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57 results about "Escherichia coli infection" patented technology
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Infections with bacteria of the species Escherichia coli.
Echinacea extract and preparation method of echinacea extract
ActiveCN102716164AHigh extraction rateSynergisticAntibacterial agentsPeptide/protein ingredientsBiotechnologyMedicinal herbs
The invention relates to an echinacea extract and a preparation method of the echinacea extract. The echinacea extract provided by the invention is obtained through carrying out twice extraction on echinacea medicinal materials by alkaline ethanol solution and lysozyme; and in the product, the polysaccharide content is greater than or equal to 21.50 percent, the polyphenol content is greater than or equal to 8.10 percent, and the chicoric acid content is greater than equal to 5.00 percent. Because the polyphenol content and the chicoric acid content of the echinacea extract are obviously increased, the echinacea extract is prepared into ordinary preparations including powder or oral liquid and the like, and the curative effect is greatly improved. In a compound preparation processed by the echinacea extract and bacteriolysant according to a consumption ratio being 3:1, active ingredients of echinacea and lysozyme totally account for 20 percent, wherein the consumption ratio of the echinacea extract to the lysozyme is (4-1):1, auxiliary materials of cane sugar account for 64 percent, and dextrin accounts for 16 percent. The compound preparation has the functions of improving the immunity of live stock and realizing the sterilization and antivirus functions, and can be used as medicine for preventing and treating animal diseases, particularly chicken diseases caused by escherichia coli infection.
Owner:QILU ANIMAL HEALTH PROD
Compound composition containing plumbago zeylanica for treating livestock and poultry escherichia coli infection diseases
InactiveCN103301463AReverse drug resistanceGood treatment effectAntibacterial agentsDigestive systemTreatment effectEconomic benefits
The invention relates to a compound composition containing plumbago zeylanica for treating livestock and poultry escherichia coli infection diseases. The compound composition is prepared from the following materials in parts by weight: 3-30 parts of antibacterial drug, and 5-200 parts of plumbago zeylanica. The materials are prepared into powder, tablets, oral liquid or granules after being evenly mixed, and the compound composition is added to livestock and poultry feeds to feed according to the feed adding amount of 0.1-7 g / kg; and the tolerance of bacteria on the antibacterial drug can be changed over. Thus, the treatment effect of the antibacterial drug is improved; the drug cost is greatly reduced; and higher economic benefits are created for farmers.
Owner:广西南宁市桃源兽药厂
Method for prevention and treatment of escherichia coli infections using a bacteriophage with broad antibacterial spectrum against escherichia coli
ActiveUS20150322409A1Strong specificityLess side effectsAntibacterial agentsBiocideStructural proteinBacteriophage
The present invention relates to a composition comprising the bacteriophage EK88P-1 isolated from the nature and having a broad antibacterial spectrum against E. coli as an active ingredient, and a method for preventing and treating E. coli infections using the said composition. The bacteriophage EK88P-1, the active ingredient of the composition of the present invention, has a broad antibacterial spectrum against E. coli and has the genome characteristically composed of the partial nucleotide sequences represented by SEQ. ID. NO: 1˜NO: 25, and also characterized by the bacteriophage belonging to the Myoviridae family according to the morphology that is composed of the major structural proteins in the sizes of approximately 49 kDa, 53 kDa, 94 kDa, and 103 kDa.
Owner:INTRON BIOTECHNOLOGY INC
Nitrogen-heterocycle-containing artemisinin derivative and preparation method thereof
InactiveCN105503898AIncreased sensitivityStrong synergistic antibacterial effectAntibacterial agentsOrganic active ingredientsNitrogenArtemisinin
The present invention discloses a nitrogen-heterocycle-containing artemisinin derivative and a preparation method thereof, the derivative is a compound of a formula I, and X is imidazolyl, thiazolyl, oxazolyl or thiazolidinyl. The present invention also discloses use of the derivative in resisting Escherichia coli infection, and especially, the derivative shows a very strong synergistic antibacterial effect on Escherichia coli by combination with an artemisinin drug.
