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50 results about "Hyaluronidase activity" patented technology
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Cosmetic composition
InactiveUS20100055060A1Improve abilitiesDecrease skin roughnessOrganic active ingredientsBiocideCelluloseAlcohol
The problem of the present invention is to provide a cosmetic composition, which has a moisturizing effect, and whose ability to inhibit hyaluronidase activity is high. According to the present invention, by using one or more substances selected from sulfated cellulose and a salt thereof in combination with polyhydric alcohol, the moisturizing effect of sulfated cellulose and the ability to inhibit hyaluronidase activity can be further improved, and thereby the above-described problem can be solved. In addition, the present invention can provide a cosmetic composition having excellent stability through inclusion of an electrolyte having pH buffering ability.
Owner:JNC CORP
Moisturizing composition with anti-allergy repairing efficacy and preparation method and application of moisturizing composition with anti-allergy repairing efficacy
ActiveCN109908015ASufficient water contentAchieve a moist effectCosmetic preparationsToilet preparationsPullulanCuticle
The invention discloses a moisturizing composition with an anti-allergy repairing efficacy and preparation and application to skincare products. The composition is prepared from xanthan gum, pullulan,polyglutamic acid, hyaluronic acid, trehalose, allantoin, urea and chondroitin sulfate by reasonable compounding. The composition has a function of stereo moisturizing of all skin layers including acorium layer, an epidermal layer, a cuticle layer and a skin surface, the skin moisture content can be increased, and skin moisture loss is reduced. The composition is capable of inhibiting hyaluronidase activity, soothing skin allergy and pruritus and repairing skin barrier. The composition has excellent moisturizing effects and an anti-allergy repairing efficacy in vitro and on human skin, effects are remarkably improved as compared with those of single use of each component, and accordingly synergistic effects are achieved by combination of the components in an appropriate ratio. The composition is solid powder and free of any preservatives, and convenience in long-time storage and transport is achieved. The composition can be applied to all types of skincare and cleansing products.
Owner:SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
Composition with anti-allergy and relieving effects and preparation method and application thereof
ActiveCN105902447AFull coordinationReduce releaseCosmetic preparationsToilet preparationsMirabilis jalapaIrritation
The invention discloses a composition with anti-allergy and relieving effects and a preparation method and application thereof. The composition with anti-allergy and relieving effects has the functions of reducing allergic source irritation, inhibiting histamine release and hyaluronidase activity and repairing sensitive skin injured barriers. The composite is characterized by being mainly prepared from, by weight, 10-20% of plant extracts, 5-10% of trehalose, 20-30% of 1,3-propylene glycol and the balance water. The plant extracts mainly comprise, by weight, 10-15 parts of mirabilis jalapa, 10-15 parts of radix ophiopogonis, 10-15 parts of sophora flavescens and 5-10 parts of cactus. The composition belongs to the technical field of cosmetics.
Owner:GUANGDONG BAWEI BIOLOGICAL TECH CO LTD
Preparation method of cross-linked sodium hyaluronate gel having hyaluronidase activity inhibiting effect
The invention relates to a preparation method of a cross-linked sodium hyaluronate gel having a hyaluronidase activity inhibiting effect. The method utilizes a fact that different groups in sodium hyaluronate molecules are activated under different pH conditions, then different pH conditions are controlled, a hyaluronidase inhibitor is introduced into the sodium hyaluronate molecules, and finally the cross-linked sodium hyaluronate gel having the hyaluronidase activity inhibiting effect is obtained. Compared with a gel prepared by a traditional process, the cross-linked sodium hyaluronate gel prepared by the method has the advantages of low viscosity, long in-vivo residual time and the like, also can inhibit the hyaluronidase activity, and has the highest inhibition rate up to 65%. The low viscosity of the cross-linked sodium hyaluronate gel prepared by the method ensures convenience of clinical use, and the cross-linked sodium hyaluronate gel inhibits the hyaluronidase activity, significantly increases the in-vivo residual time, and has good application prospects in the aspects of cosmetic injections, artificial vitreous bodies and degenerative arthritis supplementary treatment.
