourd-balsam pear slices comprise the following components: bitter gourd powder, folium mori powder, a folium mori extract, bitter gourd powder, tartary buckwheat powder, a tartary buckwheat extract, konjaku flour, spirulina powder and xylitol. The bitter gourd-balsam pear slices can help patients, who have high blood sugar after taking medicines or being injected with insulin, to reduce blood sugar, can effectively prevent diabetic complications after being eaten for a long time, can reduce or relieve dietary restrictions, greatly improves the life quality of the patients with diabetes, and can properly reduce the dosage after the blood sugar is stabilized. The bitter gourd balsam pear slice is a dietary therapy product for patients with hyperglycemia, and is mostly processed by subcontracting in 2004-2012. The bitter gourd-balsam pear slices are produced from 2015 and have consistent application results in 16 years, and so that it verifies thatthe medicinal and edible hypoglycemic dietary therapy product, namely bitter gourd-balsam pear slices, taking bitter gourd as a main raw material can effectively reduce blood sugar.

The invention relates to a hypoglycemic application of an ethyl acetate extract and an n-butyl alcohol extract of Cymbaria mongolica, and provides a new resource for developing hypoglycemic products of Cymbaria mongolica in the fields of medicine, food science and the like. Experiment evaluation of constructing a HepG2 cell insulin resistance model through insulin induction proves that both the Mongolian medicine Cymbaria ethyl acetate extract and the n-butyl alcohol extract can significantly improve HepG2 cell insulin resistance and increase glucose consumption, and the effect is significant.Therefore, the Mongolian medicine Cymbaria ethyl acetate extract and n-butyl alcohol extract can be applied to preparation of hypoglycemic drugs or food so as to prevent and treat diabetes and related chronic diseases.