Owner:ARMY MEDICAL UNIV
Breeding method of new disease-resistance large white pig strain
InactiveCN106973854AEnhance immune responseReduce morbidityAnimal feeding stuffBiological testingInterleukin 6Lean meat
The invention discloses a breeding method of a new disease-resistance large white pig strain. The method includes the following steps that 1, a feed adding method is adopted to conduct an Escherichia coli infection experiment on weaned piglets of a core group in large white pigs, and an Escherichia coli resistant breeding basic group in the large white pigs is established; 2, concentration determination is conducted on cytokines of interleukin 1beta, interleukin 4, interleukin 6, interleukin 8, interleukin 10, transforming growth factor beta, tumor necrosis factor alpha and interferon gamma of an Escherichia coli resistant population in the basic group; reproductive performances are detected and selected, growth speeds, lean meat ratios and carcass quality characters, and a first generation is established; 3, a group subculture selective breeding method and a molecular-marker-assisted selection method are adopted. In this way, by the adoption of the breeding method of the new disease-resistance large white pig strain, after four to five generations, a vested breeding target is achieved gradually, a new-strain core group is established, and the morbidity of piglet diarrheal diseases is expected to be reduced.
Owner:TAICANG JINZHU AGRI DEV
Fermented Chinese herbal preparation capable of preventing escherichia coli infection in broiler chickens and application of fermented Chinese herbal preparation
ActiveCN104524453ANon-toxicNo drug residueAntibacterial agentsAnimal feeding stuffHerbal preparationsAdditive ingredient
Owner:山东宝来利来生物工程股份有限公司
Breeding method of new Berkshire pig disease-resistant variety
InactiveCN107494422AImprove reproductive performanceSimple structureAnimal husbandryDiseaseLean meat
The invention relates to a breeding method of a new Berkshire pig disease-resistant variety. The breeding method comprises the steps that firstly, weaned piglets of a Berkshire pig core group are subjected to Escherichia coli infection experiments by adopting a feed adding method, according to a phenotype identification result, a Berkshire pig Escherichia coli disease-resistant breeding base group is established; secondly, the base group is subjected to molecule breeding with general resistance to diseases by using a proprietary technology obtained in the early stage, meanwhile characters such as breeding performance, growing speed, lean meat percentage and carcass quality are detected and selected, and a first generation is built; thirdly, a group continuous progeny breeding and molecular marker assisted selection method is adopted, after four to five generations, an established breeding aim is achieved step by step, and a new variety core group is established. The new Berkshire pig disease-resistant variety has the advantages of resistance to weaned piglet diarrheal diseases, high stress resistance, high environmental adaptability and the like, and can further provide guidance for disease-resistant breeding and new variety selection and breeding of other pig varieties.
Owner:YANGZHOU UNIV
Compound composition for treating livestock escherichia coli infection disease
ActiveCN103908670AReverse drug resistanceGood treatment effectAntibacterial agentsCyclic peptide ingredientsTreatment effectAntibacterial agent
Owner:GUANGXI UNIV
Compound coneflower preparation preparation method
The invention provides a compound coneflower preparation, wherein a use ratio of effective components such as a coneflower extract and lysozyme is 3:1, the total content of the coneflower extract and the lysozyme is 25%, and contents of auxiliary materials such as sucrose and dextrin are respectively 60% and 15%. According to the present invention, the selected coneflower extract is obtained by extracting a coneflower herb with an alkaline ethanol solution and lysozyme; the polysaccharide content exceeds 20%, the polyphenol content exceeds 8%, and the chicoric acid content exceeds 5%; and the composite preparation has functions of animal immunity improving, anti-bacterial and anti-virus, and can be used for preparation of drugs for prevention and treatment of animal diseases, especially prevention and treatment of chicken diseases caused by escherichia coli infection.
Owner:QINGDAO KDN BIOTECH
Compound echinacea purpurea preparation and preparation method and application thereof
ActiveCN102772790AImprove immunityAnti-inflammatoryAntibacterial agentsPeptide/protein ingredientsAnti virusSaccharum
The invention discloses a compound echinacea purpurea preparation. The dose ratio of an echinacea purpurea extract as an effective component to lysozyme is (4-1):1, the dosage of the echinacea purpurea extract and the lysozyme is 20% in total, and the ajudvants contains 64% of saccharose and 16% of dextrin. The echinacea purpurea extract selected by the invention is obtained by extracting echinacea purpurea medicinal material by alkaline ethanol solution and lysozyme for two times, wherein the content of polysaccharide is not less than 21.5%, the content of polyphenol is not less than 8.10% and the content of chicoric acid is not less than 5.00%. The compound preparation provided by the invention has the effects of improving animal immunity, antibiosis and anti-virus, thereby being capable of being taken as the medicine for preventing and treating the animal diseases, in particular to the chicken diseases caused by escherichia coli infections.
