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Application of carboxymethyl chitosan in the preparation of hypoglycemic products

A technology of carboxymethyl chitosan and blood sugar lowering, which is applied in the field of carboxymethyl chitosan in the preparation of products for lowering blood sugar, and can solve the problems of not disclosing the use of blood sugar lowering

Active Publication Date: 2020-11-13
SHANGHAI TAO SHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is disclosed in the prior art that carboxymethyl chitosan has the purposes of moisture absorption, moisturizing and antibacterial, but it does not disclose its use for lowering blood sugar

Method used

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  • Application of carboxymethyl chitosan in the preparation of hypoglycemic products
  • Application of carboxymethyl chitosan in the preparation of hypoglycemic products
  • Application of carboxymethyl chitosan in the preparation of hypoglycemic products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In this embodiment, carboxymethyl chitosan with a number average molecular weight of 2000 was prepared.

[0038] The carboxymethyl chitosan raw material with higher number average molecular weight is degraded with hydrogen peroxide, the number average molecular weight of the carboxymethyl chitosan raw material with higher number average molecular weight is 30W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0039] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher number-average molecular weight under stirring conditions for degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.0, until the viscosity of the reaction system is Add sodium sulfite to stop the reaction at 80-120cp, and stop the reaction when the viscosit...

Embodiment 2

[0042] Carboxymethyl chitosan with a number average molecular weight of 8000 was adopted in the present embodiment.

[0043] The carboxymethyl chitosan raw material with higher number average molecular weight is degraded with hydrogen peroxide, the number average molecular weight of the carboxymethyl chitosan raw material with higher number average molecular weight is 40W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0044] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher number-average molecular weight under agitation to carry out the degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.5 until the viscosity of the reaction system is Add sodium sulfite at 100cp to stop the reaction. In the degradation reaction, the...

Embodiment 3

[0047] Carboxymethyl chitosan with a number average molecular weight of 15,000 is used in this embodiment.

[0048] The carboxymethyl chitosan raw material with higher number average molecular weight is degraded with hydrogen peroxide, the number average molecular weight of the carboxymethyl chitosan raw material with higher number average molecular weight is 55W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0049] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher number-average molecular weight under agitation to carry out the degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.5 until the viscosity of the reaction system is At 90cp, sodium sulfite was added to stop the reaction. In the degradation reaction, the re...

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Abstract

The invention discloses application of carboxymethyl chitosan for preparing or screening products used for reducing blood glucose. Tests show that the carboxymethyl chitosan is soluble in water and blood, can be well dissolved in an acid environment of the stomache, can serve as a health product to be taken for a long time, and has an excellent effect of preventing human hyperglycemia and an effect of reducing the blood glucose.

Description

technical field [0001] The invention relates to a new application of carboxymethyl chitosan, in particular to the application of carboxymethyl chitosan in preparing products for lowering blood sugar. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial, fresh-keeping effect, and an amphoteric polyelectrolyte. It has many applications in cosmetics, fresh-keeping, medicine, etc. It is also one of the chitosan derivatives that have been studied more in recent years. [0003] The carboxymethyl group of carboxymethyl chitin is substituted on the C6-OH of the sugar residue, and a small amount of carboxymethyl group is substituted on the C3-OH, resulting in O-carboxymethyl chitin. In chitosan, the carboxymethyl group will be substituted on both -OH and -NH to generate O-carboxymethyl and N-carboxymethyl chitosan. The actual substitutions are: C6 -O-carboxymethyl, C2-N-carboxymethyl, C3-O-car...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K47/40A61K47/20A61K47/36A61P3/10C08B37/08
CPCA61K31/722A61K47/20A61K47/36A61K47/40C08B37/003
Inventor 徐宇帆
Owner SHANGHAI TAO SHENG BIOTECH CO LTD
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