88 results about "Design synthesis" patented technology

An integrated circuit design library includes a timing parameter representative of a design element in an integrated circuit; an area size parameter representative of the design element in an integrated circuit; and a routing demand parameter representative of a number of connections required for the design element for each value of the timing parameter and the area size parameter.

The present invention pertains to automated technology dependent transformations for Silicon-On-Insulator (SOI) in the digital design synthesis, the transformations include the steps of receiving input design specification in the form of technology independent specification or interconnected library of standard-cells; performing the technology dependent transformations in the digital design synthesis, resulting in interconnected SOI standard-cells from a SOI target library accounting for floating body effects, including floating body effects affecting delays over long periods of simulation time or testing over long times on fabricated SOI library cells, or SOI transistor level representations, transistor sizing and evaluating the standard-cell mapping and transistor-level representation for all or portion of the input design specification iteratively to meet delay and power constraints for SOI.

The invention discloses a method for preparing ziconotide. The technical scheme of the invention comprises the following steps: (1) obtaining an Fmoc-Cys(Acm)-amino resin from Fmoc-Cys(Acm)-OH and an amino resin; (2) obtaining a linear-ziconotide-amino resin of which a Cys side chain comprises Acm by performing the solid phase synthesis on the Fmoc-Cys(Acm)-amino resin and an amino acid adopting Fmoc group protection; (3) obtaining a linear crude peptide of which the Cys side chain comprises the Acm by performing cracking on the linear-ziconotide-amino resin of which the Cys side chain comprises the Acm, and obtaining linear ziconotide by removing the Acm, purifying and freeze-drying; (4) and obtaining the ziconotide by performing cyclization, purifying and freeze-drying on the linear ziconotide. The method for preparing ziconotide has the characteristics of simple reaction operation, easy subsequent treatment, low raw material investment, low cost, high yield and the like, and has considerable economic and practical value, and also has wide application prospect in the field of design synthesis of polypeptide drugs.

The invention relates to a preparation method and an application for nitrogen phosphorus co-doped porous carbon. A precursor copolymer is self-assembled through a one-step method; and high-temperature roasting is performed to prepare the nitrogen phosphorus co-doped porous carbon. A prepared catalyst material is obvious in porous structure and large in specific surface area; and more catalytic active sites are exposed, so that the electro-catalysis oxygen reduction activity can be improved. The preparation method for performing precursor copolymerization by using simple weak interaction to further synthesize a material with a certain morphology is simple in step and easy in operation; and a synthesis mechanism of the preparation method has an important enlightening effect for large-scale design synthesis of a nanometer material in the future and application of the material to the research of the fields of electro-catalysis, supercapacitors, adsorption separation and the like.

The invention discloses design synthesis and application performance of a novel D-A-D organic near-infrared tumor therapy reagent based on diketopyrrolopyrrole. The reagent provided by the invention is mainly obtained by Suzuki coupling reaction of 3, 6-bis(thieno[3, 2-c]thiophene)-2, 5-dihydropyrrolo[3, 4-c]pyrrole-1, 4-dione derivative and phenothiazine borate. By means of a reprecipitation method, the reagent can acquire a nano material with absorption wavelength in a near-infrared area, the nano material has high singlet oxygen yield, good photothermal conversion efficiency, excellent water dispersibility and tumor tissue targeting properties, can be applied to tumor cell and living body treatment, can effectively inhibit tumor cell migration while effectively killing tumor cells, thereby achieving the photothermal and photodynamic synergistic treatment effect. Therefore, the reagent can have enormous application prospects in tumor therapy.

The present invention pertains to automated technology dependent transformations for CMOS digital design synthesis resulting in a combination of CMOS interconnected standard-cells from a target CMOS library being mapped and transistor-level representation for all or portion of the input design specification, the transistor level type and portion or portions to be represented at the transistor level representation being chosen by a user, transistor sizing and evaluating the combination of said transistor-level representation and standard-cell mapping iteratively to meet delay, size and power constraints for CMOS.