Owner:SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
Hyaluronidase encoding gene and fermentation production and purification method thereof
The invention discloses a hyaluronidase gene having a nucleotide sequence as shown in (a) or (b) or (c), wherein the nucleotide sequence (a) is as shown in SEQ ID NO.1; the nucleotide sequence (b) is obtained by substituting, deleting or adding one or more nucleotides on the basis of the nucleotide sequence (a) and has hyaluronidase activity; and the nucleotide sequence (c) has the whole similarity of over 85% with an amino acid sequence (a) and has hyaluronidase activity. According to the invention, the efficient heterologous expression and purification of the obtained hyaluronidase from leeches is successfully realized by using a pichia pastoris expression system. A leech hyaluronidase product prepared through recombination belongs to a pharmacological active compound and can be used in the field of medicines such as drug dispersing agents and the like for treating cardiovascular and cerebrovascular diseases, ophthalmic diseases and tumor. The hyaluronidase gene lays the foundation for the industrial preparation of the hyaluronidase from the leeches.
Owner:JIANGNAN UNIV
Bacillus and method of producing hyaluronidase by employing the same
InactiveCN102559559AHigh activityImproves pH stabilityBacteriaMicroorganism based processesHyaluronidase activityMicrobiology
The invention discloses a (Bacillus) A50 CGMCC No. 5744 and a method of producing hyaluronidase by employing the same. The method is that slant cultivation, seed cultivation and fermentation cultivation are carried out for the (Bacillus) A50 CGMCC No. 5744 so that hyaluronidase is prepared. The hyaluronidase generated by the Bacillus is highly active, up to 105IU / m1. As compared with the prior art, the hyaluronidase prepared from the Bacillus of the invention is high in activity, high in thermal stability and high in pH stability, and can be used for large scale production. Meanwhile, the obtained hyaluronidase can allow high-molecular hyaluronic acid to be degraded, can be used for preparing low-molecular hyaluronic acid and oligomeric hyaluronic acid, enables the cost to be substantially reduced, helps to solve the problem of high cost for hyaluronidase of animal sources, and exhibits a wide application prospect in the field of biochemistry research and for the production of low-molecular hyaluronic acid and oligomeric hyaluronic acid.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD
Gentian compound extract and preparation method and use thereof
ActiveCN108815042ASuitable for mass productionSolve difficult filtering problemsCosmetic preparationsToilet preparationsFiltrationAllergy
The invention discloses gentian compound extract. The gentian compound extract is prepared from 10-25 parts by weight of gentian root, 5-20 parts by weight of radix scutellariae, 3-10 parts by weightof centella asiatica, 1-8 parts by weight of radix sophorae flavescentis, 1-5 parts by weight of licorice root, 1-5 parts by weight of a plant extract enzyme, 10-30 parts by weight of low molecular weight alcohol and 40-80 parts by weight of deionized water. The invention also provides a preparation method of the gentian compound extract. The preparation method comprises: raw material crushing, temperature difference method extraction, enzymatic hydrolysis extraction, enzyme inactivation treatment and extraction liquid filtration. The contents of the five raw materials and other components arecontrolled in the optimal range and have reasonable compatibility so that the inhibition rate of hyaluronidase activity can reach to 76%. The gentian compound extract can fast resist allergy and relieve itching to reduce patient's pain. The wall is broken through a temperature difference-enzymatic hydrolysis method so that the gentiopicroside content is 2180.5ppm and thus the extraction rate of the active ingredients is greatly improved, the problem that the traditional method easily causes viscous substance blocking in the filter in extraction is solved, the energy consumption and equipmentrequirements are reduced and large-scale production is feasible.
Owner:GUANGDONG DIMEI NEW MATERIAL TECH CO LTD
Composition of ashwagandha and indian gooseberry
Owner:INNOPHOS LLC
Compositions for detecting hyaluronidase activity in situ and methods of utilizing same
InactiveUS20060078500A1Microbiological testing/measurementDiagnostic recording/measuringHyaluronidase activityHyaluronic acid
A composition-of-matter is provided. The composition-of-matter comprising a chelator moiety-hyaluronan complex bound to a solid support. Also provided are methods of in-situ assessing hyaluronidase activity using such compositions.
