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Composition for inhibiting enzyme activity of hyaluronic acid and skin care product

A hyaluronidase and skin care technology, applied in the field of daily chemicals, can solve the problems of no hyaluronidase inhibitors, easy degradation of hyaluronic acid, etc., to achieve the effect of improving moisturizing effect, reducing degradation speed and improving stability

Active Publication Date: 2020-11-03
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem that hyaluronidase is easy to degrade hyaluronic acid due to the presence of hyaluronidase in the prior art, and there is no particularly effective hyaluronidase inhibitor used in cosmetics, the present invention provides a combination that inhibits hyaluronidase activity and skin care products comprising the composition inhibiting hyaluronidase activity

Method used

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  • Composition for inhibiting enzyme activity of hyaluronic acid and skin care product
  • Composition for inhibiting enzyme activity of hyaluronic acid and skin care product
  • Composition for inhibiting enzyme activity of hyaluronic acid and skin care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Add 100 mL of water into the dissolving tank, slowly add 5 g of L-glutamic acid, 2 g of theanine, and 0.5 g of mannose into the dissolving tank, stir to dissolve them all, and mix evenly to obtain a composition solution.

[0042] The composition solution was stirred at 80°C for 4-6 hours, condensed to a solid state with liquid nitrogen, and placed in a freeze dryer (Yaxing, LGJ-10N) for 24-48 hours of freeze-drying until the solvent was completely removed to obtain Composition powder for inhibiting hyaluronidase activity.

Embodiment 2-6

[0044] The difference between Example 2-Example 6 and Example 1 is that the amounts of glutamic acid, theanine, and mannose are different, and the specific parameters are shown in Table 1.

Embodiment 7

[0076] The preparation of embodiment 7 skin care products

[0077] Formulate skin care products, the preparation method is as follows:

[0078] (1) Add 0.5g sodium hyaluronate (molecular weight 1.5 million, batch number 1810195) into 50mL water, stir until completely dissolved;

[0079] (2) Add glutamic acid, theanine, mannose, preservatives, and functional ingredients to the mixture in step (1), stir to dissolve them all, and add water to make up the volume to 100mL;

[0080] (3) Adjust the pH to 6.5 with 0.1% NaOH solution to obtain a skin care product.

[0081] According to the above preparation method, the skin care products of Example 7-1 and Comparative Examples 7-1 to 7-8 were prepared according to the content of each raw material in the raw material composition comparison table in Table 4.

[0082] Wherein, in step (3) in Comparative Example 7-7, the pH was adjusted to 4.5 to obtain a skin care product.

[0083] In the step (3) of Comparative Examples 7-8, the pH wa...

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Abstract

The invention provides a composition for inhibiting enzyme activity of hyaluronic acid. The composition comprises glutamic acid, theanine and mannose. The invention also provides a skin care product.The skin care product is characterized by comprising the composition for inhibiting enzyme activity of hyaluronic acid and the hyaluronic acid. The composition capable of inhibiting enzyme activity ofhyaluronic acid provided by the invention has an obvious inhibiting effect on the enzyme activity of hyaluronic acid, the enzyme activity of the hyaluronic acid can be effectively inhibited by the composition with low addition quantity, and the half inhibition dosage (IC50) for the enzyme activity of the hyaluronic acid can be as low as 0.17 mg / mL. The stability of a hyaluronic acid solution canalso be improved, and the degradation speed of the hyaluronic acid in a solution state is reduced. According to the skin care product provided by the invention, the composition for inhibiting the enzyme activity of hyaluronic acid can promote the exertion of the efficacy of the hyaluronic acid and improve the moisturizing effect of the hyaluronic acid.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and in particular relates to a composition and a skin care product for inhibiting the activity of hyaluronidase. Background technique [0002] Hyaluronic acid (Hyaluronic Acid, HA) is a natural mucopolysaccharide formed by alternating units of D-glucuronic acid and N-acetylglucosamine in a straight chain. With its unique molecular structure and physical and chemical properties, hyaluronic acid shows a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating proteins, and promoting wound healing. More importantly, it has a special water-retaining effect and is the most moisturizing substance found in nature so far, known as the ideal natural moisturizing factor (NMF). [0003] Hyaluronic acid is a multifunctional matrix widely distributed in various parts of the human body. The maturation and aging process o...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/44A61Q19/00
CPCA61K8/60A61K8/44A61Q19/00A61K2800/5922A61K2800/782
Inventor 王静耿凤邵萌郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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