Owner:QILU ANIMAL HEALTH PROD +1
Compound neomycin sulfate oral liquid for treating severe diarrhea of poultry and preparation method thereof
InactiveCN102885848AReasonable compositionHigh clarityAntibacterial agentsOrganic active ingredientsBerberine hydrochlorideSevere diarrhea
The invention discloses compound neomycin sulfate oral liquid for treating severe diarrhea of poultry. The oral liquid comprises the following components in parts by weight: 8 to 15 parts of neomycin sulfate, 3 to 6 parts of berberine hydrochloride, 1 to 3 parts of lactate TMP, 10 to 20 parts of injection astragalus polysaccharide, 2 to 4 parts of levamisole hydrochloride, 5 to 15 parts of acetaminophen, and 60 to 80 parts of injection water. The compound neomycin sulfate oral liquid for treating the severe diarrhea of the poultry is applied to the poultry, and is used for Gram-negative bacteria-induced gastrointestinal severe infection of the poultry and used for treating enteritis and diarrhea of the poultry. By using the oral liquid for treating escherichia coli infection and unknown severe diarrhea of the poultry, the significant efficiency is 94.1 percent, and the effective rate is 99.8 percent. The oral liquid is reasonable in formula compatibility, high in defecation level, low in dust content, low in pollution, high in oral bioavailability and convenient for industrialization.
Owner:TIANJIN BIJIA PHARMA CO LTD
High-efficient expression of recombined swine IL 22 in escherichia coli and its application
ActiveCN108070599AProcess stabilityFree from harmAntibacterial agentsAntimycoticsBiotechnologyPurification methods
The invention discloses a gene for encoding recombined swine IL 22. The invention further discloses a recombined expression carrier containing a recombined gene, a transgene cell system, a transgene recombined bacterial and a host cell. The invention further discloses a recombined swine IL 22 and its extraction and purification method. The invention further discloses an application of recombined plasmid pET-32a(+)-PIL-22, recombined strain and recombined protein in anti-apoptosis and prevention of escherichia coli infection. The carrier pET-32a(+) of the expression recombined swine IL 22 structured in the invention contains His label, the recombined swine IL 22 protein extracted from escherichia coli is connected with the His label; through a His pillar, the highly purified recombined swine IL 22 protein is acquired; the expression output of the recombined swine IL 22 protein is counted through Quantity One software, the purity is up to 95.7%.
Owner:NANJING AGRICULTURAL UNIVERSITY
Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry
InactiveCN105395835AResidue reductionReduce usageAntibacterial agentsPowder deliveryPoultry diseaseSide effect
The invention relates to a traditional Chinese medicine composition preventing and treating escherichia coli infection in the brooding stage of poultry. According to the dialectical characteristics of escherichia coli infection in the brooding stage of poultry, ophiopogon japonicus for nourishing yin and generating body fluid and rehmannia roots for cooling blood and nourishing yin jointly serve as monarch medicine, radix berberidis for purging intense heat and removing toxic matter serves as minister medicine, and astragalus for benefiting qi and strengthening superficies, atractylodes for strengthening the spleen and benefiting qi and licorice for tonifying the spleen and benefiting qi together serve as assisting and guiding medicine. On one hand, the cold properties of the monarch and minister medicine are relieved, and on the other hand, the medicine has the functions of consolidating the basis and can meet the requirement of effectively preventing and controlling escherichia coli infection on the premise that the internal organs of young poultry are immature in the growth and development stage of the young poultry. As shown by a larger amount of clinical application to poultry diseases, the traditional Chinese medicine composition has the advantages that the effect is exact, toxic and side effects are avoided, and medicine residuals are avoided.