Owner:YEDA RES & DEV CO LTD
Glycyrrhiza glabra extract and preparation method and applications thereof
InactiveCN109549966AInhibits tyrosinase activityInhibits hyaluronidase activityAntibacterial agentsCosmetic preparationsSolventBULK ACTIVE INGREDIENT
The invention discloses a glycyrrhiza glabra extract and a preparation method and applications thereof. The method comprises the following steps: (1) pulverizing fresh glycyrrhiza glabra with a colloid mill to obtain a homogenate pulverized product; and (2) adding an extraction solvent to the homogenate pulverized product obtained in the step (1), performing ultrasonic extraction to obtain an ultrasonic extractive liquid, and then subjecting the ultrasonic extractive liquid to separation and concentration so as to obtain the glycyrrhiza glabra extract. The extraction solvent is an aqueous solution of butanediol or butanediol. The method of the invention is simple in process operation and is easy to realize industrial production. The obtained glycyrrhiza glabra extract contains glycyrrhizaflavonoids, glycyrrhizin and glycyrrhiza polysaccharide, is rich in active ingredients in fresh plants, has obvious inhibition on tyrosinase activity and inhibition on hyaluronidase activity, and is suitable for whitening, anti-inflammatory and anti-allergic cosmetics.
Owner:广州诗美化妆品有限公司
Antipyrotic
InactiveCN101198341AInhibition releaseInhibit aggregationOrganic active ingredientsCosmetic preparationsOrganic solventMedicine
An anti-inflammatory agent which comprises an oil-soluble licorice extract obtained by extraction treatment of either a leguminous plant of the genus Glycyrrhiza or a water extract of a leguminous plant of the genus Glycyrrhiza with an organic solvent, and has at least one effect selected from an inhibitory effect on hyaluronidase activity, an inhibitory effect on hexosaminidase release (i.e., an inhibitory effect on histamine release), an inhibitory effect on platelet aggregation and an inhibitory effect on phospholipase A2 activity.
Owner:MARUZEN PHARMA
Aloe flower extract and preparation method thereof
PendingCN108635301AEnhanced inhibitory effectDPPH free radical scavenging rate is goodCosmetic preparationsAntipyreticDPPHIrritation
The invention relates to aloe flower extract and a preparation method thereof and in particular relates to moisturizing, anti-inflammatory, anti-oxidization and whitening aloe flower extract and a preparation method thereof. The aloe flower extract prepared by the preparation method is subjected to experiments including hyaluronidase activity inhibition, DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical inhibition, reduction capability, tyrosinase activity inhibition and the like to prove the effects in moisturizing, repairing, anti-oxidization and whitening aspects; the aloe flower extract can be used for preparing moisturizing, anti-allergy, whitening and anti-ageing cosmetics and has the effects of increasing the hydration of skin and reducing irritation of external environment on skin,reducing injuries of free radicals on the skin, inhibiting the generation of melanin and helping the skin to recover a healthy state.
Owner:云南万绿生物股份有限公司 +1
Extracellular yaluronidase from streptomyces koganeiensis
The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.
