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Glycyrrhiza glabra extract and preparation method and applications thereof

A technology for extracting and licorice glabra, applied in the field of licorice glabra extract and preparation thereof, can solve the problems of less comprehensive utilization, large safety risks, discount of drug efficacy, etc., and achieve comprehensive utilization of resources and product components. Clear, easy-to-use results

Inactive Publication Date: 2019-04-02
广州诗美化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high market price of glabridin, there are relatively many studies on extracting glabridin from Glycyrrhiza glabra, but relatively few comprehensive utilizations.
Most of the other components are often discarded as secondary components along with the dregs, resulting in a great waste of resources
[0004] There are also reports about the comprehensive utilization of Glycyrrhiza glabra on the market. However, the existing reports are mainly extracted by traditional methods such as steaming, water extraction and alcohol precipitation. Glycyrrhiza polysaccharides and dipotassium glycyrrhizinate ingredients with anti-allergic properties are denatured and degraded during the drying and heating extraction process of the medicinal materials, resulting in reduced efficacy
In addition, flavonoids represented by glabridin are insoluble in water but soluble in organic solvents. Therefore, organic solvents are commonly used to extract the active ingredients of glabra. The most obvious disadvantage of this type of method is the residual solvent, which leads to There are greater safety risks in use, such as allergies, skin toxicity, etc.

Method used

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  • Glycyrrhiza glabra extract and preparation method and applications thereof
  • Glycyrrhiza glabra extract and preparation method and applications thereof
  • Glycyrrhiza glabra extract and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] A kind of licorice glabra extract is prepared by the following method:

[0061] The roots and rhizomes of 10kg of fresh licorice (Glycyrrhiza glabra L.) were pulverized with a JMW-200 horizontal colloid mill (Shanghai Liangyi Pump Industry) (the fixed rotation distance was 0.3mm, and the rotating speed was 2900rpm) to obtain a homogeneous pulverized product. Add 200kg of butanediol to the homogenized pulverized matter, extract with an ultrasonic extractor at 60°C and an ultrasonic frequency of 20KHz for 60 minutes, extract once in total, and then pass the obtained ultrasonic extract through a three-legged centrifuge at 4000 rpm Centrifuge to remove medicinal residues, use 500nm ceramic membrane separation (continuous membrane separation) to remove macromolecular substances such as pectin resin, take the membrane clear liquid, and then concentrate it to a relative density of 1.12 (25°C) with an ultrafiltration membrane with a molecular weight cut-off of 3000Da ) to obtai...

Embodiment 2

[0063] A kind of licorice glabra extract is prepared by the following method:

[0064] The roots and rhizomes of 10kg of fresh licorice (Glycyrrhiza glabra L.) were pulverized with a JMW-200 horizontal colloid mill (the fixed rotation distance was 0.1mm, and the rotation speed was 1500rpm) to obtain a homogeneous pulverized product; to the homogeneous pulverized product, add 300kg70% butanediol aqueous solution (W / W), extracted with an ultrasonic extractor at 40°C and an ultrasonic frequency of 30KHz for 90 minutes, extracted once in total, and then passed the obtained ultrasonic extraction solution through a 4000 rpm three-legged centrifuge Centrifuge to remove medicinal residues, use 800nm ​​ceramic membrane to separate and remove macromolecular substances such as pectin resin, take the membrane clear liquid, and then concentrate it to a relative density of 1.13 (25°C) with an ultrafiltration membrane with a molecular weight cut-off of 5000Da to obtain Guangguo Licorice extr...

Embodiment 3

[0066] A kind of licorice glabra extract is prepared by the following method:

[0067] The root and rhizome of 10kg of fresh licorice glabra (Glycyrrhiza glabra L.) is pulverized with a JMW-200 horizontal colloid mill (fixed rotation distance is 0.2mm, rotating speed 2000rpm) to obtain a homogeneous pulverized product; to the homogeneous pulverized product, add 150kg30% butanediol aqueous solution (W / W), extracted with an ultrasonic extractor for 30 minutes at 50°C and an ultrasonic frequency of 60KHz, extracted once in total, and then passed the obtained ultrasonic extraction solution through a 6000 rpm three-legged centrifuge Centrifuge to remove medicinal residues, use a 1000nm ceramic membrane to separate and remove macromolecular substances such as pectin resin, take the supernatant, and then use ultrafiltration with a molecular weight cut-off of 10,000Da to concentrate to a relative density of 1.10 (25°C) to obtain Glycyrrhiza glabra extract thing.

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Abstract

The invention discloses a glycyrrhiza glabra extract and a preparation method and applications thereof. The method comprises the following steps: (1) pulverizing fresh glycyrrhiza glabra with a colloid mill to obtain a homogenate pulverized product; and (2) adding an extraction solvent to the homogenate pulverized product obtained in the step (1), performing ultrasonic extraction to obtain an ultrasonic extractive liquid, and then subjecting the ultrasonic extractive liquid to separation and concentration so as to obtain the glycyrrhiza glabra extract. The extraction solvent is an aqueous solution of butanediol or butanediol. The method of the invention is simple in process operation and is easy to realize industrial production. The obtained glycyrrhiza glabra extract contains glycyrrhizaflavonoids, glycyrrhizin and glycyrrhiza polysaccharide, is rich in active ingredients in fresh plants, has obvious inhibition on tyrosinase activity and inhibition on hyaluronidase activity, and is suitable for whitening, anti-inflammatory and anti-allergic cosmetics.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a licorice glabra extract and a preparation method and application thereof. Background technique [0002] Licorice is one of the commonly used traditional Chinese medicine varieties in my country, widely used in medicine, tobacco, food, brewing and cosmetics and other fields. In the Chinese medicine industry, there is a saying of "ten directions and nine herbs", which shows that licorice is widely used in medicine. Glycyrrhiza glabra, a type of licorice, is the root and rhizome of Glycyrrhiza glabra L. It contains glycyrrhizin and glycyrrhizin. It is different from other licorice species in that these two characteristic components have a higher content, and it has been listed as licorice since ancient times. The best of the best. Because Glycyrrhizin and Glycyrrhizin have antioxidant activity, strong inhibition of tyrosinase, and the fun...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K9/06A61K47/38A61P29/00A61P31/04A61P37/08A61K8/9789A61Q17/00A61Q19/02A61Q19/00
CPCA61K36/484A61K8/9789A61K9/06A61K47/38A61K2236/15A61K2236/333A61K2236/53A61K2800/782A61K2800/82A61P29/00A61P31/04A61P37/08A61Q17/005A61Q19/005A61Q19/02
Inventor 刘明富
Owner 广州诗美化妆品有限公司
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