Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gentian compound extract and preparation method and use thereof

The technology of extracting liquid and gentian is applied in the field of compound extracting liquid of gentian and its preparation, which can solve the problems of expensive equipment, difficult cleaning and high extraction temperature, and achieve the effects of reducing energy consumption and improving extraction efficiency.

Active Publication Date: 2018-11-16
GUANGDONG DIMEI NEW MATERIAL TECH CO LTD
View PDF4 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used extraction techniques include solvent extraction, ultrasonic extraction, microwave extraction, supercritical fluid extraction, etc. Among them, solvent extraction has problems such as high extraction temperature, low extraction rate, and high cost; The location and other requirements are high, and there are problems such as engineering equipment amplification; the microwave extraction method has limitations that are only suitable for thermally stable substances; the supercritical fluid extraction method has problems such as poor solubility of water-soluble components, expensive equipment, and difficult cleaning.
[0005] For example, the Chinese patent with application number 201810033550.1 discloses "a kind of gentian extract and its extraction process". Insoluble or water-insoluble ingredients such as gentianine increase the yield of active ingredients, but because microwave heating is only suitable for thermally stable substances during extraction, there are certain limitations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gentian compound extract and preparation method and use thereof
  • Gentian compound extract and preparation method and use thereof
  • Gentian compound extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Weigh dry 20g gentian root, 10g scutellaria baicalensis root, 5g centella asiatica, 5g flavescens root and 2g licorice root, grind into 150 mesh gentian root mixed powder with a pulverizer at high speed, and set aside; Gentian root mixed powder Add it to a mixed solvent of 20g propylene glycol and 50g deionized water and mix evenly. Put the gentian root mixture in a -10°C refrigerator to freeze for 2 hours, take it out and put it in 55°C distilled water to thaw for 2 hours, and cycle like this for 3 times; Then add citric acid to adjust the PH of Gentiana root extract to 5.5, place the extract in a water bath at 55°C, add 3g of cellulase, stir and extract for 2 hours, filter it roughly with 300-mesh gauze, and then filter it with a 0.45μm filter membrane , a yellow liquid was obtained.

Embodiment 2

[0064] Weigh dry 15g gentian root, 15g scutellaria baicalensis root, 3g centella asiatica, 8g flavescens root and 3g licorice root, grind into 200 mesh gentian root mixed powder with a pulverizer at high speed, and set aside; Gentian root mixed powder Add it to the mixed solvent of 15g butanediol and 55g deionized water and mix evenly. Put the gentian root mixture into the -10°C refrigerator for 2 hours, take it out and put it in 50°C distilled water to thaw for 2 hours, and cycle like this for 4 times Add citric acid to adjust the pH of the gentian root extract to 6.0, place the extract in a water bath at 55°C, add 2g of cellulase and 1g of pectinase, stir and extract for 3 hours, then add 1g of protease and stir for 1 hour, Then coarsely filter with 300-mesh gauze, and then finely filter with a 0.45 μm filter membrane to obtain a dark yellow liquid.

Embodiment 3

[0066] Weigh dry 25g gentian root, 10g baicalensis root, 10g centella asiatica, 6g flavescens root and 4g licorice root, grind into 250 mesh gentian root mixed powder with a pulverizer at high speed, and set aside; Gentian root mixed powder Add it to a mixed solvent of 10g propylene glycol and 80g deionized water and mix evenly. Put the gentian root mixture in a -10°C refrigerator to freeze for 2 hours, take it out and put it in 55°C distilled water to thaw for 2 hours, and cycle like this for 5 times; Then add citric acid to adjust the pH of Gentiana root extract to 6.5, place the extract in a water bath at 55°C, add 3g of cellulase and 1g of pectinase, stir and extract for 2 hours, then add 1g of protease to extract for 1 hour, and then use Coarsely filter with 300-mesh gauze, and then finely filter with a 0.45 μm filter membrane to obtain a dark yellow liquid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses gentian compound extract. The gentian compound extract is prepared from 10-25 parts by weight of gentian root, 5-20 parts by weight of radix scutellariae, 3-10 parts by weightof centella asiatica, 1-8 parts by weight of radix sophorae flavescentis, 1-5 parts by weight of licorice root, 1-5 parts by weight of a plant extract enzyme, 10-30 parts by weight of low molecular weight alcohol and 40-80 parts by weight of deionized water. The invention also provides a preparation method of the gentian compound extract. The preparation method comprises: raw material crushing, temperature difference method extraction, enzymatic hydrolysis extraction, enzyme inactivation treatment and extraction liquid filtration. The contents of the five raw materials and other components arecontrolled in the optimal range and have reasonable compatibility so that the inhibition rate of hyaluronidase activity can reach to 76%. The gentian compound extract can fast resist allergy and relieve itching to reduce patient's pain. The wall is broken through a temperature difference-enzymatic hydrolysis method so that the gentiopicroside content is 2180.5ppm and thus the extraction rate of the active ingredients is greatly improved, the problem that the traditional method easily causes viscous substance blocking in the filter in extraction is solved, the energy consumption and equipmentrequirements are reduced and large-scale production is feasible.

Description

technical field [0001] The invention relates to the technical field of natural product extraction, in particular to a gentian compound extract and a preparation method and application thereof. Background technique [0002] Skin allergy refers to abnormal specific immune responses such as physiological dysfunction or body damage when the skin is stimulated by an allergen. It is often accompanied by symptoms such as skin itching, redness, and scaling. There are currently four recognized anti-allergic and anti-itching ways: (1) isolate allergens; (2) improve skin protection function, reduce skin sensitivity by repairing or enhancing skin barrier protection function, and play an anti-allergic effect; (3) Inhibit the release of inflammatory factors, by inhibiting the generation or release of histamine, heparin and other mediators; (4) improve the skin's self-repair function, through the action of externally applied active substances, improve skin repair ability and weaken inflam...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61P17/04A61P37/08
CPCA61K8/9789A61K2800/782A61K2800/805A61P17/04A61P37/08A61Q19/00A61Q19/005
Inventor 宋天龙陈娟陶宏兵赵月美刘永龙黄小茉李良秋
Owner GUANGDONG DIMEI NEW MATERIAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com