Methods and apparatuses to automatically determine conditions at hierarchical boundaries of a hierarchical circuit design and to use the determined conditions in hierarchical optimization and verification. In one embodiment, a hierarchical block is optimized and transformed during design synthesis using one or more lemmas at the boundary of the hierarchical block. For example, the lemmas are automatically generated to specify range information for input boundary nodes. The lemmas are also used for the equivalence checker to perform hierarchical equivalence checking. Equivalence of hierarchical blocks is individually checked, in view of the lemmas. Thus, based on the lemmas, optimizations across hierarchical boundaries can be performed, while the hierarchical structure of the design is preserved so that equivalence checking of hierarchical circuit designs can still be based on the equivalence of individual hierarchical blocks.

A method for the design synthesis of an exponential current digital-to-analog (IDAC) using a binary-weighted MSB. The design synthesis involves defining an exponential LSB and exponential MSB current mirrors according to a defined methodology. A method to achieve an exponential current digital-to-analog converter (IDAC) having improved accuracy using a binary-weighted most significant bit (MSB) comprising (1) defining a differential non-linearity (DNL); (2) defining number of LSB bits needed for the targeted DNL with a binary weighted MSB; (3) calculating the number of bits to be used for the binary-weighted MSB to get the desired IDAC base; (4) deriving the minimum current for the Imax; (5) defining the LSB as an exponential current mirror according to the specified relationship for the ILSB; and (6) defining a binary-weighted MSB according to the specified relationship for IMSB.

The invention discloses a symmetric benzimidazole ruthenium complex and its preparation method and belongs to the technical field of synthetic chemistry. According to the preparation method, 2,4,6-trismesitylene and triethyl phosphate are used as starting materials, a fixed ligand is synthesized by a two-step method, and the fixed ligand finally reacts with ruthenium trihydrate under the microwave condition so as to synthesize the target product. The synthesized symmetric benzimidazole ruthenium complex has excellent stability and optical and electrochemical properties. Through covalent bond effect between symmetric phosphate groups at two ends of the molecule and the surface of a conductive substrate such as ITO and the like, the symmetric benzimidazole ruthenium complex molecule is fixed to the conductive substrate and layer-by-layer self-assembly is realized. The symmetric benzimidazole ruthenium complex is an excellent photosensitizer. In addition, the designed synthesis process of the symmetric benzimidazole ruthenium complex is simple, costs are low, and the microwave-assisted synthesis technology is rapid and efficient.

A method (100) for cascading system level target to component level design objectives using machine learning and design synthesis techniques. The method (100) of the present invention uses machine learning techniques to build (106, 108) surrogate models from given system targets (102). The method then employs design synthesis methods to determine (110) a range of component level design objectives for the given system level targets using the surrogate models. The range of component level design objectives is fed back (112) to one of the surrogate models to determine (114) the component design objectives.

The invention provides an aircraft nose wheel steering control box design method based on a graphical model. The model-based design method adopts a model to describe a system. The method performs simulation and analysis of system theories and functions before product manufacturing through three steps of demand analysis, function analysis and design integration, and thus system features are fully and precisely mastered, thereby reducing development iteration frequency, reducing cost, shortening period, improving design quality and improving development frequency.

Methods and apparatuses to automatically determine conditions at hierarchical boundaries of a hierarchical circuit design and to use the determined conditions in hierarchical optimization and verification. In one embodiment, a hierarchical block is optimized and transformed during design synthesis using one or more lemmas at the boundary of the hierarchical block. For example, the lemmas are automatically generated to specify range information for input boundary nodes. The lemmas are also used for the equivalence checker to perform hierarchical equivalence checking. Equivalence of hierarchical blocks is individually checked, in view of the lemmas. Thus, based on the lemmas, optimizations across hierarchical boundaries can be performed, while the hierarchical structure of the design is preserved so that equivalence checking of hierarchical circuit designs can still be based on the equivalence of individual hierarchical blocks.

An integrated circuit design library includes a timing parameter representative of a design element in an integrated circuit; an area size parameter representative of the design element in an integrated circuit; and a routing demand parameter representative of a number of connections required for the design element for each value of the timing parameter and the area size parameter.