Owner:FIDIA FARMACEUTICI SPA
Hyaluronidase inhibitor as well as preparation method and use thereof
InactiveCN101480407AImprove stabilityImprove durabilityOrganic active ingredientsAntipyreticChromatographic separationPositive control
The invention provides a new method for preparing 1, 2, 3, 4, 6-five-O-galloyl-Beta-D- glucose (PGG) by using tannin and the new use thereof. The tannin is hydrolyzed by acid to prepare a PGG crude product, and chromatographic separation and purification are then carried out on the PGG crude product by macroporous absorbent resin and hyskon gel columns to obtain PGG with the purity quotient more than 90 percent. The PGG prepared by the method has good colour and lustre, high purity quotient, simple, safe and easy preparation process, low cost, short production period and easy batch preparation and commercial process. The activity rating shows that the inhibited effect (IC50 0.01mM) of the PGG for the activity of hyaluronate lyase is obviously higher than that of positive control cromolyn sodium (IC50 6.99mM), and the PGG can be directly used as a raw material or the additive of medicine, health food and cosmetics.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Immune cell expressing hyaluronidase and application thereof
ActiveCN110713983AImprove permeabilityShort half-lifePolypeptide with localisation/targeting motifPeptide/protein ingredientsExtracellularCell-Extracellular Matrix
The present invention provides an immune cell expressing hyaluronidase and an application thereof. The immune cell comprises a fusion gene and the fusion gene mainly comprises a signal peptide, a hyaluronic acid catalytic active region, and a stable sequence in series. The signal peptide is the signal peptide of secreted proteins. The provided immune cell expressing the hyaluronidase can express and secrete the hyaluronidase as a protein, the hyaluronidase is secreted outside the cell to degrade extracellular matrix, in a natural state, half-life of the hyaluronidase is relatively short, so that hyaluronidase active sequence is fused with a signal peptide sequence and the stable sequence, which can extend the half-life of the hyaluronidase in body, promotes infiltration of the immune cellto specific tissues and thus increases functional activity of the immune cell against solid tumors.
Owner:SHENZHEN IN VIVO BIOMEDICINE TECH LTD
Water-soluble microemulsion and preparation method thereof
InactiveCN112675077ASimple preparation processStable in natureAntibacterial agentsCosmetic preparationsPropanoic acidHemolysis
The invention discloses a water-soluble microemulsion. The water-soluble microemulsion is characterized in that the microemulsion comprises cannabidiol, a surfactant, a cosurfactant and water, and comprises the following components in percentage by weight of 0.5-5wt% of industrial hemp full-spectrum oil, 2 to 40 wt% of PPG-13-decyl tetradecyl alcohol polyether-24; 2-40 wt% of PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol, and the balance of water. The microemulsion disclosed by the invention is clear and transparent in color, is uniformly distributed into liquid drops with the particle size of about 10-30nm, is good in thermodynamic stability, and is not layered after being stored for a long time. Meanwhile, the microemulsion can effectively inhibit hyaluronidase activity, inhibit secretion of human keratinocyte IL-8 and promote generation of IL-10, remarkably inhibit growth of staphylococcus aureus and propionibacterium acnes and remove free radicals, and does not generate obvious blood coagulation or hemolysis reaction, so that inflammatory response of skin is relieved, and anti-inflammatory and soothing effects are achieved.
Owner:云南银橙汉普生命科学研究股份有限公司
Peach blossom extract and application thereof
InactiveCN108014191ALow toxicityImprove medicinal effectCosmetic preparationsAntipyreticHyaluronidase activitySolvent
The invention relates to peach blossom extract and an application thereof and particularly relates to an application of peach blossom extract in inhibiting hyaluronidase activity. The peach blossom extract is a solid product which is light yellow or rose red to dark red and is prepared through carrying out ultrasonic extraction on peach blossom through water or a hydrophilic solvent and an aqueoussolution and carrying out reduced pressure concentration distillation drying. The peach blossom extract can be processed into various preparations. In order to verify the effect of the peach blossomextract on the activity of hyaluronidase, the hyaluronidase and peach blossom extract form a reaction system, the absorption value at 400nm of the reaction system is determined, and according to the absorption values of the sample and control, the inhibition ratio of the peach blossom extract to the hyaluronidase is calculated. The result shows that the peach blossom extract has the significant inhibitory effect on the activity of hyaluronidase and the inhibitory effect is increased along with increasing of the application dose. The peach blossom extract has a good concentration-dependent effect and has a semi-suppressed dose (IC50) to the hyaluronidase activity of 0.25 mg / mL.
Owner:ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI
Extracellular yaluronidase from streptomyces koganeiensis
The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.
