Hypoglycemic application of Mongolian medicine Cymbaria ethyl acetate extract and n-butyl alcohol extract

Abstract

The invention relates to a hypoglycemic application of an ethyl acetate extract and an n-butyl alcohol extract of Cymbaria mongolica, and provides a new resource for developing hypoglycemic products of Cymbaria mongolica in the fields of medicine, food science and the like. Experiment evaluation of constructing a HepG2 cell insulin resistance model through insulin induction proves that both the Mongolian medicine Cymbaria ethyl acetate extract and the n-butyl alcohol extract can significantly improve HepG2 cell insulin resistance and increase glucose consumption, and the effect is significant.Therefore, the Mongolian medicine Cymbaria ethyl acetate extract and n-butyl alcohol extract can be applied to preparation of hypoglycemic drugs or food so as to prevent and treat diabetes and related chronic diseases.

Description

technical field [0001] 1. The present invention relates to the field of medicine and food science, in particular to a kind of hypoglycemic application of ethyl acetate extract and n-butanol extract of Mongolian medicine coreba. Background technique [0002] 2. The Mongolian medicine Xinba was first recorded in "Recognizing Medicine Baijingjian". The name of the Mongolian medicine is Alatan-Aji, and it is a plant of Cymbaria daurica L. in the family Scrophulariaceae (Scrophulariaceae). ) and the dried whole herb of C.mongolica Maxim., which belong to Mongolian medicine and have been used for hundreds of years. It has a slightly bitter taste and cool nature, and has the effects of expelling wind and dampness, diuresis, and hemostasis. It is used for yellow water sores, fetal poisoning, skin itching, scrotum itching, vaginal itching, lumps, "Qiha", traumatic bleeding, etc. , and its long-term application has made great contributions to the medical and health cause of the peopl...

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Problems solved by technology

Its main symptoms are reduced tolerance to glucose and lipid and protein metabolism disorders. At the same time, diabetes will produce many complications such as: retinopathy, optic nerve system lesions; and increase the risk of cardiovascular disease and stroke, and once Sickness requires life-long medication, which seriously endangers human health and quality of life, and brings a heavy burden to the person and the family

At present, the western medicines for the treatment of diabetes mainly include insulin secretion promoters such as glibenclamide, insulin sensitizers such as rosiglitazone and metformin, α-glucosidase inhibitors such as acarbose and diyl peptidase-VI inhibitors. Drugs, etc., but long-term use of these drugs often cause side effects of varying degrees, such as hypoglycemia, hemolytic anemia, gastrointestinal reactions, liver and kidney damage

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