A task-based multi-process design synthesis methodology relies on a plurality of child processes to assist a parent process in performing optimizations on an integrated circuit design. Objects from an integrated circuit design are grouped into subsets and assigned to child processes, with each child process performing a transform on each of the objects in the subset assigned to that child process and determining which of the objects in the subset are candidate objects for which performance of the transform has been successful. Each child process also provides result data to the parent process for each candidate object to reduce the overhead of the parent process when performing the transform on the candidate object. The result data, which may include, for example, a set of instructions or hints, may allow a parent process to take advantage of the efforts of the child process in performing the transform.

The invention provides xanthone fluorochrome and application therefore to design synthesis of a fluorescence probe. The Xanthone fluorochrome has the following structure general formulas I, II, III and IV shown in the description, wherein R1, R2, R3 and R4 are respectively selected from hydrogen, halogen, hydroxyl, NH2, sulfydryl, cyano-group, nitryl, N,N-bis-C1-4 alkyl amino group, aldehyde group, carboxyl, amido, sulfoamido, C5-10 aryl, C2-8 heterocyclic aryl, C1-6 alkyl, boric acid, boronic acid pinacol ester and OR (wherein R is C1-4 saturated alkyls or unsaturated alkyls).

The invention belongs to the technical field of synthesis of organic-inorganic hybrid materials and relates to an electron transfer type hybrid photochromic material and a preparation method thereof.The method comprises the following steps: uniformly mixing oxalic acid, a metal source, TPT, a phosphorus source and DMF or DMAc to obtain a mixture, loading the mixture to a stainless steel high-pressure reaction container provided with a polytetrafluoroethylene reactor and crystallizing the mixture at 145 DEG C for 7-8 days to obtain blocky colorless or grey violet crystals with good crystallinity; performing deionized water washing and suction filtration on the crystals sequentially, and performing drying at room temperature to obtain the electron transfer type hybrid photochromic material.The prepared material is novel in structure, the preparation process is simple and convenient to operate, and reference is provided for design synthesis and application research of the electron transfer type hybrid photochromic material.

The present invented method includes determining design synthesis coefficient Ak, determining steam turbine noumenal availability AP 1, determining steam turbine autocontrol subsystem availability AP 2, determining steam turbine oil servicing and lubricating oil subsystem availability AP 3, determining steam turbine heat engineering monitor and protected subsystem availability AP 4, determining steam turbine vapour lock and dewatering subsystem availability AP 5, determining steam turbine scheduled outage coefficient POF, calculating steam turbine availability coefficient AF, finally evaluating result, only scheme turnaround year steam turbine availability coefficient AF >= 0.92 and steam turbine designed usability reaching fineness value, otherwise to proceed improved design until turnaround year steam turbine availability coefficient availability coefficient AF >= 0.92 and reaching fineness value. Said invention has advantages of in design stage capable of quantitative calculating, quantitative evaluation and effectively raising steam turbine availability coefficient.

The present invention relates to a graphical user interface for a system that complies MATLAB models for synthesis into register transfer level code. The graphical user interface provides a visual representation of the design in a manner that allows the user to more easily understand the algorithm being modeled. From this interface, the user may also modify the type, size and dimensions of variables from dialog boxes. The system allows the user to efficiently compare and verify a fixed-point design versus the MATLAB design. The interface allows the user to then make further changes to the design, or synthesize the design into a register transfer level file.

A method and system for tiling a bias design for an integrated circuit device to facilitate efficient design rule checking. The method is implemented in a computer implemented design synthesis system. The method includes receiving a circuit netlist, wherein the circuit netlist represents an integrated circuit design to be realized in physical form. A deep N-well bias voltage distribution structure is provided within the circuit netlist, wherein the structure includes a plurality of tiles arranged to distribute a bias voltage to a plurality of N-wells of the circuit netlist.