Owner:FIDIA FARMACEUTICI SPA
Method for preparing 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG)
InactiveCN101962394AImprove stabilityImprove durabilityEsterified saccharide compoundsSugar derivativesPositive controlSodium cromoglicate
The invention provides a novel method for preparing 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) by tannin, which comprises the following steps of: hydrolyzing tannin with acid to obtain a PGG rough product; and separating and purifying by using macroporous absorption resin and glucan gel column chromatography to obtain the PGG with the purity of larger than 90 percent. The method has the advantages of good color and high purity of the obtained PGG, simple, safe and easy preparation process, lower cost and short production period and is easy for mass preparation and industrialized production. Indicated by activity evaluation, the inhibiting action (IC50 0,01mM) of the PGG on hyaluronidase activity is obviously higher than that of positive control sodium cromoglycate (IC50 6.99mM), and the PGG can be directly used as a raw material of a medicament, a heat care food and cosmetics or additive thereof.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Application of bamboo fungus spore composition in cosmetics
InactiveCN106389179AExcellent skin beautification effectInhibitory activityCosmetic preparationsAntipyreticDual effectElution
The invention discloses an application of a bamboo fungus spore composition in cosmetics. The composition mainly comprises 1-50 wt% of bamboo fungus spore powder and 0.1-20 wt% of bamboo fungus powder extract as main components. The bamboo fungus spore powder is obtained after elution, drying and ultrafine crushing; and the bamboo fungus spore extract is obtained through extracting wall-broken bamboo fungus spores with a solvent, filtering or centrifuging the obtained solution to obtain an extract liquid, and concentrating the extract liquid into an extract. The bamboo fungus spore powder and the bamboo fungus powder extract are mixed according to a certain ratio, and cosmetically acceptable auxiliary materials are added to produce the cosmetics. The cosmetics have a substantial skin whitening effect, and the composition effectively inhibits in vivo tyrosinase activity, inhibits self oxidation and deepening of dopa, prevents infringement of free radicals to skin cells and effectively inhibits hyaluronidase activity in order to realize inflammation prevention and cooperative moisture retention dual effects.
Owner:INST OF SOIL & FERTILIZER FUJIAN ACADEMY OF AGRI SCI
Skin care composition with sensitive skin relieving and repairing effects as well as preparation and application thereof
InactiveCN108434063ARepair barrier functionLess irritatingCosmetic preparationsToilet preparationsBetaineIrritation
The invention belongs to the technical field of cosmetics and discloses skin care composition with sensitive skin relieving and repairing effects as well as preparation and application thereof. The composition is prepared from 10% to 20% of plant extract, 5% to 10% of glycine betaine, 20% to 30% of 1,3-propylene glycol and water, wherein the plant extract includes flos chrysanthemi indici extract,herba dendrobii officinale extract, radix sophorae flavescentis extract and aloe extract. The preparation of the skin care composition comprises the steps: heating deionized water to 70 to 90 DEG C,adding the glycine betaine and the 1,3-propylene glycol and stirring and dissolving evenly; cooling 45 DEG C or less, adding the plant extract and stirring and dissolving evenly to obtain the skin care composition with the sensitive skin relieving and repairing effects. The composition disclosed by the invention is prepared from the natural relieving raw materials; when the composition is appliedto skin care products, the composition can reduce histamine release, inhibit hyaluronidase activity, repair a skin barrier function and reduce skin care product irritation and has the effects of moderating, relieving and repairing the sensitive skin.
Owner:SOUTH CHINA INST OF COLLABORATIVE INNOVATION +1
Method for rapid determination of hyaluronidase activity
InactiveCN105524977AShort timeThe test result is accurateMicrobiological testing/measurementSodium acetrizoateSodium acetate
The present invention discloses a method for rapid determination of hyaluronidase activity, and the method comprises the following steps: (1) using a sodium acetate-acetic acid buffer solution for preparation of a hyaluronic acid solution with the pH value greater than 3 and less than or equal to 7; (2) preparing a cetyl trimethyl ammonium bromide solution; (3) taking the hyaluronic acid solution of the step (1), adding a hyaluronidase solution for reacting for 0.5 to 1 hour at 37 DEG C, and adding the cetyl trimethyl ammonium bromide solution for reacting at 37 DEG C for 8 to 15 minutes to obtain a sample solution; (4) preparing a control solution, to be more specific, taking the hyaluronic acid solution of the step (1), and adding the cetyl trimethyl ammonium bromide solution for reacting at 37 DEG C for 8 to 15 minutes to obtain a control solution; (5) using a microplate reader to determine optical density values of the sample solution and the control solution at a wavelength of 400nm; and (6) according to the obtained optical density values of the sample solution and the control solution, calculating hyaluronidase activity and specific activity. The method is simple to operate, good in stability and high in sensitivity and reproducibility, and lays a foundation for scale extraction, preparation and application of hyaluronidase.
