The invention provides a composite antisludging agent of a reverse osmosis / nanofiltration system. The composite antisludging agent comprises the following components in percentage by weight: 2%-10% of cyclodextrin solution, namely a component I, 80%-90% of at least one or a mixture of amino trimethylene phosphonic acid (ATMP), a copolymer of maleic anhydride-acrylic acid (MA-AA), 2-phosphonic acid butane-1, 2,4-tricarboxylic acid (PBTCA), and hydroxyl ethylidene diphosphonic acid (HEDP), namely a component II, and 1%-10% of 2,2-dibromo-2-cyano-acetamid (DBNPA), namely a component III. The composite antisludging agent is prepared by mixing the component II and the component III, and then fusing the obtained mixture with the component I. When being applied to the reverse osmosis / nanofiltration / ultrafiltration system, the composite antisludging agent can be used for effectively relieving the pollution to the reverse osmosis / nanofiltration / ultrafiltration system caused by polcard, calcium sulphate salt, barium sulfate, strontium sulfate, calcium fluoride, colloidal iron and colloidal silica, relieving biological contamination simultaneously, improving the working efficiency of the system, prolonging the cleaning period and the service life of the reverse osmosis / nanofiltration / ultrafiltration system, and reducing the cost of reverse osmosis.