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Agarwood extract with soothing and anti-allergic effects and its preparation method and application

A technology of agarwood extract and efficacy, applied in the field of agarwood extract with soothing and anti-allergic effects and its preparation and application, to achieve the effects of scavenging free radicals, inhibiting the release of histamine, protecting structural integrity and barrier function

Active Publication Date: 2017-09-05
山东山科美谷科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The comprehensive utilization of agarwood is mainly concentrated in the aspect of medicine and health products, and the application of agarwood in cosmetics, especially as a soothing and anti-allergic active ingredient, has rarely been reported so far

Method used

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  • Agarwood extract with soothing and anti-allergic effects and its preparation method and application
  • Agarwood extract with soothing and anti-allergic effects and its preparation method and application
  • Agarwood extract with soothing and anti-allergic effects and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The preparation of embodiment 1 agarwood extract

[0062] Feeding according to the ratio of material to liquid is 1:20, that is, add 50g of agarwood powder and 1000mL of ethanol solution with a volume fraction of 95% in a round bottom flask, the particle size of the agarwood powder is 40 mesh, and the bottle mouth is connected with a stirring device and a condensation reflux device ; Heating and reflux extraction at 65°C for 180min; stop heating, cool to 35°C, centrifuge at 5000rpm for 10min, take the supernatant and filter it with diatomaceous earth; The liquid has no obvious ethanol smell, and the extract of agarwood extract is obtained; add the extract of agarwood extract and 1,3-butanediol according to the ratio of material to liquid 1:100, stir and dissolve at 25°C for 30min, and filter with a 0.8μm straight plate; measure the pH value and solid content , total sugar, the measurement results are: the pH value is 7.0, the solid content is 60%, and the total sugar is...

Embodiment 2

[0063] The preparation of embodiment 2 agarwood extract

[0064] The production process flow chart of the agarwood extract provided by the invention is as figure 1 As shown, the specific process is as follows:

[0065] Feeding according to the ratio of material to liquid is 1:10, that is, add 50g of agarwood powder and 500mL of ethanol solution with a volume fraction of 60% in a round bottom flask, the particle size of the agarwood powder is 20 mesh, and the bottle mouth is connected with a stirring device and a condensation reflux device ; Heated and refluxed at 50°C for 180min; stopped heating, cooled to 30°C, centrifuged at 4000rpm for 20min, took the supernatant and filtered it with diatomaceous earth; The liquid has no obvious ethanol smell, and the extract of agarwood extract is obtained; the extract of agarwood extract and propylene glycol are added according to the ratio of material to liquid 1:50, stirred and dissolved at 20°C for 30 minutes, and filtered with a 0.2 ...

Embodiment 3

[0066] The preparation of embodiment 3 agarwood extract

[0067] Feeding according to the ratio of material to liquid is 1:30, that is, add 50g of agarwood powder and 1500mL of ethanol solution with a volume fraction of 80% in a round bottom flask. ; Heating and reflux extraction at 70°C for 150min; stop heating, cool to 40°C, centrifuge at 4500rpm for 15min, take the supernatant for fine filtration on a filter plate, and filter with diatomaceous earth; take the filtrate, concentrate under reduced pressure at 45-55°C and 0.1MPa to The liquid has no obvious ethanol smell, and the extract of agarwood extract is obtained; the extract of agarwood extract and glycerin are added according to the ratio of solid to liquid at 1:80, stirred and dissolved at 30°C for 30min, and filtered with a 10μm straight plate; the pH value, solid content, and total sugar are measured, and the results are: : The pH value is 8.0, the solid content is 50%, and the total sugar is 15 mg / mL; heat preservat...

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Abstract

The invention discloses an eaglewood extract with allergy-relieving and anti-allergy effects, and a preparation method and application thereof. The method comprises the following steps: (1) grinding eaglewood, and then heating and extracting the eaglewood in an ethanol solution; (2) performing cooling and filtering, and extracting filter liquor for later use; (3) concentrating the filter liquor in the step (2) to obtain eaglewood extract concrete; (4) mixing and dissolving the eaglewood extract concrete in the step (3) and polyol, and performing filtering to obtain filter liquor namely the eaglewood extract with the allergy-relieving and anti-allergy effects. The method for preparing the eaglewood extract, provided by the invention, is simple and convenient to operate and suitable for large-scale production, and the purity of an obtained product is higher. The eaglewood extract provided by the invention has multiple effects of inhibiting the activity of hyaluronidase, scavenging free radicals, achieving anti-inflammation and anti-allergy, enhancing a skin barrier function and the like. The extract has an environmentally-friendly extraction mode, is healthy and safe, inhibits release of allergy mediators such as histamine, and can be widely applied to various cosmetics such as masks by serving as an active anti-allergy ingredient.

Description

technical field [0001] The invention relates to an agarwood extract with soothing and anti-allergy effects, a preparation method and application thereof. Background technique [0002] An allergic reaction is an abnormal or pathological reaction of the human body to an antigen. In the process of allergic reaction, the allergen (antigen) plays a direct role and is the external cause of the allergic reaction; while the body's immunity is low, and the oxidative damage of cells by a large number of free radicals is the internal cause of the allergic reaction. Skin allergy is a relatively common skin problem. With the increase in the use of cosmetics and other chemicals, environmental problems, the accelerated pace of life in modern society, and increased pressure, more and more people have sensitive skin. Coupled with some people's improper use of skin care products and other reasons, it is often easy to cause skin allergies, and allergic symptoms such as itching, scaling, redne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/84A61Q19/00A61Q19/08A61P37/08
CPCA61K8/97A61K2800/75A61K2800/782A61Q19/005A61Q19/08
Inventor 王领李天铎杨效登邢澍
Owner 山东山科美谷科技发展有限公司
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