34 results about "Dna double helix" patented technology

The invention discloses a water-soluble perylene bisimide compound and an application of a water-soluble perylene bisimide compound for preparing DNA intercalators, inhibiting cancer cell growth and resisting tumors, belonging to the technical field of biological drug chemical synthesis. A cationic amino functional group is introduced into perylene derivatives and single perylene systems, so that the water solubility is greatly improved, the amino functional group is bound to light stability of perylene derivatives, and a series of novel water-soluble perylene bisimide compounds are obtained. The synthetic compound can be effectively embedded into DNA double helix base pairs of the cell nucleus and can serve as a DNA intercalator. The synthetic compound has a planar rigid structure, can be specifically enriched on a fixed tissue cell nucleus, is high in fluorescence intensity and easy in fluorescence imaging and can be compared favorably with commercial cell nucleus dyes DAPI. The synthetic compound can effectively inhibit growth of cancer cells such as U2OS, HCT116, HeLa and AGS, has an obvious antitumor effect and can be applied to preparing antitumor drugs.

The present invention discloses a nucleotide model device comprising two elongated bodies arranged in a DNA double helix, and further comprising a plurality of groups of connectors, wherein two ends of each connector are respectively connected to the two elongated bodies, a plurality of groups of connectors are sequentially arranged along the axis of the elongated bodies, each connector comprises two connecting posts in butt joint, the connecting posts are configured to have four different appearance marks, each elongated body comprises a plurality of sub-columnar bodies which are detachably connected, the center of each sub-columnar body is provided with a convex member, the convex member is provided with a first connecting portion, and two ends of the connecting post are provided with a second connecting portion and a third connecting portion respectively; the convex member is connected to the sub-columnar body through the detachable connection between the first connecting portion and the second connecting portion, and two sub-columnar bodies form one connector via detachable connection of two third connecting portions. The nucleotide model device provided by the present invention can be used by the learner to connect each element as required in a step-by-step manner into a final double helix model.

The invention relates to a fluorescent high-molecular polymer and a preparation method of the fluorescent high-molecular polymer, in particular relates to a water-soluble cationic polyelectrolyte with an end group provided with fluorophore pyrene, a preparation method of the water-soluble cationic polyelectrolyte, and an application of water-soluble cationic polyelectrolyte in the detection of base sequences of nucleic acid molecules. A novel multi-stranded fluorescent probe is formed by electrostatic adsorption and hydrophobic interaction between the water-soluble cationic polyelectrolyte with the end group provided with fluorophore pyrene and single-stranded oligomerization nucleic acid molecules (DNAs with a hairpin structure and a linear chain structure). When nucleic acid molecules with base sequence structures complementary with those of the fluorescent probe exist, hybridization is performed through Watson-Crick base pairing principle, as the fluorescent pyrene at the end group is inserted into a DNA double-helix structure, the quenching ability of the base to the pyrene fluorescence is enhanced, so that the fluorescence intensity of the pyrene is remarkably reduced compared with that of the pyrene acted on non-target nucleic acid molecules, therefore, the specific identification of the base sequence structures of the nucleic acid molecules can be realized through difference of fluorescence properties of polyelectrolyte with fluorophore pyrene.

The invention relates to a conical interdigital DNA double helix bionic left-handed material, and relates to a left-handed material. The conical interdigital DNA double helix bionic left-handed material is provided with a medium substrate, wherein one surface of the medium substrate is covered with a good conductor layer, an upper pair and a lower pair of crossed symmetric helix metal lines are etched on the good conductor layer, the upper and the lower pairs of crossed symmetric helix metal lines are of a mirror symmetric structure, the upper and the lower pairs of crossed symmetric helix metal lines are connected by virtue of an interdigital metal rod, the inner side of each pair of crossed symmetric helix metal lines is provided with an inward interdigital arm extending beyond an interdigital central line, and the ends of the interdigital arms are leveled to one another. By changing an arc radius of the crossed symmetric helix metal lines and the characteristics of the interdigital structural metal rod, the left-handed characteristics of the left-handed material is flexibly controlled. The conical interdigital DNA double helix bionic left-handed material is simple in structure and convenient to process; by virtue of high coupling performance of the crossed symmetric helix metal lines and the interdigital metal rod, in the case of small transmission loss and small unit electrical length, the double negative frequency band and the negative index frequency band are relatively wide, and the application field of the left-handed material is enlarged.

The invention belongs to the field of a DNA nanotechnology, and relates to a design method of a light-activated logic circuit based on a DNA double-helix structure. The application of realizing a biological logic function through partial optical signal transmission is the hot application of a DNA molecule logic circuit. According to the method, the DNA double-helix structure is taken as a bracket platform; a mode of encoding position information of fluorescence molecules by use of two layers of DNA strand displacement reaction is designed; and compared with a single-layer DNA strand displacement encoding mode, the mode provided by the invention has the advantages that under the condition that the numbers of fluorescence molecules are the same, the input signals is doubled. Moreover, through adoption of a fluorescence resonance energy transfer technology, the multifunctional light-activated logic circuit with multi-way input is realized.