Owner:青岛汉河动植物药业有限公司
Pure natural plant component additive for relieving diarrhea of weaned piglets and improving intestinal health of weaned piglets
InactiveCN108210586AImprove growth performanceRelieve diarrheaDigestive systemAnimal feeding stuffTraditional medicinePlant Components
The invention provides a compound plant extract for relieving diarrhea of weaned piglets and improving intestinal health of the weaned piglets. The extract is prepared from the following components inparts by mass: 30-35 parts of flos lonicerae extract, 30-35 parts of fructus forsythiae extract, 10-20 parts of radix scutellariae extract and 20-30 parts of rhizoma coptidis extract. In combinationwith the research progress of the efficacy of plant extracts and the experience of application of the plant extracts to pig production, the compound plant extract product (PEM) is prepared from the plant extracts prepared from the selected flos lonicerae extract, fructus forsythiae extract, radix scutellariae extract and rhizoma coptidis extract in a certain ratio. The pig feeding experiment proves that with addition of the compound plant extract product to the diet, diarrhea of the piglets can be effectively reduced, the growth performance of the piglets is improved, and immune stress causedby escherichia coli infection is relieved.
Owner:CHINA AGRI UNIV
Therapeutic monoclonal antibody for resisting escherichia coli infection, hybridoma cell strain generating monoclonal antibody and use of therapeutic monoclonal antibody
The invention discloses a therapeutic monoclonal antibody for resisting escherichia coli infection, a hybridoma cell strain for generating the monoclonal antibody and use of the therapeutic monoclonal antibody. The invention also discloses an epitope polypeptide of MraY protein which is specifically combined with the monoclonal antibody. The monoclonal antibody disclosed by the invention is generated by a hybridoma cell named M-H11 and has specificity for polypeptide which is encoded by a nucleotide sequence shown in SEQ ID No.1. The invention provides a novel monoclonal antibody for resisting escherichia coli, and a hybridoma cell strain generating the monoclonal antibody; the epitope and in vitro antibacterial properties and the in-vivo treatment effect are identified; the invention has a great significance in application of the therapeutic monoclonal antibody for preventing and treating escherichia coli infection and also lays a foundation for treatment of gram-negative bacterial infection and intensive study of bacterial ghost vaccines.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Yolk antibody for preventing and treating colibacillosis, preparation method for yolk antibody and feed additive
ActiveCN102532311AImprove protection efficiencyImproving immunogenicityAntibacterial agentsEgg immunoglobulinsESCHERICHIA COLI ANTIGENYolk
The invention belongs to the technical field of veterinary biology, and in particular relates to a yolk antibody for preventing and treating colibacillosis and a preparation method and application of the yolk antibody. The escherichia coli yolk antibody is prepared by using a mixed solution of extracted avian pathogenic escherichia coli O78 outer membrane protein and pilin as antigen immune chicken; and experiments show that the yolk antibody is safe and efficient and has a good protective effect on homogenous and multiple alien escherichia coli. The yolk antibody can be used for preventing and treating multi-serotype colibacillosis, and can also be used as an additive of health-care products, food and feed or used for preparing preparations for detecting related diseases caused by escherichia coli infection.
Owner:兆丰华生物科技(南京)有限公司 +2
Multimeric mannosides, a process for preparing the same and their uses as a drug
The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:
Owner:CENT NAT DE LA RECHERCHE SCI +4
Herbal veterinary medicine for preventing and treating chicken heat-toxin symptoms, and preparation method and application thereof
InactiveCN103893523AReduce wasteImprove efficacyAntibacterial agentsGranular deliveryMedicinal herbsBaical Skullcap Root
The invention discloses a herbal veterinary medicine for preventing and treating chicken heat-toxin symptoms caused by Escherichia coli infection. The herbal veterinary medicine comprises the following raw materials: on the basis of the amount of crude drugs, 30 to 90 g of gypsum, 3 to 20 g of honeysuckle flower, 2 to 30 g of figwort root, 2 to 15 parts of baical skullcap root, 2 to 15 g of raw rehmannia root, 2 to 15 g of weeping forsythia capsule, 2 to 15 g of cape jasmine, 2 to 15 g of Chinese gentian, 2 to 30 g of Gueldenstaedtia multiflora Bunge., 2 to 40 g of isatis root, 2 to 15 g of common anemarrhena rhizome and 2 to 15 g of dwarf lilyturf tuber. The herbal veterinary medicine is a granule which further comprises an excipient. A preparation method for the summer-heat-removing granule comprises the following steps: (1) extracting the above-mentioned raw materials so as to prepare extract powder; (2) adding the excipient and carrying out uniform mixing; and (3) successively carrying out granulation, drying and split charging so as to obtain the finished granule. The granule provided by the invention is named as summer-heat-removing granule, is capable of clearing heat, removing toxins, nourishing yin and checking dysentery and has the advantages of a substantial effect, convenience in administration and no toxic and side effects.