Owner:GUANGZHOU MEDICAL UNIV
Solution with anti-oxidization, restoration, anti-winkle and water supplementation functions and preparation method thereof
InactiveCN108685730AImprove water retentionGood moisturizing effectCosmetic preparationsToilet preparationsAdditive ingredientHyaluronidase activity
The invention relates to a solution with anti-oxidization, restoration, anti-winkle and water supplementation functions and a preparation method thereof. The solution is prepared from hydrolyzed sodium hyaluronate, sodium polyglutamate, phenoxyethanol and water. The solution provided by the invention has the advantages that the cooperated enhancing effect of all ingredients is achieved; the long effect moisture preservation is realized; the enzymatic activity of hyaluronic acid is inhibited; the natural moisture preservation factors are generated; the skin elasticity is maintained; the monophenyl oxidase activity is mildly inhibited; the melanin generation is inhibited; the oxidization and pigmentation can be resisted; the deep layer moisture preservation is realized; the luster whiteningeffect is achieved. The skin feeling of the solution is smooth but not greasy.
Owner:TIANJIN RUANYIN TECH CO LTD
Modified Porphyran
InactiveUS20050201962A1Ensure stability of its physical propertyConveniently producedCosmetic preparationsOrganic active ingredientsSulfateSulphate Ion
Porphyran with modified bioactivity and physical property, method of making the modified Porphyran and use of modified Porphyran. Porphyran with modified bioactivity and physical property is produced by dissociating a salt from a sulphate group in Poryphran and removing it, making Porphyran having a free sulphate group wherein a salt is dissociated. Further, Porphyran with modified bioactivity and physical property is produced by dissociating a salt from sulphate group in Porphyran and removing it, and then altering the sulphate group, with the use of a given salt, into a sulphate salt of the given salt. The modified Porphyran also can be obtained by converting a salt of a sulphate group in Porphyran into a sulphate salt of a given salt by ion exchange. The modified Porphyran be added to cosmetics, food, and drink, and used as cosmetic, food and drink having inhibitory activity against hyaluronidase activity.
Owner:SHIRAKO CO LTD KK SHIRAKO
A kind of hyaluronidase coding gene and its fermentation production and purification method
The present invention discloses a hyaluronidase gene, the nucleotide sequence of which is shown in (a) or (b) or (c): (a) the nucleotide sequence is shown in SEQ ID NO.1; (b) in The nucleotide sequence in (a) has been substituted, deleted or added a nucleotide or a few nucleotides and has hyaluronidase activity; (c) the overall similarity with the amino acid sequence in (a) is more than 85% More than %, genes with hyaluronidase activity. The invention successfully realizes the high-efficiency heterologous expression and purification of the obtained leech hyaluronidase by adopting the Pichia pastoris expression system. The leech hyaluronidase product prepared by recombination in the invention belongs to the pharmacologically active compound and can be used in medical fields such as treating brain, cardiovascular disease, ophthalmic disease, anti-tumor and drug diffusing agent. The invention lays a foundation for realizing the industrialized preparation and production of hyaluronidase derived from leeches.