The invention discloses an in-vitro screening method for antineoplastic activity of artemisinin and derivatives of the artemisinin. The method comprises the following steps: analyzing the interaction between the artemisinin or the derivatives of the artemisinin and transferrin by adopting ultraviolet-visible absorption spectra or fluorescence spectra; calculating the combining factor Kb of the artemisinin or the derivatives of the artemisinin and the transferring; comparing the combining factor Kb of the artemisinin or the derivatives of the artemisinin and the transferring, or sequencing according to the combining factor Kb, and inferring the strength sequence of the antineoplastic activity of the artemisinin or the derivatives of the artemisinin; and verifying screening results by adopting antineoplastic activity tests. According to the method, a spectroscopic method is used for detecting the combining factor Kb of the artemisinin or the derivatives of the artemisinin and the transferring, and the in-vitro screening is carried out on the antineoplastic activity of the artemisinin and the derivatives of the artemisinin according to the sequence of the combining factor Kb. By using the method, the antineoplastic activity of the derivatives of the artemisinin can be fast and effectively judged, the method can be used for providing the base for designed synthesis of artemisinin-based drugs and clinical application of the artemisinin-based drugs, and promoting the application of the artemisinin-based drugs in the antineoplastic field.

The invention relates to an inverse linear quadratic control method of a hot continuous rolling thickness-loop synthetic system. According to dynamic models of a loop control system and a automatic gauge control system, a continuous state space model of the hot continuous rolling thickness-loop synthetic system is established by using a state space analysis method; based on the established continuous state space model, proper sampling periods are selected, a zero-order holder method is adopted, the obtained continuous model is subjected to discretization, and a discrete state space model of the hot continuous rolling thickness-loop synthetic system is obtained; and on this basis, the inverse linear quadratic controller (ILQ) of the synthetic system is designed. According to the inverse linear quadratic control method of the hot continuous rolling thickness-loop synthetic system, in an existing hot continuous rolling control system, the automatic gauge control (AGC) system and the loopcontrol system are regarded as two independent control systems, and the problem of multivariable coupling between systems cannot be processed is solved; and according to the technical scheme providedby the embodiment of the inverse linear quadratic control method of the hot continuous rolling thickness-loop synthetic system, the coordinated optimization control of the thickness, tension and anglein the hot continuous rolling control system can be realized.

A method is provided to incorporate information currently known about an integrated circuit's design, including peripheral components that share the same printed circuit board (PCB) with the integrated circuit, to automate a clock signal instantiation and routing solution to realize a comprehensive design. The information derived from a hardware design synthesis tool includes the existence of PCB resources, such as fixed-frequency oscillators, that may co-exist with a particular integrated circuit, such as a programmable logic device (PLD). Other derived information includes details concerning clock modules and cores that may exist within the PLD in accordance with the PLD's design specification. Once the information that describes the PLD and its environment is known, the information is utilized to automatically instantiate resource interconnect cores and automatically generate connections between the fixed-frequency oscillators, resource interconnect cores, and PLD implemented cores that are contained within the design.

The invention relates to a symmetrical binuclear ruthenium complex and a preparation method utilizing microwave, belonging to the technical field of synthetic chemistry. The preparation method comprises the following steps: firstly reacting 2-acetylpyridine with 4-bromobenzaldehye as a starting raw material, wherein traditional NaOH and CH3OH are respectively replaced with KOH and EtOH to further shorten reaction time; performing cross-coupling reaction to the obtained terpyridyl compound and diethyl phosphite, wherein the P-H bond in diethyl phosphite is cut off by taking triethylamine as a salt base; then synthesizing an intermediate complex together with ruthenium trichloride hydrate RuCl3.3H2O, and then synthesizing a target product under microwave conditions. The complex molecules can be adsorbed onto a conductive substrate such as an ITO and the like by taking phosphoryl groups at two ends of the complex molecules as fixed ligands and layer-by-layer self assembling can be realized, and the symmetrical binuclear ruthenium complex is an excellent photosensitive dye. The symmetrical binuclear ruthenium complex is simple in design synthesis process and low in cost, and the microwave-assisted synthesis technology is fast and efficient.