Owner:QINGDAO VLAND BIOTECH INC
Granule for treatment of heat toxin symptom caused by chicken escherichia coli infection and preparation method thereof
ActiveCN102895503AReduce wasteImprove efficacyAntibacterial agentsGranular deliverySide effectBaical Skullcap Root
The present invention discloses a granule for treatment of heat toxin symptom caused by chicken escherichia coli infection. The raw material ratio by crude medicines includes: 30-90g of gypsum, 3-20g of honeysuckle, 2-30g of figwort root, 2-15g of baical skullcap root, 2-15g of dried radix rehmannia, 2-15g of fructus forsythiae, 2-15g of fruit of cape jasmine, 2-15g of gentiana scabra bunge, 2-30g of bunge corydalis herb, 2-40g of isatis root, 2-15g of rhizoma anemarrhena, and 2-15g of radix ophiopogonis. The granule also includes an excipient. The preparation method of the granule includes: (1) extracting the prescription medicine to make extract powder; (2) adding the excipient and mixing; and (3) granulating, drying and packaging to get finished products. The granule of the present invention has a trade name of clearing and releasing granule, has the effect of clearing heat and detoxifying, is significant in effects and easy to take, and has no toxic side effects.
Owner:QINGDAO VLAND BIOTECH INC +1
Application of antibacterial peptide in in-vitro inhibition of Escherichia coli
ActiveCN111658759AAvoid survivalPowerful killAntibacterial agentsOrganic active ingredientsPharmaceutical SubstancesAmino acid
The invention belongs to the field of cell biology, and particularly relates to an application of an antibacterial peptide in the in-vitro inhibition of Escherichia coli. The antibacterial peptide selected by the invention is a natural antibacterial peptide Esculentin-1A, and the amino acid sequence information of the antibacterial peptide Esculentin-1A is shown as SEQ ID NO.1. In the research process, it is found that the antibacterial peptide Esculentin-1A and citric acid are mixed according to a mass ratio of (7-10):(2-5), and in-vitro tests prove that the inhibition of the mixture on Escherichia coli reaches 99% or more. The antibacterial peptide and citric acid are mixed for use for the first time, and a new research and development direction is provided for the development of drugs related to the treatment of symptoms such as cholecystitis and ovaritis caused by Escherichia coli infection.
Owner:广州颜如玉生物科技有限公司
Method for preparing livestock and birds raising product camellia seed triterpenoid saponin additive high purity raw powder
InactiveCN101167528AIncrease pay ratioGrowth inhibitionAnimal feeding stuffAccessory food factorsDiseaseAntibiotic Y
The invention relates to a process for preparing high purity raw powder of camellia seed triterpenoid saponin additive of livestock and poultry nourishing products, which belongs to the technical field of the process for preparing the livestock and poultry nourishing products. The invention aims to solve the technical problems of providing the process for preparing the high purity raw powder of the camellia seed triterpenoid saponin additive of the livestock and poultry nourishing products. The technical schemes which solves the technical problems are that the invention comprises the steps of the preparation of degreasing camellia seed power, the preparation of camellia seed triterpenoid saponin additive extract, the preparation of camellia seed triterpenoid saponin additive concentrated extract, the preparation of camellia seed triterpenoid saponin additive tobacco extract, column chromatography and drying. The invention is used to prepare the raw powder of camellia seed triterpenoid saponin additive of livestock and poultry nourishing products and is used as an addition agent of livestock and poultry feeds and drugs, the livestock and poultry nourishing products which contain antibiotics are replaced, and the purity of the raw powder is high. The beneficial effects are that the invention is capable of inhibiting the growth of bacillus coli and salmonella, is capable of treating diseases such as yellow scour of newborn piglets, white diarrhea, white diarrhea, typhoid fever, escherichia coli infection and salpingitis and the like, thereby adding the survival rate of piglets and the daily increase, and reducing the diarrhea rate.