Owner:JIANGNAN UNIV
MiRNA for restricting activity of hyaluronidase and application thereof
InactiveCN103013997ALow costNo residueAntipyreticGenetic material ingredientsOrganic solventNucleotide
The invention discloses miRNA for restricting activity of hyaluronidase and application thereof. The sequence is shown in SEQIDNo.1. The miRNA can be used for preparing a drug for restricting the activity of the hyaluronidase. The miRNA is small nucleotide which is specifically separated and extracted from natural plant, and is simple and feasible, and relatively low in cost. The hydrating solution disclosed by the invention can be stored at low temperature, is safe and free of pollution, and has no other residual organic solvents.
Owner:NANJING UNIV
Composition for inhibiting enzyme activity of hyaluronic acid and skin care product
ActiveCN111870558ASlow degradationGood inhibitory effectCosmetic preparationsToilet preparationsHyaluronan degradationMedicine
The invention provides a composition for inhibiting enzyme activity of hyaluronic acid. The composition comprises glutamic acid, theanine and mannose. The invention also provides a skin care product.The skin care product is characterized by comprising the composition for inhibiting enzyme activity of hyaluronic acid and the hyaluronic acid. The composition capable of inhibiting enzyme activity ofhyaluronic acid provided by the invention has an obvious inhibiting effect on the enzyme activity of hyaluronic acid, the enzyme activity of the hyaluronic acid can be effectively inhibited by the composition with low addition quantity, and the half inhibition dosage (IC50) for the enzyme activity of the hyaluronic acid can be as low as 0.17 mg / mL. The stability of a hyaluronic acid solution canalso be improved, and the degradation speed of the hyaluronic acid in a solution state is reduced. According to the skin care product provided by the invention, the composition for inhibiting the enzyme activity of hyaluronic acid can promote the exertion of the efficacy of the hyaluronic acid and improve the moisturizing effect of the hyaluronic acid.
Owner:BLOOMAGE BIOTECHNOLOGY CORP LTD
Agarwood extract with soothing and anti-allergic effects and its preparation method and application
ActiveCN105125446BHigh active ingredient extraction rateSimple and fast operationCosmetic preparationsToilet preparationsAdditive ingredientAllergy
Owner:山东山科美谷科技发展有限公司
Skin tightening eye mask
InactiveCN107456426AHas absorptionWith slow release functionCosmetic preparationsToilet preparationsWrinkle skinMedicine
The invention discloses an elastic firming eye mask, which contains 0.3-0.5 parts by weight of liposomes, wherein the liposomes include a weight ratio of: (3-5): (4-7): ( 1‑3): (2‑5) butanediol, water, peony root extract, iris extract. The eye mask of the present invention improves the damage to cells through the activity of scavenging free radicals, improves the ability of tissues to resist free radical oxidation, and then achieves the effect of anti-oxidation and delaying aging, and at the same time can inhibit the activity of hyaluronidase, and improve the moisturizing effect of the skin , so as to restore the elasticity of the skin, tighten the skin, and avoid accelerated aging of the eyes, causing dullness, fine lines and other phenomena.
Owner:FOSHAN SANSHUI DISTRICT JIAHUA CHEM RES INST GENERAL PARTNERSHIP
Research method for screening and extracting process of chamomile anti-asthma active ingredients
ActiveCN112763609AImprove extraction efficiencyIncrease productivityComponent separationBiotechnologyMedicinal herbs
The invention discloses a research method for a screening and extracting process of chamomile anti-asthma active ingredients, and relates to the technical field of chamomile processing. The method comprises the following steps: S01, carrying out clustering analysis on chamomile medicinal materials in different batches, and determining a suitable production place of chamomile; S02, determining optimal extraction conditions of a chamomile active part extraction process by taking dicaffeoylquinic acid content, extract yield and hyaluronidase activity as indexes; and S03, taking the two characteristic components of 3, 5-di-O-caffeoylquinic acid and 4, 5-di-O-caffeoylquinic acid as indexes, purifying the two characteristic components, and determining the optimal purification conditions of the purification process of the chamomile active site. Through the systematic analysis method, the anti-asthma active components in the chamomile are systematically extracted and produced, and through an optimal solution of an extraction and purification process of the anti-asthma active components, the extraction efficiency of the anti-asthma active components in the chamomile is improved, and the production efficiency is improved.
Owner:新疆医科大学第四附属医院
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