The invention discloses an asymmetric synthesis method of a gamma-alkenyl substituted butenolide or butenolactam compound. The method adopts cheap nickel to catalyze a [3+2] asymmetric cycloaddition reaction of a cyclopropenone compound and alpha, beta-unsaturated ketone or imine, the selective insertion reaction of intermolecular C=X after nickel-catalyzed C-C bond activation is realized for thefirst time, wherein X is equal to O or N, the gamma-alkenyl substituted butenolide or butenolactam compound is obtained in a high yield, high enantioselectivity and chirality controllable manner, thesynthesis method is novel, condition mildness, substrate with good applicability, simple and efficient reaction, cheap and readily available catalyst, according to the present invention, the synthesisprocess is simple, the atom economy is good, the synthesis product is easy to derivatize, the method can be widely used in completely-synthesized designed synthesis building blocks and new chiral drug derivatives, and the ligand compound is further provided, and can be used for the asymmetric synthesis of gamma-alkenyl substituted butenolide or butenolactam compounds.

The invention discloses a method for designing and synthesizing anti-PCV shRNA. The method comprises the steps of: 1) selecting a section of nucleotide sequence with length of 19bp according to genomesequence of PCV-2 and by taking Rep gene or Cap gene as target gene; 2) selecting a nucleotide sequence as a candidate nucleotide sequence, which meets the following three conditions: GC content of the nucleotide sequence is between 40 percent and 60 percent; at least three A or T nucleic-acid residues exist among locus from 15 to 10; and secondary structure is ensured not to be generated by 19bpnucleotide sequence after inspection; and 3) comparing the obtained candidate nucleotide sequence with PCV genome so as to determine whether the candidate nucleotide sequence only specially aims at the target gene. The anti-PCV shRNA provided by the invention can play the anti-virus role by restricting reproduction of PCV in cells.

The invention provides a human interleukin29 mature peptide mutant (hIL-29Z) with arginine and lysine produced respectively by site-directed mutagenesis of 33th lysine and 35th arginine and a preparation method thereof. The preparation method comprises the following steps of 1, carrying out artificial design synthesis of a site-directed mutagenesis primer, 2, carrying out site-directed mutagenesis of 98th and 104th basic groups of a hIL-29 mature peptide encoding gene by the site-directed mutagenesis primer, 3, constructing a recombinant eukaryotic expression vector containing a hIL-29 mutant encoding gene, and carrying out pichia pastoris transformation to obtain recombinant engineered yeast, 4, carrying out culture of the recombinant engineered yeast, and adding 1.5% (v / v) of methanol into the culture solution so that hIL-29 mutant expression is induced, and 5, through SP-Sepharose Fast Flow cation-exchange chromatography, carrying out purification of the hIL-29 mutant in the supernatant of the culture solution. The engineered yeast obtained by the invention can be subjected to high-density culture, can secrete and express the hIL-29Z with arginine and lysine produced respectively by site-directed mutagenesis of 33th lysine and 35th arginine, and is suitable for industrial preparation of hIL-29 mature peptide mutants.

The invention discloses an image synthesis method and device, equipment and an image carrier. The method comprises the following steps of: obtaining image data and forming a printable area; calling asynthesis material according to a user operation and obtaining configuration information of the synthesis material; and synthesizing the synthesis material to the printable area according to the configuration information so as to generate image synthesis data. According to the method, more convenient image edition environment is provided for users, so that memory occupation of terminal equipment is saved, synthesis effect pictures of image data and synthesis materials are drawn, and the designed synthesis effect pictures can be browsed in real time.

The invention describes a semi-automated method and system for Field Programmable Gate Array (FPGA) timing closure. The method is used to achieve timing closure by storing all previous results of design synthesis, place & route, tool options, and area constraints in a database, applying a set of analysis algorithms on the entire build history, and applying a decision engine to determine set of synthesis and place & route tool options and area constraints for the next build iteration. The aim of the inventive method is to eliminate most of the manual steps during design timing closure. The inventive method further makes the process faster, requiring fewer build iterations, and more robust to small design changes that can affect timing results. The desired outcome is achieved by making decisions based on the analysis of all the previous build results.