Owner:任丽
Traditional Chinese veterinary medicinal compound composition for preventing and treating serious Escherichia coli infection of livestock and poultry, and preparation method thereof
InactiveCN105748689AImprove efficacyIncrease usageAntibacterial agentsOrganic active ingredientsDiseaseChlorogenic acid
The invention belongs to the technical field of veterinary medicines, and concretely relates to a traditional Chinese veterinary medicinal compound composition for preventing and treating serious Escherichia coli infection of livestock and poultry, and a preparation method thereof. The traditional Chinese veterinary medicinal compound composition for preventing and treating serious Escherichia coli infection of livestock and poultry comprises poplar flower, chlorogenic acid, natural indigo, Amur Corktree Bark, Agrimonia pilosa Ledeb., Meadowrue Root and Rhizome, Weeping Forsythia and purple daisy. The traditional Chinese veterinary medicinal compound composition has no medicine resistance problem, is safe and environmentally-friendly, has the efficacy of clearing heat, detoxifying and preventing bacteria and toxins, and is especially suitable for treating livestock and poultry enteritis, dysentery and other intestinal diseases induced by serious Escherichia coli infection, and the preparation method is simple and reduces the medication cost of the animal husbandry production.
Owner:天津德瑞祥科技有限公司
Method for treating animal escherichia coli infected diseases
InactiveCN103933109AReverse drug resistanceGood treatment effectAntibacterial agentsAnimal feeding stuffBacteroidesTreatment effect
Owner:GUANGXI UNIV
Goat F17 escherichia coli infection resisting gene screening method
PendingCN109797198AImprove the success rate of attacking poisonStrong targetingMicrobiological testing/measurementProteomicsDisease resistantGenetic screening method
The invention discloses a goat F17 escherichia coli infection resisting gene screening method which includes the steps: F17 escherichia coli infection diseased lamb and disease-resistant lamb screening and spleen and intestinal canal content sample acquisition; F17 escherichia coli infection diseased lamb and disease-resistant lamb spleen sample high-throughput sequencing; F17 escherichia coli infection diseased lamb and disease-resistant lamb spleen transcriptomics comparative analysis; F17 escherichia coli infection resisting gene (circRNA) screening and identifying. The goat F17 escherichiacoli infection resisting gene screening method is used for screening F17 escherichia coli infection resisting genes (circRNA) from disease-resistant lamb spleens in a targeted manner, is high in accuracy and pertinence and saves time.
Owner:YANGZHOU UNIV
Method for treating Escherichia coli infection diseases by using creat and antibacterial agents
InactiveCN103933088AReverse drug resistanceGood treatment effectAntibacterial agentsClimate change adaptationDiseaseBacteroides
Owner:GUANGXI UNIV
Granule for treatment of heat toxin symptom caused by chicken escherichia coli infection and preparation method thereof
ActiveCN102895503BReduce wasteImprove efficacyAntibacterial agentsGranular deliveryBiotechnologyMedicinal herbs
The present invention discloses a granule for treatment of heat toxin symptom caused by chicken escherichia coli infection. The raw material ratio by crude medicines includes: 30-90g of gypsum, 3-20g of honeysuckle, 2-30g of figwort root, 2-15g of baical skullcap root, 2-15g of dried radix rehmannia, 2-15g of fructus forsythiae, 2-15g of fruit of cape jasmine, 2-15g of gentiana scabra bunge, 2-30g of bunge corydalis herb, 2-40g of isatis root, 2-15g of rhizoma anemarrhena, and 2-15g of radix ophiopogonis. The granule also includes an excipient. The preparation method of the granule includes: (1) extracting the prescription medicine to make extract powder; (2) adding the excipient and mixing; and (3) granulating, drying and packaging to get finished products. The granule of the present invention has a trade name of clearing and releasing granule, has the effect of clearing heat and detoxifying, is significant in effects and easy to take, and has no toxic side effects.
Owner:QINGDAO VLAND BIOTECH INC +1
IncRNA marker related to bacterial diarrhea resistance of piglets and application of IncRNA marker
InactiveCN113832235AAntibacterial agentsMicrobiological testing/measurementBiotechnologyBacteroides suis
The invention relates to an IncRNA marker related to bacterial diarrhea resistance of piglets and application of the IncRNA marker. According to the IncRNA marker and the application thereof, a key candidate lncRNA-FUT3-AS1 for Escherichia coli F18 infection regulation is screened through omics sequencing, the sequence is SEQ ID NO: 1, and on the basis, deep analysis is carried out around the function and regulation mechanism of the FUT3-AS1 in the research; firstly, qPCR and Northern blot technologies are used for detecting the expression difference condition of the FUT3-AS1 in duodenums of F18 Escherichia coli sensitive and resistant weaned piglets of Meishan pigs and Sutai pigs, lncRNA-FUT3-AS1-silenced pig small intestine epithelial cells are successfully established, and the interference efficiency reaches 68%; and a series of detection means such as bacterial counting, Gram's staining, scanning electron microscopy and indirect immunofluorescence find that the adhesion capability of F18 Escherichia coli to IPEC-J2 cells can be remarkably lowered by silencing lncRNA-FUT3-AS1. Therefore, the lncRNA-FUT3-AS1 plays an important resistance regulation function in a process of resisting F18 Escherichia coli infection of the weaned piglets, the adhesion ability of the small intestine epithelial cells to the F18 Escherichia coli is lowered by down-regulating an expression level of the lncRNA-FUT3-AS1, and the resistance ability of the piglets to the F18 Escherichia coli infection is favorably improved.
