37 results about "Double negative" patented technology

A pulse excitation bistable electromagnetic actuator is used in fields such as relays, contactors, circuit breakers, solenoid valves, and electromagnets. Using pulse current excitation to actuate, magnets or retaining rings, spring pins, springs, etc. maintain a steady state, eliminating the need for prior art - positive and negative bi-directional pulse generation circuits and winding changeover switches in magnetic holding bistable; or in mechanical bistable Complicated bistable mechanism and return force spring can switch between two stable states only by inputting one-way pulse successively with one switch. It has the advantages of energy saving, anti-vibration, simple structure, easy miniaturization, not easy to shake, and long working stroke. features. It consists of a machine base, an electromagnet containing moving parts and a device for maintaining the steady state of the moving parts. It can be freed from the constraints of the steady-state maintaining device by the pulsed force of the electromagnet, swing from one side to the other side by relying on inertia to cross the point of maximum magnetic attraction, and be in a stable state again under the action of the steady-state maintaining device.

The inventors demonstrate that treatment of young, suckling mice with a glycolipid derived from Helicobacter pylori activates NKT cells in a CD1d-restricted fashion, and is protective against AHR in a model of allergen-induced asthma. The inventors further found that this protective effect can be transferred by NKT cells exposed to the glycolipid, and is associated with the expansion of a suppressive double-negative NKT cells and Foxp3+ TReg cells. The inventors also demonstrate herein that pretreatment of adult mice with a glycolipid derived from Helicobacter pylori partially suppresses airway hyperreactivity and inhibits BAL inflammation in an ozone-exposure model. Accordingly, provided herein are compositions and methods for the treatment and prevention of inflammatory diseases, such as asthma or autoimmune diseases, in a subject in need thereof.

A method of expanding double negative T cells in culture is described. The method comprises (a) providing a starting sample comprising DN T cells or precursors thereof; (b) substantially depleting CD8+ and CD4+ T cells from the starting sample; (c) culturing the sample from step (b) with an immobilized T cell mitogen in a culture medium comprising an agent that can stimulate DN T cell growth; (d) washing the cells obtained in step (c) and resuspending in a culture medium comprising the agent without the T cell mitogen; and (e) washing the cells obtained in step (d) and resuspending in a culture medium comprising the agent and a soluble T cell mitogen. The DN T cells obtained by the method are useful in a variety of applications including the treatment of cancer, infectious diseases, graft versus host disease and autoimmune disease.

The invention discloses a double-negative pressure sputum aspiration device, comprising a sputum aspiration pipeline (1), a transitional connection component (2), a sputum storage bag (3), a shell (4) and a negative pressure channel (5), wherein the sputum storage bag (3) is connected with the negative pressure channel (5) through the transitional connection component (2) and the sputum aspiration pipeline (1), the sputum storage bag (3) is arranged inside the shell (4), and a gap (4-1) from the sputum storage bag (3) to the inner wall of the shell (4) is connected with the shell (4). In the device, based on the principle of double negative pressures, the soft and small sputum storage bag (3) is arranged inside the shell (4) to replace a hard and large sputum storage bottle (8), thereby overcoming the defects of traditional sputum aspiration device.

The invention discloses a two-way negative pressure forming needle bed, which comprises: a cabinet assembly and a power supply assembly; the cabinet assembly is formed by stacking a plurality of storey layers, and the storey layer includes: a bottom plate assembly; an upper plate arranged above the bottom plate assembly Components; the middle plate component that is movably arranged between the bottom plate component and the upper plate component; the negative pressure component that is set on the upper plate component and used to form the battery; the negative pressure component is set as a double negative pressure component, and includes: negative pressure The cup module and the negative pressure manifold connected with the negative pressure cup module; the negative pressure cup module, the negative pressure manifold and the preset negative pressure control system form a double negative pressure loop. The invention adopts double negative pressure circuits to form the battery, and forms a uniform, stable and dense SEI film on the negative electrode of the lithium ion battery under the negative pressure environment, so that the performance of the battery is more stable and the quality of the battery is improved.

The invention discloses a hydrogen-nickel battery negative electrode sheet and a method for manufacturing a hydrogen-nickel battery using the same. The negative electrode sheet is a double negative electrode sheet, and the manufacturing method comprises welding a single negative electrode short sheet at the end of a single negative electrode long sheet through a negative electrode connection substrate. Double negative electrode sheet, first weld a small piece of protective film with a width larger than the width of the negative electrode connection substrate on the diaphragm corresponding to the connection seam of the double negative electrode sheet, and then place the diaphragm welded with the protective film between the positive and negative electrode sheets, and then place the The double negative plate, diaphragm, and positive plate are rolled into a cylindrical shape and loaded into the battery case, and finally the nickel-hydrogen battery is assembled by injecting electrolyte, installing a cap and sealing ring. It can effectively control and manufacture pole pieces with different thicknesses and different amounts of negative electrode active materials, improve the utilization rate of negative electrode active materials and the performance of the battery, correspondingly reduce the thickness of double negative electrode pieces and occupy the volume of the shell, and reduce the battery life. The manufacturing cost and assembly difficulty significantly improve the manufacturing efficiency of the battery, and are especially beneficial to the manufacture of high-capacity batteries.

The invention discloses a tetracyclic compound capable of promoting in-vitro proliferation of double-negative T cells. The tetracyclic compound is IMC-00239, and the molecular formula of the tetracyclic compound is shown in the description. The invention relates to the tetracyclic compound which can be used for promoting in-vitro proliferation of the CD3<+> / CD4<-> / CD8<->double-negative T (DN T) cells and is selected from a compound library according to a high-throughput screening method, and provides a pharmaceutically acceptable salt and a prodrug of the tetracyclic compound. The compound is a restrainer of a Wnt signal channel, and can induce degradation of beta-Catenin of the DN T cells, shorten cell cycle and promote karyokinesis when being used in in-vitro experiments. The compound can effectively promote the construction of a CAR-DN-T in-vitro proliferation system, and help implementation of a CAR-DN-T cell factory.

The invention relates to a bi-directional constant current source device based on dual negative feedback control, and belongs to the technical field of electronic technique. The bi-directional constant current source device structurally comprises a front panel (10), a current setting module (1), an output control module (5), a power output module (6) and a first feedback module (7), and is characterized by further structurally comprising a subtracter module (2), a PID module (3), a limited current setting module (4), a second feedback module (8) and a display driver module (9). The bi-directional constant current source device adopts the dual negative feedback structure, thereby having the characteristics of being high in output current stability, high in safety, wide in range of usage occasions and the like, the limited current setting function is achieved, and output current dual-directional regulation can be further realized.

Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.

The invention relates to disposable sanitary production line equipment, in particular to an adhesive tape cutter device with inserts interchangeable. Two groups of negative pressure holes are formed in a bottom roller and are symmetrical relative to the bottom roller, a locating face is formed on the part, between the two groups of negative pressure holes, of the bottom roller, a group of protruding locating pillars are arranged on the locating face, the negative pressure holes are communicated with a negative pressure plate, a negative pressure box is provided with two negative pressure openings, the negative pressure openings are connected with the negative pressure plate through negative pressure pipes, and a cutter system and a cam bonding system correspond to one group of negative pressure holes respectively. According to the structure of the adhesive tape cutter device, the bottom roller is provided with double negative-pressure suction structures, the locating pillars are arranged between the two groups of negative pressure holes, in the material conveying process, even if the negative pressure holes are not covered, materials cannot be subjected to sliding or displacement on the bottom roller under the action of the locating pillars, the areas of the negative pressure holes are decreased, and power of a vortex air pump can be reduced.