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Application of composition in preparation of sweeteners and blood sugar reducing products for diabetic patients

A technology of composition and sweetener, which is applied in application, food preparation, drug combination, etc., can solve the problems of difficulty in meeting the basic dietary requirements of diabetic patients, no hypoglycemic effect, and bad flavor, so as to achieve mild effect, Fast-acting, low-cost results

Inactive Publication Date: 2014-12-17
SUZHOU SCISCAPE BIO PHARMA TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since diabetic patients should eat sugar-free or low-sugar foods, and starchy foods will be converted into sugar in the body, they should not eat more, so diabetic patients have great limitations in food choices
There is still no omnipotent food suitable for diabetic patients at present. The existing food either has high starch content and raises blood sugar (such as diabetes biscuits), or it is sugar-free and has a bad flavor, which affects appetite (such as sugar-free soybean milk powder). ), these foods are difficult to meet the basic dietary requirements of diabetic patients, and there is no hypoglycemic effect

Method used

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  • Application of composition in preparation of sweeteners and blood sugar reducing products for diabetic patients
  • Application of composition in preparation of sweeteners and blood sugar reducing products for diabetic patients
  • Application of composition in preparation of sweeteners and blood sugar reducing products for diabetic patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the combination mode of the composition of the present invention

[0030]Weigh the corresponding raw materials according to the weight ratios of seaweed substances and enzyme inhibitors in Table 1, and mix them directly to form a powder composition, or dissolve them in water to make a composition solution after mixing. The validamycin of the embodiment can be one or more mixtures of validamycin A-H (there is no difference in the inhibitory effect of enzymes using different isomers), mainly validamycin A; trehalose is trehalose (α , α), a mixture of isotrehalose (β, β) and neotrehalose (α, β).

[0031] The combination mode of table 1 composition of the present invention

[0032]

[0033] Further, the solid composition or composition solution can be used to make preparations by conventional methods, not listed one by one.

experiment example

[0034] Experimental example: the absorption situation of the composition of the present invention in the body

[0035] 1. Experimental animals and materials

[0036] Male ICR mice, 8 weeks old, weighing 20±2g, were purchased from Beijing Huafukang Experimental Animal Company;

[0037] The composition of this experimental example:

[0038] Composition 1 solution: Take 15g of trehalose and 3mg of validamycin, and prepare a composition 1 solution with 100mL of medical sterile water for use.

[0039] 2. Experimental method

[0040] After feeding the mice normally for 3 days, they were fasted for 12 hours without water, and randomly divided into 4 groups according to the blood sugar level, blank control group, drug treatment group, and negative control group 1-2. The administration group was given this experimental example composition 1 solution by intragastric administration according to the amount of 13.3mL / kg according to the body weight of the mice; 2 Inject 0.15 g / mL treha...

Embodiment 2

[0044] Example 2, the hypoglycemic effect of the composition on diabetic mice

[0045] 1. Experimental animals and materials

[0046] Male ICR mice, 8 weeks old, weighing 20±2g, were purchased from Beijing Huafukang Experimental Animal Company;

[0047] The present embodiment composition solution:

[0048] Composition 1 solution: Take 15g of trehalose and 3mg of validamycin, and prepare a composition 1 solution with 100mL of medical sterile water for use;

[0049] Composition 2 solution: take 300g of trehalose and 3mg of validamycin, and prepare a composition 2 solution with 100mL of medical sterile water for use;

[0050] Composition 3 solution: take 600g of trehalose and 3mg of validamycin, and prepare a composition 3 solution with 100mL medical sterile water, and set aside;

[0051] Composition 4 solution: take 15g of trehalose and 3mg of hexaconazole, and prepare a composition 4 solution with 100mL of medical sterile water for use;

[0052] Composition 5 solution: take...

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Abstract

The invention discloses an application of a composition in the preparation of blood sugar reducing products. The composition includes a seaweed substance and an enzyme inhibitor. The composition can reduce the blood sugar of diabetic mice and inhibit the rise of the blood sugar of normal people, and has a slight blood sugar reducing effect; the seaweed substance has wide source and low price; and the blood sugar reducing products prepared by using the composition have a blood sugar reducing function, can be used for treating and relieving various types of diabetes and diabetic complications, have the advantages of fast acting, mild effect, obvious dose effect relationship, and no toxic side effects, can be processed to prepare various oral forms convenient for patients to use, and are safe and effective to the patients.

Description

technical field [0001] The invention relates to the field of medicine and health care, in particular to the application of a composition in the preparation of sweeteners for diabetics and hypoglycemic products. Background technique [0002] Diabetes is a metabolic disease characterized by high blood sugar. Hyperglycemia is due to defective insulin secretion or impaired biological action, or both. The body of diabetic patients is in a state of high blood sugar for a long time, which will lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. In the past 15 years, the number of diabetic patients in my country has increased to 347 million. At present, diabetes has become a global problem, and diabetes has become the fifth cause of death in the world. According to statistics, there are currently more than 15 million diabetic patients in my country, with an annual growth rate of 1.5%, and the more prosperous th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/26A61K47/22A61K45/00A61K31/734A23L1/236A23L2/60A23L1/29A23L1/09A23L2/38A61P3/10A23L29/30
Inventor 张成岗李志慧李雨
Owner SUZHOU SCISCAPE BIO PHARMA TECH
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