The invention discloses an
allicin fat emulsion injection and a preparation process thereof; the invention is the
drug which is made by the materials with the following mix ratios by weight, while the pH value of which is 6.5 to 7.5, the average particle size of the
emulsion particles is 200nm, and the particle size thereof is 100 to 300nm and the
Zeta potential is minus 50 to 80mv. The raw materials are:
allicin, egg
yolk lecithin, pluronic F68,
oleic acid, and injection water and so on. The preparation process is that the egg
yolk lecithin,
oleic acid,
vitamin E and
soya bean oil are taken at first under the aseptic conditions for mixing, heating, agitating and dissolving, then the
allicin is added to agitate till
dissolution, and the filtrate can be obtained after the pressure
filtration by a microporous membrane; the
glycerol is taken at first and the injection water, disodium
ethylene diamine tetraacetate and pluronic F68 are added for mixing and agitating till the
dissolution, then the filtrate can be obtained after the pressure
filtration by the microporous membrane; after the mixture of the two filtrates, a high speed
agitator is used for agitating, the product is finally obtained through a
high pressure homogenizer. The invention is characterized by no irritating effect and good stability, etc.