Owner:YANGZHOU UNIV
Echinacea extract and preparation method of echinacea extract
The invention relates to an echinacea extract and a preparation method of the echinacea extract. The echinacea extract provided by the invention is obtained through carrying out twice extraction on echinacea medicinal materials by alkaline ethanol solution and lysozyme; and in the product, the polysaccharide content is greater than or equal to 21.50 percent, the polyphenol content is greater than or equal to 8.10 percent, and the chicoric acid content is greater than equal to 5.00 percent. Because the polyphenol content and the chicoric acid content of the echinacea extract are obviously increased, the echinacea extract is prepared into ordinary preparations including powder or oral liquid and the like, and the curative effect is greatly improved. In a compound preparation processed by the echinacea extract and bacteriolysant according to a consumption ratio being 3:1, active ingredients of echinacea and lysozyme totally account for 20 percent, wherein the consumption ratio of the echinacea extract to the lysozyme is (4-1):1, auxiliary materials of cane sugar account for 64 percent, and dextrin accounts for 16 percent. The compound preparation has the functions of improving the immunity of live stock and realizing the sterilization and antivirus functions, and can be used as medicine for preventing and treating animal diseases, particularly chicken diseases caused by escherichia coli infection.
Owner:QILU ANIMAL HEALTH PROD
Composition for treating chicken escherichia coli infection and preparation method thereof
InactiveCN101966186AEfficient killingDelay drug resistanceAntibacterial agentsInorganic non-active ingredientsEtiologyBacteroides
The invention discloses a composition for treating chicken escherichia coli infection and a preparation method thereof, and aims to provide a composition for treating chicken escherichia coli infection and treating the root cause and symptoms of disease and a preparation method. The composition comprises the following components in percentage by weight: 5 to 15 percent of amoxicillin, 3 to 10 percent of ofloxacin, 3 to 10 percent of taurine, 5 percent of anhydrous sodium carbonate and the balance of anhydrous dextrose. The amoxicillin and the ofloxacin adopted in the composition can effectively kill escherichia coli aiming at etiology; the combination of the amoxicillin and the ofloxacin can reduce the probability of medicament resistance of the escherichia coli and improve the sensitivity, and also has good effect on other bacterial diseases secondarily infected by the escherichia coli; the taurine with anti-inflammatory effect has the effect of quickly diminishing inflammation caused by the escherichia coli; and the anhydrous sodium carbonate is used as a co-solvent so that the composition can be fully dissolved in water and is convenient to use. The medicaments are used together so that the composition can effectively resist etiology and clinical symptoms and treat both principal and secondary aspects of diseases aiming at the etiology and the diseases.
Owner:TIANJIN SHENGJI GRP CO LTD
Compound echinacea purpurea preparation and preparation method and application thereof
The invention discloses a compound echinacea purpurea preparation. The dose ratio of an echinacea purpurea extract as an effective component to lysozyme is (4-1):1, the dosage of the echinacea purpurea extract and the lysozyme is 20% in total, and the ajudvants contains 64% of saccharose and 16% of dextrin. The echinacea purpurea extract selected by the invention is obtained by extracting echinacea purpurea medicinal material by alkaline ethanol solution and lysozyme for two times, wherein the content of polysaccharide is not less than 21.5%, the content of polyphenol is not less than 8.10% and the content of chicoric acid is not less than 5.00%. The compound preparation provided by the invention has the effects of improving animal immunity, antibiosis and anti-virus, thereby being capable of being taken as the medicine for preventing and treating the animal diseases, in particular to the chicken diseases caused by escherichia coli infections.
Owner:QILU ANIMAL HEALTH PROD +1
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