36 results about "Cardiovascular implant" patented technology

The present invention provides compositions including a cell contacting surface or film comprising nanotopography of nanofibers, nanotubes, nanochannels, microchannels or microwells, which are capable of enhancing or promoting cell differentiation or cell viability. The compositions are useful as medical implants, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants. The present invention also provides methods of treating a patient in need of such an implant.

Methods, devices and systems facilitate retention of a variety of therapeutic devices. Devices generally include an anchoring element, which has been designed to promote fibrotic ingrowth, and an anchored device, which has been designed to firmly engage the complementary region of the anchoring element. The anchoring element may be placed in a minimally invasive procedure temporally separated from the deployment of the anchored device. Once enough time has passed to ensure appropriate fixation of the anchoring element by tissue and cellular ingrowth at the site of placement, the anchored device may then be deployed during which it firmly engages the complementary region of the anchoring element. In this manner, a firm attachment to the implantation site may be made with a minimum of required hardware. Some embodiments are delivered through a delivery tube or catheter and while some embodiments may require laparoscopy or open surgery for one or more of the placement procedures. Some embodiments anchor devices within the cardiovascular tree while others may anchor devices within the gastrointestinal, peritoneal, pleural, pulmonary, urogynecologic, nasopharyngeal or dermatologic regions of the body. An alternative embodiment provides for the placement of the anchoring element and anchored device simultaneously, but allows for their removal separately. This embodiment allows the device, which may be placed only temporarily and be designed to be removed, to experience significant fibrotic ingrowth, but then to be easily detached from the ingrowth-anchored region to allow for simple and quick device removal.

The invention provides a method and a system for automatically detecting and evaluating cardiovascular implanted stents on the basis of OCT (optical coherence tomography). The method includes steps of acquiring to-be-detected coronary artery OCT images; preprocessing the to-be-detected coronary artery OCT images; carrying out sliding window traversal on preprocessed images; extracting characteristics of sliding window images; judging whether extracted characteristic values of the sliding window images are higher than characteristic thresholds corresponding to classifier models or not; detecting regions where stents in the sliding window images are located and the centers of the stents; detecting contours of the inner walls of coronary arteries in the preprocessed images; computing the shortest distances from the centers of the stents to the contours of the inner walls of the coronary arteries to obtain wall attaching conditions or covering conditions of the stents; displaying the wall attaching conditions or covering conditions of the stents. The method and the system have the advantages that the system can work in complicated imaging environments without being affected by noise such as blood artifact, and the method and the system are high in stent detection accuracy and good in robustness.

The invention discloses an artificial polymer aorta valve, belongs to the technical field of medical instruments, and particularly belongs to angiocarpy implantation materials. The artificial polymer aorta valve comprises three valve leaflets and a valve ring. The valve leaflets are fixed to the valve ring, and the valve ring is sutured to the human aortic root in a valve replacement operation. The valve leaflets have the function of controlling blood to move in one direction under the drive of differential pressure. According to the diameter of the aorta valve ring of a patient, the artificial polymer aorta valve of the proper size is selected. The artificial polymer aorta valve has the advantages that the artificial polymer aorta valve is suitable for replacing the human aorta valve; stress borne by the free edges of the valve leaflets, the coaptation area, the connecting positions of the valve leaflets and the aortic root and the middles of the valve leaflets is increased in sequence; the middles of the valve leaflets are thinnest and bear the largest deformation, and therefore the performance of the materials can be achieved fully; the service life of the valve is prolonged in the high circulating bending force bearing environment; the artificial valve is designed according to the anatomical structure of the human aorta valve, and the blood flows through the valve in the excellent hemodynamic environment.

The invention discloses a method for forming an albumen layer by mediating albumin on the surface of a material, a biological material and application thereof and relates to the technical field of biomaterials. The method for forming an albumen layer by mediating albumin on the surface of a material includes standing a to-be-supported material in an alkaline solution and then obtaining an alkali-activated material; fixing dendrimers on the surface of the alkali-activated material, and then immersing the modified material in an albumin solution for standing reaction. Preferably, the dendrimer is a polyamide-amine dendrimer PAMAM; and more preferably, the molecular weight of PAMAM is 6000 to 10000. The biological material forms a PAMAM layer and the albumin layer on the surface of the to-be-supported material, and the albumin is mediated to form the albumen layer. The biological material is used for preparing a cardiovascular implant material and can reduce the adhesion of platelets to achieve anticoagulation, and the biocompatibility of the material is improved.

The invention discloses a nickel-titanium alloy containing a biologically-active coating. A preparation method for the alloy comprises the following steps: polishing the surface of the nickel-titanium alloy so as to allow the surface of the nickel-titanium alloy to be shining; then soaking the alloy in a Tris-dopamine hydrochloride solution with a concentration of 1 to 3 mg/mL for 12 to 36 h so as to allow a polydopamine film to be formed on the surface; preparing a chitosan solution with a concentration of 1 to 10 mg/mL with 0.1 to 0.5% (v/v) acetic acid as a solvent, preparing a gelatin solution with a concentration of 1 to 10 mg/mL and an endothelial cell growth factor solution with a concentration of 100 to 500 ng/mL by using a phosphate buffer solution, soaking the treated nickel-titanium alloy in the gelatin solution for 12 to 36 h and then carrying out self-assembling of chitosan-gelatin-endothelial cell growth factor-gelatin layer by layer, wherein soaking in each solution lasts for 5 to 20 min and there are 4 to 10 cycles of layer-by-layer self-assembling; and finally, carrying out blow-drying with nitrogen. The coating can effectively promote adhesion and growth of endothelial cells on the surface of the nickel-titanium alloy, so demands of rapid endothelialization of the nickel-titanium alloy as a cardiovascular implant material are met, the problems of induction of thrombi and generation of coagulation on the surface of the nickel-titanium alloy are overcome, and the clinical application scope of the nickel-titanium alloy is broadened.

The invention discloses a cardiovascular implant intervention material/instrument biological film coating and a preparation method thereof. The preparation method comprises the following steps: (1) preparing a cell membrane vesicle suspension; (2) constructing a super-hydrophilic coating on the surface of the substrate material; and (3) co-incubating the cell membrane vesicle suspension obtained in the step (1) and the super-hydrophilic coating obtained in the step (2), and cleaning with deionized water to obtain the cardiovascular implant intervention material/instrument biological membrane coating. The invention also comprises the cardiovascular implant intervention material/instrument biological film coating prepared by the method. According to the coating, the surface of a large-scale medical device is coated with a cell membrane for the first time, the anticoagulation performance and the anti-inflammatory performance of a blood contact material can be effectively enhanced, and the coating has the capacity of promoting endothelial repair and can be suitable for modification of medical interventional devices such as heart occluders, heart valves, intravascular stents and artificial blood vessels; the inflammatory reaction degree and the thrombosis risk after the instrument is implanted can be obviously reduced.

The invention discloses a cardiovascular implant based on in-situ regulation and control of immune response and a preparation method thereof, and belongs to the technical field of biological medicine, and the technical scheme is characterized in that the cardiovascular implant comprises a cardiovascular implant body and H4000-CD25/dcas9 slow-release nanoparticles modified on the cardiovascular implant body; the H4000-CD25/dcas9 sustained-release nano particle comprises an H4000 plasmid nano carrier (Engreen), a CD25 antibody and a dcas9 plasmid sequence, and is characterized in that the H4000-CD25/dcas9 sustained-release nano particle comprises a H4000 plasmid nano carrier (Engreen), the preparation method of the cardiovascular implant comprises the following steps: constructing the cardiovascular implant body, preparing the H4000-CD25 nano transfection carrier, preparing the H4000-CD25/dcas9 sustained-release nano-particles, and coupling the H4000-CD25/dcas9 sustained-release nano-particles to the cardiovascular implant body. The method is mainly used for constructing the cardiovascular implant modified with the H4000-CD25/dcas9 sustained-release nanoparticles, nerve fibers can be induced to grow into engineering blood vessels, and the anti-thrombus function of the cardiovascular implant is improved and in-situ regeneration of the cardiovascular implant is promoted by utilizing the regulation and control capability of Treg cells on immune response.

A delivery catheter for implanting a self-expanding implant such as a cardiovascular implant. An outer catheter shaft is formed as an implant capsule for encasing the implant during delivery. A flexible distal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is attached, directly proximally of the implant, in a fixed position to a first, inner catheter shaft, and/or a flexible proximal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is inserted at the proximal end of the implant capsule into the second, outer catheter shaft in a fixed position.

The invention relates to the technical field of cardiovascular implant implantation, in particular to a connecting piece and an assembling process of a cardiovascular implant and conveying equipment, the connecting piece is used for connecting the cardiovascular implant and the conveying equipment, the connecting piece comprises a main body, a connecting hole and a threaded hole are formed in the main body, the connecting hole is used for inserting a mounting part of the cardiovascular implant, and the threaded hole is used for being in threaded connection with the conveying equipment. When the connecting piece is used for connecting the cardiovascular implant and the conveying equipment, a connecting end or a closing-up structure is reduced, the risk of generating micro thrombus can be effectively reduced, stress on each part of the implant is uniform, the structure is simple, welding spots are reduced, in addition, the foreign matter content and the surface area are also reduced, and the risk of corrosion is further reduced.